ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex. [PDF]
PLoS ONE, 2013 The radial migration of neuronal progenitor cells is critical for the development of cerebral cortex layers. They go through a critical step transforming from multipolar to bipolar before outward migration.
Qingyu Li +7 more
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VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy- Terminal NRP1 Fragments That Regulate Angiogenic Signaling [PDF]
, 2018 OBJECTIVE: NRP1(neuropilin-1) acts as a coreceptor for VEGF (vascular endothelial growth factor) with an essential role in angiogenesis. Recent findings suggest that posttranslational proteolytic cleavage of VEGF receptors may be an important mechanism
Evans, I M +7 more
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The role of ADAM17 during liver damage [PDF]
Biological Chemistry, 2021 Abstract A disintegrin and metalloprotease (ADAM) 17 is a membrane bound protease, involved in the cleavage and thus regulation of various membrane proteins, which are critical during liver injury. Among ADAM17 substrates are tumor necrosis factor α (TNFα), tumor necrosis factor receptor 1 and 2 (TNFR1, TNFR2), the epidermal growth ...
Al-Salihi, Mazin +6 more
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Frontiers in Molecular Neuroscience, 2023 IntroductionThe disintegrin and metalloproteinase 17 (ADAM17) exhibits α-secretase activity, whereby it can prevent the production of neurotoxic amyloid precursor protein-α (APP).
Yanna Tian +8 more
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Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2–ADAM17-dependent proteolysis [PDF]
Journal of Cell Science, 2017 ABSTRACT A disintegrin and metalloproteinase 17 (ADAM17) controls the release of the pro-inflammatory cytokine tumor necrosis factor α (TNFα, also known as TNF) and is crucial for protecting the skin and intestinal barrier by proteolytic activation of epidermal growth factor receptor (EGFR) ligands.
Xue Li +8 more
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Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? [PDF]
, 2014 Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell ...
Chuluyan, Hector Eduardo +3 more
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CD9 controls integrin α5β1-mediated cell adhesion by modulating its association with the metalloproteinase ADAM17 [PDF]
, 2018 Integrin α5β1 is a crucial adhesion molecule that mediates the adherence of many cell types to the extracellular matrix through recognition of its classic ligand fibronectin as well as to other cells through binding to an alternative counter-receptor ...
Cabañas, Carlos +10 more
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ADAM17 (ADAM metallopeptidase domain 17) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on ADAM17 (ADAM metallopeptidase domain 17), with data on DNA, on the protein encoded, and where the gene is implicated.
Evers, A, Reiss, K
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ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells.
PLoS ONE, 2015 Tumor-associated lymphatic vessels actively participate in tumor progression and dissemination. ADAM17, a sheddase for numerous growth factors, cytokines, receptors, and cell adhesion molecules, is believed to promote tumor development, facilitating both
Renata Mężyk-Kopeć +7 more
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Co-Emergence of Specialized Endothelial Cells from Embryonic Stem Cells. [PDF]
, 2018 A well-formed and robust vasculature is critical to the health of most organ systems in the body. However, the endothelial cells (ECs) forming the vasculature can exhibit a number of distinct functional subphenotypes like arterial or venous ECs, as well ...
Douglas, Simone A +6 more
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