Results 31 to 40 of about 22,161 (218)
ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]
, 2008 ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Burkhardt, Harald +2 more
core +1 more source
PLoS Pathogens, 2023 Hepatitis C virus (HCV) exploits the four entry factors CD81, scavenger receptor class B type I (SR-BI, also known as SCARB1), occludin, and claudin-1 as well as the co-factor epidermal growth factor receptor (EGFR) to infect human hepatocytes.
Belén Carriquí-Madroñal +8 more
doaj +1 more source
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation
Journal of Neuroinflammation, 2018 Background Mice with pilocarpine-induced temporal lobe epilepsy (TLE) are characterized by intense hippocampal neuroinflammation, a prominent pathological hallmark of TLE that is known to contribute to neuronal hyperexcitability.
Xinjian Zhu +8 more
doaj +1 more source
CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]
, 2009 Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Abdel-Aziz, Abdel-Aziz H. +11 more
core +1 more source
Aberrant ADAM10 expression correlates with osteosarcoma progression [PDF]
European Journal of Medical Research, 2014 Osteosarcoma is the most common type of bone cancer and is notorious for its rapid progression. The Notch signaling pathway has recently been shown to be involved in osteosarcoma. As a major sheddase of Notch receptors, ADAM10 has been implicated in many types of cancers, but its role in osteosarcoma has not been investigated.
Zhao, Ren +4 more
openaire +2 more sources
The role of ADAM10 in the prediction of neoadjuvant chemoradiotherapy response in patients with locally advanced rectal cancer [PDF]
Archives of Biological SciencesProtease ADAM10, a member of the A disintegrin and metalloproteinase protein family, plays a role in cytokine/ growth factor release, the shedding of receptor molecules from the membrane, and intracellular signaling.
Isaković Anđelka M. +6 more
doaj +1 more source
ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis
Scientific Reports, 2021 ADAM10 and ADAM17 are proteases that affect multiple signalling pathways by releasing molecules from the cell surface. As their substrate specificities partially overlaps, we investigated their concurrent role in liver regeneration and fibrosis, using ...
Olga Zbodakova +6 more
doaj +1 more source
Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein [PDF]
, 2016 Despite existing knowledge about the role of the A Disintegrin and Metalloproteinase 10 (ADAM10) as the α-secretase involved in the non-amyloidogenic processing of the amyloid precursor protein (APP) and Notch signalling we have only limited information ...
Altmeppen, Hermann +10 more
core +1 more source
Frontiers in Cellular Neuroscience, 2019 ADAM10, a member of the disintegrin and metalloproteinase domain-containing protein (ADAM) family, has been reported to mediate proteolytic shedding of cell surface proteins.
Xinjian Zhu +8 more
doaj +1 more source
Engineering, 2023 Host-directed therapy (HDT) is an emerging novel approach for treating multidrug-resistant Staphylococcus aureus (S. aureus) infection. Functioning as the indispensable specific cellular receptor for α-toxin (Hla), a-disintegrin and metalloproteinase 10 (
Tingting Wang +8 more
doaj +1 more source