Results 191 to 200 of about 22,161 (218)

ADAM10 as a Target for Anti-Cancer Therapy

Current Pharmaceutical Biotechnology, 2008
There is a great unmet medical need in the area of cancer treatment. A potential therapeutic target for intervention in cancer is ADAM10. ADAM10 is a disintegrin-metalloproteinase that processes membrane bound proteins from the cell surface to yield soluble forms.
Marcia L, Moss, Alexander, Stoeck, Wenbo, Yan, Peter J, Dempsey   +3 more
openaire   +2 more sources

Expression of ADAM17 and ADAM10 in nasal polyps

International Forum of Allergy & Rhinology, 2016
BackgroundThe “a disintegrin and metalloproteases” (ADAMs) are a multifunctional gene family that contribute to the homeostasis of the extracellular matrix, transduction of specific intracellular signals, organogenesis, inflammation, tissue remodeling, adhesion, and cell migration.
Woo Yong, Bae, Seong Kook, Park, Do Hun, Kim, Tae Kyung, Koh, Dae Young, Hur, Hee Won, Chueh   +5 more
openaire   +2 more sources

A Valuable Target for Therapy: The Metalloproteinase ADAM10

Current Protein & Peptide Science
A special kind of posttranslational process known as proteolytic cleavage controls the half-lives and functions of several extracellular and intracellular proteins. The metalloproteinase ADAM10 has attracted attention because it cleaves a growing amount of protein substrates close to the extracellular membrane leaflet.
Siddhant, Tripathi, Yashika, Sharma, Dileep, Kumar   +2 more
openaire   +2 more sources

Structural basis for membrane-proximal proteolysis of substrates by ADAM10

Cell, 2023
Colin Lipper, Stephen C Blacklow
exaly  

Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction

Immunity, 2021
Keiko Sakamoto, Seon-Pil Jin, Jay-Hyun Jo   +2 more
exaly  

ADAM10

2006
Paul Saftig, Dieter Hartmann
openaire   +1 more source

ADAM10, myelin-associated metalloendopeptidase

2004
Rolf Postina, Falk Fahrenholz
openaire   +1 more source

The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer’s disease

Molecular Therapy, 2022
Stefano Musardo, Silvia Pelucchi, Ana Ribeiro   +2 more
exaly  

Adam10 Mediates Malignant Pleural Invasiveness

B68. ONCOGENIC MUTATIONS, METASTASIS, AND NOVEL THERAPEUTICS, 2019
D.D. Cataldo, C. Sepult, M. Bellefroid, B. Duysinx, A. Ludwig, A. Noel   +5 more
openaire   +1 more source

Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential

International Journal of Molecular Sciences, 2021
Neale J Harrison, Chek Ziu Koo, Michael G Tomlinson   +2 more
exaly