Results 41 to 50 of about 22,445 (222)

The role of EphA2 in ADAM17- and ionizing radiation-enhanced lung cancer cell migration

Frontiers in Oncology, 2023
PurposeIonizing radiation (IR) enhances the migratory capacity of cancer cells. Here we investigate in non-small-cell-lung-cancer (NSCLC) cells a novel link between IR-enhanced ADAM17 activity and the non-canonical pathway of EphA2 in the cellular stress
Verena Waller, Fabienne Tschanz, Rona Winkler, Martin Pruschy   +3 more
doaj   +1 more source

The role of NF-κB and Elk-1 in the regulation of mouse ADAM17 expression

Biology Open, 2019
ADAM17 is a cell membrane metalloproteinase responsible for the release of ectodomains of numerous proteins from the cell surface. Although ADAM17 is often overexpressed in tumours and at sites of inflammation, little is known about the regulation of its
Karolina Wawro, Mateusz Wawro, Magdalena Strzelecka, Maria Czarnek, Joanna Bereta   +4 more
doaj   +1 more source

Cardiomyocyte cohesion is increased after ADAM17 inhibition

Frontiers in Cell and Developmental Biology, 2023
A Disintegrin And Metalloprotease (ADAM) family proteins are involved in several cardiac diseases, and some ADAMs have been associated with cardiomyopathies. ADAM17 is known to cleave desmoglein 2 (DSG2), one of the proteins involved in the pathogenesis of arrhythmogenic cardiomyopathy (AC).
Maria Shoykhet, Jens Waschke, Sunil Yeruva   +2 more
openaire   +3 more sources

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. [PDF]

, 2018
Hyperproliferative keratinocytes induced by trauma, hyperkeratosis and/or inflammation display molecular signatures similar to those of palmoplantar epidermis.
Arcidiacono, P, Blaydon, DC, Brooke, MA, Chikh, A, Delaney, PJ, Kelsell, DP, Ng, K-E, Tinker, A, Webb, CM, Zhou, H   +9 more
core   +2 more sources

How membrane asymmetry regulates ADAM17 sheddase function [PDF]

Cell Cycle, 2016
Asymmetrical distribution of lipids in the cell membrane is a fundamental feature of all eukaryotic cells. The most important negatively charged phospholipids phosphatidylserine (PS) and phosphatidylinositol species reside almost exclusively in the cytoplasmic leaflet, where they serve as essential co-factors for many membrane-bound enzymes including ...
Sommer, Anselm, Bhakdi, Sucharit, Reiss, Karina   +2 more
openaire   +2 more sources

ADAM17: A novel treatment target for aneurysms

Biomedicine & Pharmacotherapy, 2022
The mechanisms underlying abdominal aortic aneurysms (AAAs) are still not fully understood, previous researches showed ADAM17 is increased in aneurysm. We hypothesized that inhibiting ADAM17 can decrease AAA formation and progression.Aneurysm models were established in mouses and rats by aortic adventitial CaCl2 incubation and aortic pericardial patch ...
Hualong, Bai, Liwei, Zhang, Peng, Sun, Haoliang, Wu, Mingxing, Li, Yulei, Gu, Cong, Zhang, Chunyang, Lou, Jing'an, Li   +8 more
openaire   +2 more sources

Tissue Inhibitor of Metalloproteinase–3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells [PDF]

, 2018
Over expression of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in vascular smooth muscle cells (VSMCs) induces apoptosis and reduces neointima formation occurring after saphenous vein interposition grafting or coronary stenting.
Baker, Andrew H., Bennett, Martin R., English, William R., Ireland-Zecchini, Heather, Littlewood, Trevor D., Murphy, Gillian   +5 more
core   +4 more sources

Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation

EBioMedicine, 2016
Epithelial regeneration is a key process for the recovery from ulcerative colitis (UC). Here we demonstrate that a disintegrin and metalloproteinase-17 (ADAM17), a main sheddase for tumor necrosis factor (TNF)-α, is essential for defensive epithelial ...
Masayuki Shimoda, Keisuke Horiuchi, Aya Sasaki, Tetsuya Tsukamoto, Koji Okabayashi, Hirotoshi Hasegawa, Yuko Kitagawa, Yasunori Okada   +7 more
doaj   +1 more source

Fat mass and obesity–mediated N6-methyladenosine modification modulates neuroinflammatory responses after traumatic brain injury

Neural Regeneration Research
The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury. The post-transcriptional modification of N6-methyladenosine is ubiquitous in the immune response of the ...
Xiangrong Chen, Jinqing Lai, Zhe Wu, Jianlong Chen, Baoya Yang, Chunnuan Chen, Chenyu Ding   +6 more
doaj   +1 more source

ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

OncoImmunology, 2020
ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The mechanism of soluble PD-L1 production and its effects are unknown.
Jacob J. Orme, Khalid A. Jazieh, Tiancheng Xie, Susan Harrington, Xin Liu, Matthew Ball, Benjamin Madden, M. Cristine Charlesworth, Tariq U. Azam, Fabrice Lucien, Bharath Wootla, Yanli Li, Jose Caetano Villasboas, Aaron S. Mansfield, Roxana S. Dronca, Haidong Dong   +15 more
doaj   +1 more source