Results 61 to 70 of about 22,445 (222)
BMEMat, EarlyView.This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam +4 more
wiley +1 more source
Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice [PDF]
, 2015 ADAM10, as the sheddase of the low affinity IgE receptor (CD23), promotes IgE production and thus is a unique target for attenuating allergic disease. Herein, we describe that B cell levels of ADAM10, specifically, are increased in allergic patients and ...
AA Dussault +31 more
core +9 more sources
Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]
, 2015 Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni +67 more
core +1 more source
The role of ADAM17 in metabolic inflammation [PDF]
Atherosclerosis, 2013 The TNF-alpha Converting Enzyme (TACE), also called ADAM17 (A Disintegrin and A Metalloproteinase 17) is a type I transmembrane metalloproteinase involved in the shedding of the extracellular domain of several transmembrane proteins such as cytokines, growth factors, receptors and adhesion molecules.
MENGHINI, ROSSELLA +4 more
openaire +5 more sources
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
Heliyon, 2020 A disintegrin and metalloprotease 17 (ADAM17) catalyzes the cleavage and release of the ectodomains of its substrates at the cell surface in a process termed ectodomain shedding. However, not all ADAM17 substrates have been identified. Here, we used cell
Kazuki Omoteyama +7 more
doaj +1 more source
MicroRNA‐152 targets ADAM17 to suppress NSCLC progression [PDF]
FEBS Letters, 2014 MicroRNAs (miRNAs) are a class of small non‐coding RNAs that have been suggested to play an essential role in tumorigenesis. In this study, we show that miR‐152 is significantly downregulated in non‐small cell lung cancer (NSCLC) tissues and cell lines. Restoration of miR‐152 significantly reduces proliferation, colony formation, migration and invasion
Su, Yunshu +4 more
openaire +2 more sources
Med Research, EarlyView.ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source
Semaphorin 7A as a potential immune regulator and promising therapeutic target in rheumatoid arthritis [PDF]
, 2017 Background Semaphorin 7A (Sema7A) is expressed by several different classes of lymphoid and myeloid cells and is a potent immunomodulator.
Hao Wang, Jianmin Xie
core +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet +8 more
wiley +1 more source