Results 11 to 20 of about 22,445 (222)
Leukocyte ADAM17 regulates acute pulmonary inflammation. [PDF]
PLoS ONE, 2011 The transmembrane protease ADAM17 regulates the release and density of various leukocyte cell surface proteins that modulate inflammation, including L-selectin, TNF-α, and IL-6R.
Patrick G Arndt +5 more
doaj +4 more sources
A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries [PDF]
, 2020 Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche
A Buffo +48 more
core +2 more sources
ADAM17 promotes the invasion of hepatocellular carcinoma via upregulation MMP21
Cancer Cell International, 2020 Background The upregulation of ADAM17 has been reported to be associated with invasion and metastasis in various tumors, however the molecular mechanism of ADAM17 in the progression of hepatocellular carcinoma (HCC) remain to be clarified.
Yuqi Xiang +5 more
doaj +1 more source
Frontiers in Immunology, 2022 SARS-Cov-2 caused the COVID-19 pandemic worldwide. ADAM17 functions as a disintegrin and transmembrane metalloproteinase domain protein involved in the regulation of SARS-CoV-2 receptor ACE2.
Kai Wang +12 more
doaj +1 more source
ADAM17 is an essential attachment factor for classical swine fever virus.
PLoS Pathogens, 2021 Classical swine fever virus (CSFV) is an important pathogen in the swine industry. Virion attachment is mediated by envelope proteins Erns and E2, and E2 is indispensable.
Fei Yuan +8 more
doaj +1 more source
The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology [PDF]
, 2018 Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) share molecular mechanisms that cause the pathological symptoms they have in common.
Scholte, B.J. (Bob) +1 more
core +10 more sources
A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells. [PDF]
PLoS ONE, 2012 The disintegrin and metalloenzyme ADAM17 participates in numerous inflammatory and proliferative diseases, and its pathophysiological role was implicated in kidney fibrosis, polycystic kidney disease and other chronic kidney diseases. At present, we have
Pal Gooz +5 more
doaj +1 more source
Arteriosclerosis, Thrombosis, and Vascular Biology, 2017 A disintegrin and metalloproteinase 17 (ADAM17) is a major sheddase of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes, such as tumor necrosis factor-α (TNF-α), transforming growth factor-α, TNF-α receptor 1 (TNFR1), TNF-α receptor 2 (TNFR2), and interleukin-6 receptor, L-selectin, Notch, and angiotensin-converting
Yiting, Jia, Wei, Kong
openaire +2 more sources
Adipocyte ADAM17 plays a limited role in metabolic inflammation
Adipocyte, 2020 The role of ADAM17, its substrates, and its natural inhibitor has been well studied in the context of inflammation, including metabolic inflammation, with mixed results.
Joseph C. Lownik +4 more
doaj +1 more source
Inhibitory monoclonal antibody targeting ADAM17 expressed on cancer cells
Translational Oncology, 2022 ADAM17 is upregulated in many cancers and in turn activates signaling pathways, including EGFR/ErbB, as well as those underlying resistance to targeted anti-EGFR therapies.
Nayanendu Saha +10 more
doaj +1 more source