Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations [PDF]
Advanced ScienceADAM10 is a crucial membrane‐bound metalloprotease that regulates cellular physiology by cleaving and releasing membrane‐anchored proteins, including adhesion molecules and growth factor precursors, thereby modulating cell signaling, adhesion, and ...
Adrien Schahl +7 more
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ADAM10: Possible functions in enamel development
Frontiers in Physiology, 2022 ADAM10 is A Disintegrin And Metalloproteinase (ADAM) family member that is membrane bound with its catalytic domain present on the cell surface. It is a sheddase that cleaves anchored cell surface proteins to shed them from the cell surface.
Shifa Shahid +3 more
doaj +3 more sources
A Functional Role for ADAM10 in Human Immunodeficiency Virus Type-1 Replication [PDF]
Retrovirology, 2011 Background Gene trap insertional mutagenesis was used as a high-throughput approach to discover cellular genes participating in viral infection by screening libraries of cells selected for survival from lytic infection with a variety of viruses.
Rubin Donald H +7 more
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Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice. [PDF]
PLoS ONE, 2015 ADAM10, as the sheddase of the low affinity IgE receptor (CD23), promotes IgE production and thus is a unique target for attenuating allergic disease. Herein, we describe that B cell levels of ADAM10, specifically, are increased in allergic patients and ...
Lauren Folgosa Cooley +6 more
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Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes. [PDF]
PLoS ONE, 2015 BackgroundThe receptor for advanced glycation end products (RAGE) is involved in the pathogenesis of diabetic complications, and soluble forms of the receptor (sRAGE) can counteract the detrimental action of the full-length receptor by acting as decoy ...
Alan C H Lee +5 more
doaj +2 more sources
ADAM10 regulates transcription factor expression required for plasma cell function. [PDF]
PLoS ONE, 2012 A disintegrin and metalloprotease 10 (ADAM10) is a key regulator of cellular processes by shedding extracellular domains of transmembrane proteins. We have previously demonstrated that deletion of B cell expressed ADAM10 results in changes in lymphoid ...
Natalia S Chaimowitz +3 more
doaj +5 more sources
Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies. [PDF]
Adv Healthc MaterFour extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Preußer C +10 more
europepmc +2 more sources
Interfered long non-coding RNA HELLPAR or up-regulated microRNA-448 inhibits nasopharyngeal carcinoma progression via suppression of ADAM10 [PDF]
Discover OncologyObjective Nasopharyngeal carcinoma (NPC) is a highly invasive malignancy with poor prognosis, necessitating further exploration of its molecular mechanisms.
Wenjuan Zhu +5 more
doaj +2 more sources
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]
, 2009 L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Riedle, Svenja +6 more
core +2 more sources
Open Life Sciences, 2021 The present research was designed to examine the effects of disintegrin metalloproteinases 10 (ADAM10) on the doxorubicin (DOX)-induced dilated cardiomyopathy (DCM) and the mechanisms involved, with a focus on ADAM10-dependent cleavage of N-cadherin. The
Li Xiaoou +3 more
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