Results 41 to 50 of about 22,161 (218)

ADAM10 (ADAM metallopeptidase domain 10) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on ADAM10 (ADAM metallopeptidase domain 10), with data on DNA, on the protein encoded, and where the gene is implicated.
Gelebart, P, Armanious, H, Lai, R
openaire   +2 more sources

Dapagliflozin Inhibits Cell Adhesion to Collagen I and IV and Increases Ectodomain Proteolytic Cleavage of DDR1 by Increasing ADAM10 Activity

Molecules, 2020
Dapagliflozin, empagliflozin, tofogliflozin, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2), is used clinically to reduce circulation glucose levels in patients with type 2 diabetes mellitus by blocking the reabsorption of glucose by the ...
Junichi Okada, Eijiro Yamada, Tsugumichi Saito, Hideaki Yokoo, Aya Osaki, Yoko Shimoda, Atsushi Ozawa, Yasuyo Nakajima, Jeffrey E. Pessin, Shuichi Okada, Masanobu Yamada   +10 more
doaj   +1 more source

Differentially-Expressed Pseudogenes in HIV-1 Infection. [PDF]

, 2015
Not all pseudogenes are transcriptionally silent as previously thought. Pseudogene transcripts, although not translated, contribute to the non-coding RNA pool of the cell that regulates the expression of other genes.
Adami, Christoph, Brown, C Titus, Gupta, Aditi, Zheng, Yong-Hui   +3 more
core   +2 more sources

Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5’UTR and PI3K Signaling

Frontiers in Molecular Neuroscience, 2018
The α-secretase “a disintegrin and metalloproteinase domain-containing protein” (ADAM10) is involved in the processing of amyloid precursor protein (APP). Upregulation of ADAM10 precludes the generation of neurotoxic β-amyloid protein (Aβ) and represents
Zhuo Min, Ying Tang, Xiao-Tong Hu, Bing-Lin Zhu, Yuan-Lin Ma, Jing-Si Zha, Xiao-Juan Deng, Zhen Yan, Guo-Jun Chen   +8 more
doaj   +1 more source

Emphysema Mediated by Lung Overexpression of ADAM10 [PDF]

Clinical and Translational Science, 2009
AbstractCigarette smoking is the major risk factor for emphysema, a disorder of the lung parenchyma characterized by destruction of the alveolar walls. Current concepts of the pathogenesis of emphysema hold that the destruction of the lung parenchyma results, in part, from a local imbalance of proteases and antiproteases.
Hiroki, Saitoh, Philip L, Leopold, Ben-Gary, Harvey, Timothy P, O'Connor, Stefan, Worgall, Neil R, Hackett, Ronald G, Crystal   +6 more
openaire   +2 more sources

ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development. [PDF]

PLoS ONE, 2016
ADAM10 (A Disintegrin and Metalloprotease domain-containing protein 10) is a cell surface protein with a unique structure possessing both potential adhesion and protease domains.
Jeongwoo Kwon, Sung-min Jeong, Inchul Choi, Nam-Hyung Kim   +3 more
doaj   +1 more source

Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain [PDF]

, 2011
Objectives: The thickness of the brain’s cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated
Anderson eWinkler, David eGlahn, David eGlahn, Elliott eHong, Henry eHolcomb, Jack eKent, Jason eStein, Joanne eCurran, John eBlangero, Melany eCarless, MP eJohnson, Paul eThompson, Peter eKochunov, Peter eKochunov, Peter eKochunov, Rene eOlvera, Shelley eCole, Tom eNichols, Valeria eKochunov   +18 more
core   +4 more sources

ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc

Cancer Cell International, 2021
Background Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat, because it is so aggressive with shorter survival.
Yuanyuan Cheng, Lishuang Lin, Xiaoyan Li, Aiqi Lu, Chenjian Hou, Qian Wu, Xiaomu Hu, Zhongwen Zhou, Zhongqing Chen, Feng Tang   +9 more
doaj   +1 more source

Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? [PDF]

, 2014
Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell ...
Chuluyan, Hector Eduardo, Gallo, Juan Eduardo Maria, Ortiz, Gustavo Alfredo, Salica, Juan Pablo   +3 more
core   +1 more source

Tetraspanin-Mediated ADAM10 Regulation in Sepsis and Potential Therapeutic Implications

Frontiers in Bioscience-Landmark
Excessive inflammatory responses in sepsis result in multiorgan dysfunction, with the majority of these responses being modulated by the activity of a disintegrin and metalloproteinase 10 (ADAM10).
Meiting Yang, Yao Lin, Yufu He, Shuanglin Liao, Yuting Qin, Lizhen Liu, Junbing He, Yiming Shao   +7 more
doaj   +1 more source