Results 51 to 60 of about 8,067,991 (149)
Inhibition of MMPs and ADAM/ADAMTS
Biochemical Pharmacology, 2019 Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc-dependent endopeptidases that play a critical role in the destruction of extracellular matrix
C. Malemud
semanticscholar +1 more source
Proteases at work: Cues for understanding neural development and degeneration
Frontiers in Molecular Neuroscience, 2015 Proteolytical processing of membrane bound molecules is a fundamental mechanism for the degradation of these proteins as well as for controlling cell-to-cell communication, which is at the basis of tissue development and homeostasis.
Paul eSaftig, Paola eBovolenta
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ADAM11 a novel regulator of Wnt and BMP4 signaling in neural crest and cancer
Frontiers in Cell and Developmental Biology, 2023 Introduction: Cranial neural crest (CNC) cells are induced at the border of the neural plate by a combination of FGF, Wnt, and BMP4 signaling. CNC then migrate ventrally and invade ventral structures where they contribute to craniofacial development ...
Ankit Pandey +3 more
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ADAM Proteases in Cancer: Biological Roles, Therapeutic Challenges, and Emerging Opportunities
CancersSimple Summary Cancer remains a leading cause of death worldwide, with metastasis accounting for the majority of fatalities. A family of proteins called ADAM metalloproteases plays important roles in cancer progression by enabling tumour cells to grow ...
Sakshi Arora +2 more
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Homologous high-throughput expression and purification of highly conserved E coli proteins
Microbial Cell Factories, 2007 BackgroundGenetic factors and a dysregulated immune response towards commensal bacteria contribute to the pathogenesis of Inflammatory Bowel Disease (IBD).
Asgar Ergin +5 more
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Biochemical Pharmacology, 2019 A Disintegrin and Metalloproteinase (ADAM) is a family of proteolytic enzymes that possess sheddase function and regulate shedding of membrane-bound proteins, growth factors, cytokines, ligands and receptors.
S. Zhong, R. Khalil
semanticscholar +1 more source
Identification and preliminary characterization of mouse
BMC Genetics, 2002 Background The metalloprotease-disintegrin family, or ADAM, proteins, are implicated in cell-cell interactions, cell fusion, and cell signaling, and are widely distributed among metazoan phyla.
Hyman Richard W +5 more
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The Journal of Poultry ScienceSperm–egg interactions involve a complex series of molecular events. Among these, the acrosome reaction (AR) is a prerequisite for sperm penetration, facilitating the exposure of multiple acrosomal proteins that enhance sperm binding or penetration of ...
Mohamad Shuib Bin Mohamad Mohtar +3 more
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A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions
Toxins, 2016 Since the discovery of the first disintegrin protein from snake venom and the following identification of a mammalian membrane-anchored metalloprotease-disintegrin implicated in fertilization, almost three decades of studies have identified additional ...
Nives Giebeler, Paola Zigrino
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Biomarker Insights, 2021 Cognitive impairment due to cancer and its therapy is a major concern among cancer patients and survivors. Extracellular vesicle (EVs) composition altered by cancer and chemotherapy may affect neurological processes such as neuroplasticity, potentially ...
Yong Qin Koh +9 more
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