Results 71 to 80 of about 22,445 (222)

Analysis of ADAM17 Polymorphisms and Susceptibility to Sporadic Abdominal Aortic Aneurysm

Cellular Physiology and Biochemistry, 2014
Background: Accumulating evidence suggests that the principal TNF-α converting enzyme, a disintegrin and metalloproteinase 17 (ADAM17), is involved in the development of human abdominal aortic aneurysm (AAA).
You Li, Cheng Yang, Guoda Ma, Lili Cui, Xuefeng Gu, Yanyan Chen, Bin Zhao, Haiyang Wang, Keshen Li   +8 more
doaj   +1 more source

Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1

Scientific Reports, 2021
A disintegrin and metalloprotease 17 (ADAM17) is the major sheddase that processes more than 80 substrates, including tumour necrosis factor-α (TNFα). The homozygous genetic deficiency of ADAM17 causing a complete loss of ADAM17 expression was reported ...
Issei Imoto, Masako Saito, Kenichi Suga, Tomohiro Kohmoto, Masanobu Otsu, Keisuke Horiuchi, Hironao Nakayama, Shigeki Higashiyama, Mayumi Sugimoto, Ayumi Sasaki, Yukako Homma, Miki Shono, Ryuji Nakagawa, Yasunobu Hayabuchi, Shoichiro Tange, Shoji Kagami, Kiyoshi Masuda   +16 more
doaj   +1 more source

Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals

Integrative Zoology, EarlyView.
This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley   +1 more source

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

eLife, 2018
Many intercellular signals are synthesised as transmembrane precursors that are released by proteolytic cleavage (‘shedding’) from the cell surface. ADAM17, a membrane-tethered metalloprotease, is the primary shedding enzyme responsible for the release ...
Ulrike Künzel, Adam Graham Grieve, Yao Meng, Boris Sieber, Sally A Cowley, Matthew Freeman   +5 more
doaj   +1 more source

A Janus role for MerTK in the outcome of septic shock [PDF]

, 2013
N
COSSARIZZA, Andrea, GIRARDIS, Massimo
core   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

Association of miRNA122 & ADAM17 with lipids among hypertensives in Nigeria

Open Medicine, 2018
Dyslipidaemia and hypertension are established major risk factors for cardiovascular diseases. The suggested roles of miRNA-122 and ADAM17 in lipid metabolism can therefore be applied in the management of metabolic disorders.
Meka Ijeoma A., Anyim Obumneme B., Enebe Joseph T., Ukwaja Kingsley N., Ugonabo Martin C.   +4 more
doaj   +1 more source

Protective effect of metformin against lithium-induced cerebral neurotoxicity in rats

Medicine Science, 2021
Neurotoxic effects are seen in patients using lithium regardless of dose. The neuroprotective activity of metformin used in the treatment of patients with type 2 diabetes mellitus is known.
Umit Ali Malcok, Muserref Hilal Sehitoglu, Basak Buyuk, Eyup Burak Sancak, Halil Ibrahim Tas   +4 more
doaj   +1 more source

Redox regulation of inflammatory processes is enzymatically controlled [PDF]

, 2017
Redox regulation depends on the enzymatically controlled production and decay of redox active molecules. NADPH oxidases, superoxide dismutases, nitric oxide synthases, and others produce the redox active molecules superoxide, hydrogen peroxide, nitric ...
Bekeschus, Sander, Hanschmann, Eva-Maria, Lorenzen, Inken, Mullen, Lisa   +3 more
core   +3 more sources

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source