Results 51 to 60 of about 22,161 (218)

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome [PDF]

, 2016
© 2015 Elsevier Inc. The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS).
Bagni, Claudia, Dotti, Carlos G., Pasciuto, Emanuela   +2 more
core   +1 more source

The ADAM10 Prodomain Is a Specific Inhibitor of ADAM10 Proteolytic Activity and Inhibits Cellular Shedding Events [PDF]

Journal of Biological Chemistry, 2007
ADAM10 is a disintegrin metalloproteinase that processes amyloid precursor protein and ErbB ligands and is involved in the shedding of many type I and type II single membrane-spanning proteins. Like tumor necrosis factor-alpha-converting enzyme (TACE or ADAM17), ADAM10 is expressed as a zymogen, and removal of the prodomain results in its activation ...
Marcia L, Moss, Martha, Bomar, Qian, Liu, Harvey, Sage, Peter, Dempsey, Patricia M, Lenhart, Patricia A, Gillispie, Alexander, Stoeck, Dirk, Wildeboer, Jörg W, Bartsch, Ralf, Palmisano, Pei, Zhou   +11 more
openaire   +2 more sources

ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases

Journal of Biomedical Science, 2010
Background The importance of the Notch signaling in the development of glomerular diseases has been recently described. Therefore we analyzed in podocytes the expression and activity of ADAM10, one important component of the Notch signaling complex ...
Weide Thomas, Hillmann Anja, Gauer Stefan, Altevogt Peter, Ludwig Andreas, Hauser Ingeborg A, Doberstein Kai, Abdel-Bakky Mohamed, Schramme Anja, Gutwein Paul, Jespersen Christine, Eberhardt Wolfgang, Pfeilschifter Josef   +12 more
doaj   +1 more source

A Disintegrin and Metalloprotease 10 Expressions Modulate Potential Metastatic and Thrombus Formation in Pancreatic Carcinoma

Iranian Journal of Public Health, 2022
Background: Clinical investigations repurposing a disintegrin and metalloproteases 10 (ADAM10) as metastatic and thrombus marker have achieved encouraging results, but the mechanism behind this association remains unclear.
Miao Yu, Quan Chen, Qin Li, Yunfei Teng, Lin Xiao, Guang Yang, Chenxi Ouyang, Ahmed Mohammed Elamin Abdalla   +7 more
doaj   +1 more source

Targeting self-renewal pathways in myeloid malignancies [PDF]

, 2013
A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Targeting of Retinal Axons Requires the Metalloproteinase ADAM10 [PDF]

The Journal of Neuroscience, 2007
The role of extrinsic cues in guiding developing axons is well established; however, the means by which the activity of these extrinsic cues is regulated is poorly understood. A disintegrin and metalloproteinase (ADAM) enzymes are Zn-dependent proteinases that can cleave guidance cues or their receptorsin vitro. Here, we identify the first example of a
Yuanyuan Y, Chen, Carrie L, Hehr, Karen, Atkinson-Leadbeater, Jennifer C, Hocking, Sarah, McFarlane   +4 more
openaire   +2 more sources

ErbB3 Phosphorylation as Central Event in Adaptive Resistance to Targeted Therapy in Metastatic Melanoma. Early Detection in CTCs during Therapy and Insights into Regulation by Autocrine Neuregulin [PDF]

, 2019
In recent years the introduction of target therapies with BRAF and MEK inhibitors (MAPKi) and of immunotherapy with anti-CTLA-4 and anti-PD-1 monoclonal antibodies have dramatically improved survival of metastatic melanoma patients. Despite these changes
Ascierto, Paolo Antonio, Bedogni, Barbara, Capone, Mariaelena, Ciliberto, Gennaro, Fattore, Luigi, Liguoro, Domenico, Madonna, Gabriele, Mallardo, Domenico, Malpicci, Debora, Mancini, Rita, Ruggiero, Ciro Francesco, Salvati, Valentina, Vanella, Vito   +12 more
core   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

miR-23b Negatively Regulates Sepsis-Induced Inflammatory Responses by Targeting ADAM10 in Human THP-1 Monocytes

Mediators of Inflammation, 2019
Background. Previous studies have demonstrated pivotal roles of disintegrin and metalloproteinase 10 (ADAM10) in the pathogenesis of sepsis. MicroRNA- (miR-) 23b has emerged as an anti-inflammatory factor that prevents multiple autoimmune diseases ...
Wenying Zhang, Furong Lu, Yuliu Xie, Yao Lin, Tian Zhao, Shoubao Tao, Zhipeng Lai, Ning Wei, Ruoxuan Yang, Yiming Shao, Junbing He   +10 more
doaj   +1 more source