Results 21 to 30 of about 22,445 (222)
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]
, 2009 L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Riedle, Svenja +6 more
core +2 more sources
ADAM17 promotes glioma cell malignant phenotype [PDF]
Molecular Carcinogenesis, 2011 AbstractA disintegrin and metalloproteinase‐17 (ADAM17) is involved in proteolytic ectodomain shedding of several membrane‐bound growth factors and cytokines. The expression and activity of ADAM17 increase under some pathological conditions such as stroke and cancer. ADAM17 promotes neural progenitor cell migration and contributes to neurogenesis after
Xuguang, Zheng +4 more
openaire +2 more sources
Role of ADAM17 in kidney disease [PDF]
American Journal of Physiology-Renal Physiology, 2019 It is known that the renin-angiotensin system plays a major role in the pathophysiology of cardiovascular disease and renal injury. Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1–7) peptide, which counteracts the adverse effects of ANG II accumulation.
Vanesa Palau +3 more
openaire +3 more sources
The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth
Life Science Alliance, 2023 The FERM domain protein iTAP/Frmd8, which binds to and stabilizes the ADAM17/iRhom sheddase complex at the cell surface, is a regulator of inflammation, epithelial homeostasis, and tumor growth in vivo.
Marina Badenes +9 more
doaj +1 more source
ADAM17 deletion in thymic epithelial cells alters aire expression without affecting T cell developmental progression. [PDF]
PLoS ONE, 2010 Cellular interactions between thymocytes and thymic stromal cells are critical for normal T cell development. Thymic epithelial cells (TECs) are important stromal niche cells that provide essential growth factors, cytokines, and present self-antigens to ...
David M Gravano +3 more
doaj +1 more source
Structural and functional analyses of the shedding protease ADAM17 in HoxB8-Immortalized macrophages and dendritic-like cells [PDF]
, 2018 A disintegrin and metalloproteinase (ADAM) 17 has been implicated in many shedding processes. Major substrates of ADAM17 are TNF-α, IL-6R, and ligands of the epidermal growth factor receptor.
Arnold, Philipp +13 more
core +2 more sources
TACE (ADAM17) inhibits Schwann cell myelination [PDF]
Nature Neuroscience, 2011 Tumor necrosis factor-α-converting enzyme (TACE; also known as ADAM17) is a proteolytic sheddase that is responsible for the cleavage of several membrane-bound molecules. We report that TACE cleaves neuregulin-1 (NRG1) type III in the epidermal growth factor domain, probably inactivating it (as assessed by deficient activation of the ...
La Marca Rosa +9 more
openaire +2 more sources
Platelet Biochemistry and Morphology after Cryopreservation [PDF]
, 2020 Platelet cryopreservation has been investigated for several decades as an alternative to room temperature storage of platelet concentrates. The use of dimethylsulfoxide as a cryoprotectant has improved platelet storage and cryopreserved concentrates can ...
Compernolle, Veerle +2 more
core +1 more source
Biology Open, 2022 RNA interference is one of the common methods of studying protein functions. In recent years critical reports have emerged indicating that off-target effects may have a much greater impact on RNAi-based analysis than previously assumed.
Maria Czarnek +3 more
doaj +1 more source
ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis
International Journal of Molecular Sciences, 2022 A disintegrin and metalloproteinase (ADAM) family proteins, acting as sheddases, are important factors in a number of pathologies, including cancer, and have been suggested as promising therapeutic targets. The study presented focuses on the involvement of ADAM10 and ADAM17 in retinoblastoma (RB), the most common malignant intraocular childhood tumor ...
Dario Van Meenen +10 more
openaire +4 more sources