Results 181 to 190 of about 22,161 (218)

Targeting ADAM10 in Renal Diseases

Current Molecular Medicine, 2023
Abstract: ADAM10 is part of the ADAM superfamily containing cell surface proteins with special structures and potential adhesion and protease domains. This paper provides a review of the specific effects of ADAM10 in kidney development as well as its relations with renal diseases. ADAM10 plays an important role in developing tissues and organs and the
Jie-Na, Wang, Xiao-Jing, Cao
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CSF ADAM10 levels in AD patients in relationship to ADAM10 gene variants

Alzheimer's & Dementia, 2023
AbstractBackgroundThe disintegrin metalloproteinase 10 (ADAM10) is the main α‐secretase acting in the non‐amyloidogenic processing of APP. Some ADAM10 gene variants (Q170H, R181G) have been associated with higher susceptibility to develop late‐onset AD and have been shown to promote AD‐type changes in mice models.
Pablo Agüero, Lucía Cremades‐Jimeno, María‐Salud García‐Ayllón, Adriana Gea‐González, María José Sainz, Raquel Téllez, Blanca Cárdaba, Javier Sáez‐Valero, Julián Pérez‐Pérez, Estrella Gómez‐Tortosa   +9 more
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Improved Synthesis of ADAM10 Inhibitor GI254023X

Neurodegenerative Diseases, 2010
<i>Background:</i> The metalloproteinases ADAM10 and ADAM17 are involved in various diseases: neurodegeneration, cancer and inflammation. <i>Objective:</i> The inhibition of these proteases is a promising target in the treatment of inflammation and cancer.
Nicole, Hoettecke, Andreas, Ludwig, Sabine, Foro, Boris, Schmidt   +3 more
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ADAM10 in Synaptic Physiology and Pathology

Neurodegenerative Diseases, 2013
<b><i>Background:</i></b> Generation of amyloid-β peptide is at the beginning of a cascade that leads to Alzheimer's disease. Amyloid precursor protein (APP) as well as β- and &#947;-secretases are the principal players involved in amyloid-β (Aβ) production, while α-secretase cleavage on APP prevents Aβ deposition.
S. Musardo, E. Marcello, F. Gardoni, M. Di Luca   +3 more
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Degradome of soluble ADAM10 and ADAM17 metalloproteases

Cellular and Molecular Life Sciences, 2019
Disintegrin and metalloproteinases (ADAMs) 10 and 17 can release the extracellular part of a variety of membrane-bound proteins via ectodomain shedding important for many biological functions. So far, substrate identification focused exclusively on membrane-anchored ADAM10 and ADAM17.
Franka Scharfenberg, Andreas Helbig, Martin Sammel, Julia Benzel, Uwe Schlomann, Florian Peters, Rielana Wichert, Maximilian Bettendorff, Dirk Schmidt-Arras, Stefan Rose-John, Catherine Moali, Stefan F. Lichtenthaler, Claus U. Pietrzik, Jörg W. Bartsch, Andreas Tholey, Christoph Becker-Pauly   +15 more
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ADAM10 regulates the ICOS:ICOSL axis

The Journal of Immunology, 2017
Abstract The interaction between inducible costimulator (ICOS) and its ligand (ICOSL) is essential for proper T-dependent humoral immune responses, especially follicular helper T cell (TFH) development. We have demonstrated that A Disintegrin and Metalloproteinase 10 (ADAM10) is the primary and physiological sheddase of ICOSL.
Joseph Cornelius Lownik, Andrea Luker, Rebecca Martin, Sheela Damle, Daniel H Conrad   +4 more
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The Role of ADAM10 in Alzheimer’s Disease

Journal of Alzheimer’s Disease, 2017
As a member of the A Disintegrin And Metalloproteinase (ADAM) family, ADAM10 has been identified as the constitutive α-secretase in the process of amyloid-β protein precursor (AβPP) cleavage and plays a critical role in reducing the generation of the amyloid-β (Aβ) peptides.
Xiang-Zhen, Yuan, Sen, Sun, Chen-Chen, Tan, Jin-Tai, Yu, Lan, Tan   +4 more
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Involvement of ADAM10 in acrolein-induced astrocytic inflammation

Toxicology Letters, 2020
Acrolein is a neurotoxin produced through lipid peroxidation in the brain affected by ischemic stroke, which results in neuronal cell injury and inflammation. However the mechanism underlying acrolein-induced brain inflammation remains unclear. Therefore we examined how acrolein leads to astrocytic inflammation. It was found that acrolein increased the
Jung Hyun, Park, Ji-Young, Choi, Chulman, Jo, Young Ho, Koh   +3 more
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Increased ADAM10 expression in patients with immune thrombocytopenia

International Immunopharmacology, 2018
Immune thrombocytopenia (ITP) is an autoimmune disease, which is characterized by abnormal of T immunity. A disintegrin and metalloproteinase (ADAM) 10, a member of proteinase family, has been demonstrated to regulate T cell proliferation and effector function.
Jianlin, Qiao, Qi, Luo, Na, Liu, Guangyu, Wei, Xiaoqing, Wu, Jun, Lu, Kai, Tang, Yulu, Wu, Jie, Zi, Xiaoqian, Li, Yun, Liu, Wen, Ju, Kunming, Qi, Zhiling, Yan, Zhenyu, Li, Lingyu, Zeng, Kailin, Xu   +16 more
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Localization of ADAM10 and notch receptors in bone

Bone, 1999
In Drosophila melanogaster, the role of the metallodisintegrin, Kuzbanian (kuz), is thought to involve activation of the Drosophila Notch receptor that plays a role in cell-fate determination during neurogenesis and myoblast differentiation. To understand the possible function(s) of a-disintegrin and metalloproteinase (ADAM10), the mammalian ortholog ...
D J, Dallas, P G, Genever, A J, Patton, M I, Millichip, N, McKie, T M, Skerry   +5 more
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