VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy- Terminal NRP1 Fragments That Regulate Angiogenic Signaling [PDF]
, 2018 OBJECTIVE: NRP1(neuropilin-1) acts as a coreceptor for VEGF (vascular endothelial growth factor) with an essential role in angiogenesis. Recent findings suggest that posttranslational proteolytic cleavage of VEGF receptors may be an important mechanism
Evans, I M +7 more
core +3 more sources
Attenuation of oxidative stress-induced neuronal cell death by Hydnophytum formicarum Jack.
Asian Pacific Journal of Tropical Medicine, 2018 Objective: To investigate protective effects of Hydnophytum formicarum Jack. (H. formicarum) extracts via regulation of SIRT1-FOXO3a-ADAM10 signaling and antioxidant activity against H2O2-induced neurotoxicity in neuroblastoma SH-SY5Y cells.
Naw Hser Gay +6 more
doaj +1 more source
Journal of Diabetes, 2022 Background As a type 1 transmembrane protein, a disintegrin and metalloprotease 10 (ADAM10) is responsible for the cleavage of a variety of cell surface molecules and has been implicated in the pathogenesis of Alzheimer disease, atherosclerosis, and ...
Sum Lam +3 more
doaj +1 more source
ADAM10 mediates malignant pleural mesothelioma invasiveness [PDF]
Oncogene, 2019 Oncogene : including Oncogene reviews 38(18), 3521-3534 (2019).
Sepult, Christelle +9 more
openaire +4 more sources
NrCAM is a marker for substrate‐selective activation of ADAM10 in Alzheimer's disease
EMBO Molecular Medicine, 2019 The metalloprotease ADAM10 is a drug target in Alzheimer's disease, where it cleaves the amyloid precursor protein (APP) and lowers amyloid‐beta. Yet, ADAM10 has additional substrates, which may cause mechanism‐based side effects upon therapeutic ADAM10 ...
Tobias Brummer +7 more
doaj +1 more source
Tight Junction Assembly Ensures Maintenance of Pregnancy during Embryogenesis in a Mouse Model
Journal of Animal Reproduction and Biotechnology, 2019 Recent studies showed that tight junctions (TJs) integrity and assembly are required for blastocyst development in mouse and pig models. However, the biological functions of TJs associated with embryo implantation and maintenance of pregnancy were not ...
Yelin Jeong, Inchul Choi
doaj +1 more source
TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life
Life Science Alliance, 2020 This study demonstrates that the tetraspanins Tspan5 and Tspan15 which directly associate with the metalloprotease ADAM10 have an opposite impact on its endocytosis and half-life.
Etienne Eschenbrenner +8 more
doaj +1 more source
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization [PDF]
Cellular and Molecular Life Sciences, 2015 The metalloprotease ADAM10 mediates the shedding of the ectodomain of various cell membrane proteins, including APP, the precursor of the amyloid peptide Aβ, and Notch receptors following ligand binding. ADAM10 associates with the members of an evolutionary conserved subgroup of tetraspanins, referred to as TspanC8, which regulate its exit from the ...
Jouannet, Stéphanie +8 more
core +4 more sources
ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis
International Journal of Molecular Sciences, 2022 A disintegrin and metalloproteinase (ADAM) family proteins, acting as sheddases, are important factors in a number of pathologies, including cancer, and have been suggested as promising therapeutic targets. The study presented focuses on the involvement of ADAM10 and ADAM17 in retinoblastoma (RB), the most common malignant intraocular childhood tumor ...
Dario Van Meenen +10 more
openaire +4 more sources