Results 61 to 70 of about 22,161 (218)

Role of redox-sensitive catalytic interaction with ADAM10 in mutant-selective extracellular shedding of prion protein

Redox Biology, 2022
Misfolded glycosylphosphatidylinositol-anchored prion protein (PrP) is primarily degraded in lysosomes but is often rapidly removed from the cell surface before endocytosis in a preemptive manner. However, this mechanism is poorly understood.
Yejin Shin, Kang-Sug Jo, Minseok Shin, Duri Lee, Hyejin Yeo, Youngsup Song, Sang-Wook Kang   +6 more
doaj   +1 more source

Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity [PDF]

, 2016
Staphylococcus aureus causes a wide variety of infections and antibiotic resistant strains are a major problem in hospitals. One of the best studied virulence factors of S.
Bardoel, Bart W., Winter, Sebastian Virreira, Zychlinsky, Arturo   +2 more
core   +2 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. [PDF]

, 2018
We describe here the results from the testing of a small molecule first-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, A03, that increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic ...
Bai, Dongsheng, Bilousova, Tina, Bredesen, Dale E, Campagna, Jesus, Cole, Gregory, Elias, Chris Jean, Hatami, Asa, Jagodzinska, Barbara, John, Varghese, Jun, Michael, Jung, Michael E, LaDu, Mary Jo, Pham, Johnny, Spilman, Patricia, Zhu, Chunni   +14 more
core   +3 more sources

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

ADAM10 and BACE1 are localized to synaptic vesicles [PDF]

Journal of Neurochemistry, 2015
AbstractSynaptic degeneration and accumulation of the neurotoxic amyloid β‐peptide (Aβ) in the brain are hallmarks of Alzheimer disease. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP), by the β‐secretase β‐site APP cleaving enzyme 1 (BACE1) and γ‐secretase.
Jolanta L. Lundgren, Saheeb Ahmed, Sophia Schedin‐Weiss, Gunnar K. Gouras, Bengt Winblad, Lars O. Tjernberg, Susanne Frykman   +6 more
openaire   +2 more sources

Regulation of Leukocytes by TspanC8 Tetraspanins and the “Molecular Scissor” ADAM10

Frontiers in Immunology, 2018
A disintegrin and metalloproteinase 10 (ADAM10) is a ubiquitous transmembrane protein that functions as a “molecular scissor” to cleave the extracellular regions from its transmembrane target proteins. ADAM10 is well characterized as the ligand-dependent
Alexandra L. Matthews, Chek Ziu Koo, Chek Ziu Koo, Justyna Szyroka, Neale Harrison, Aditi Kanhere, Michael G. Tomlinson, Michael G. Tomlinson   +7 more
doaj   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein [PDF]

, 2011
Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24–204), expressed and characterized from
Amour, Arribas, Bartsch, Black, Cissé, Crawford, De Strooper, Edwards, Fassold, Geretti, Gonzales, Gray, Hass, Hirahashi, Koller, Kuhn, Kveiborg, Lee, Lemieux, Leon, Leonard, Lichtenthaler, Liu, Matei, Miller, Morrison, Moss, Moss, Moss, Moss, Moss, Murphy, Nasarre, Naus, Nocentini, Pan, Postina, Rose, Rose, Saftig, Sahin, Sunnarborg, Tape, Taylor, Tousseyn, Turner, Turtinen, Weskamp, Weskamp, Zhao, Zhou, Zhou   +51 more
core   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source