shRNAs targeting mouse Adam10 diminish cell response to proinflammatory stimuli independently of Adam10 silencing [PDF]
Biology Open, 2022 RNA interference is one of the common methods of studying protein functions. In recent years critical reports have emerged indicating that off-target effects may have a much greater impact on RNAi-based analysis than previously assumed.
Maria Czarnek +3 more
doaj +4 more sources
Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice [PDF]
BMC Genomics, 2009 Background In a transgenic mouse model of Alzheimer disease (AD), cleavage of the amyloid precursor protein (APP) by the α-secretase ADAM10 prevented amyloid plaque formation, and alleviated cognitive deficits.
Postina Rolf +5 more
doaj +3 more sources
The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors [PDF]
International Journal of Molecular Sciences, 2022 The platelet-activating collagen receptor GPVI represents the focus of clinical trials as an antiplatelet target for arterial thrombosis, and soluble GPVI is a plasma biomarker for several human diseases. A disintegrin and metalloproteinase 10 (ADAM10) acts as a ‘molecular scissor’ that cleaves the extracellular region from GPVI and many other ...
Chek Ziu Koo +7 more
openaire +4 more sources
ADAM10 negatively regulates neuronal differentiation during spinal cord development. [PDF]
PLoS ONE, 2014 Members of the ADAM (a disintegrin and metalloprotease) family are involved in embryogenesis and tissue formation via their proteolytic function, cell-cell and cell-matrix interactions.
Xin Yan +7 more
doaj +1 more source
PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells [PDF]
, 2011 PAX transcription factors play an important role during development and carcinogenesis. In this study, we investigated PAX2 protein levels in melanocytes and melanoma cells by Western Blot and immunofluorescence analysis and characterized the role of ...
Lee, Sophia Boyoung +11 more
core +7 more sources
Cancer Cell International, 2020 Background Osteosarcoma is a malignant bone tumor. Increasing evidences have revealed that a disintegrin and metalloproteinase 10 (ADAM10) is implicated in tumor development.
Quan Yuan +4 more
doaj +1 more source
ADAM10 Localization in Temporomandibular Joint Disk with Internal Derangement: An Ex Vivo Immunohistochemical Study [PDF]
, 2016 The purpose of this study was to determine the presence of ADAM10 in temporomandibular joint disk with internal derangement. Twenty-five paraffin blocks of displaced temporomandibular joint (TMJ) disk specimens from earlier investigations were retrieved ...
Almeida, Luis Eduardo +7 more
core +2 more sources
Protective effect of metformin against lithium-induced cerebral neurotoxicity in rats
Medicine Science, 2021 Neurotoxic effects are seen in patients using lithium regardless of dose. The neuroprotective activity of metformin used in the treatment of patients with type 2 diabetes mellitus is known.
Umit Ali Malcok +4 more
doaj +1 more source
eLife, 2016 Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer's disease
Peer-Hendrik Kuhn +14 more
doaj +1 more source
A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development. [PDF]
PLoS ONE, 2016 ADAM10 and ADAM17 are two closely related members of the ADAM (a disintegrin and metalloprotease) family of membrane-bound sheddases, which proteolytically cleave surface membrane proteins.
Joseph A Toonen +2 more
doaj +1 more source