A score including ADAM17 substrates correlates to recurring cardiovascular event in subjects with atherosclerosis [PDF]
, 2015 Atherosclerosis disease is a leading cause for mortality and morbidity. The narrowing/rupture of a vulnerable atherosclerotic plaque is accountable for acute cardiovascular events.
Cardellini, M +11 more
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ADAM17 regulates TNFα production by placental trophoblasts [PDF]
Placenta, 2011 Increased trophoblast TNFα production is an important component of placental dysfunction in preeclampsia. However, the mechanism of increased TNFα production in the preeclamptic placenta is largely unknown. ADAM17 is a metallopeptidase that functions as a TNFα converting enzyme.
R, Ma, Y, Gu, L J, Groome, Y, Wang
openaire +2 more sources
Targeting ADAM17 Sheddase Activity in Cancer
Current Drug Targets, 2016 A disintegrin and metalloprotease (ADAM)17 is a sheddase, capable of releasing the ectodomains of membrane proteins such as growth factors (e.g. Epidermal Growth Factor Receptor ligands), cytokines and their receptors, adhesion and signaling molecules.
ROSSELLO, ARMANDO +3 more
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The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence [PDF]
, 2015 Proteomic analysis of the secretome of p95HER2-induced senescence. a MCF7 Tet-Off p95HER2 cells were cultured with or without doxycycline for 1 week and stained for senescence-associated β-galactosidase.
Arribas, Joaquín V +4 more
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Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735. [PDF]
PLoS ONE, 2012 ADAM17 (a disintegrin and metalloproteinase) is a membrane-anchored metalloproteinase that regulates the release of EGFR-ligands, TNFα and other membrane proteins from cells.
Katherine C Hall, Carl P Blobel
doaj +1 more source
Molecular Metabolism, 2023 Objective: The metalloprotease ADAM17 (also called TACE) plays fundamental roles in homeostasis by shedding key signaling molecules from the cell surface.
Abdulbasit Amin +17 more
doaj +1 more source
Epithelial cell ADAM17 activation by Helicobacter pylori: role of ADAM17 C-terminus and Threonine-735 phosphorylation [PDF]
Microbes and Infection, 2015 Helicobacter pylori transactivates the epidermal growth factor receptor (EGFR) on gastric epithelial cells via a signalling cascade involving a disintegrin and metalloprotease 17 (ADAM17) cleavage of membrane bound heparin binding-epidermal growth factor (HB-EGF). The effects of H.
McClurg UL +5 more
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Exosome-Derived ADAM17 Promotes Liver Metastasis in Colorectal Cancer
Frontiers in Pharmacology, 2021 Exosomes derived from cancer cells are deemed important drivers of pre-metastatic niche formation at distant organs, but the underlying mechanisms of their effects remain largely unknow.
Jinbing Sun +9 more
doaj +1 more source
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation [PDF]
, 2012 ADAM17 (a disintegrin and metalloproteinase 17) is ubiquitously expressed and cleaves membrane proteins, such as epidermal growth factor receptor (EGFR) ligands, l-selectin, and TNF, from the cell surface, thus regulating responses to tissue injury and ...
Blobel, C.P. +9 more
core +1 more source