Results 1 to 10 of about 230,336 (310)

ASSOCIATION OF MATRIX METALLOPROTEINASES GENE POLYMORPHISM WITH CLINICAL MANIFESTATIONS OF BRONCHIAL ASTHMA IN CHILDREN

Медицинская иммунология, 2018
In the present study, we have examined association between different polymorphic variants of metalloproteinases genes and clinical manifestations of bronchial asthma in children.
A. A. Lebedenko, T. P. Shkurat, E. V. Mashkina, O. E. Semernik, T. K. Dreyzina, E. B. Tyurina   +5 more
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Serum matrix metalloproteinase-2,9 activity, galectin-3 and systemic inflammation in patients with postinfarction heart failure with preserved ejection fraction.

Medičnì Perspektivi, 2018
The available data suggest that heart failure (HF) after myocardial infarction (MI) is a very frequent event. Recent meta-analysis showed that restrictive mitral filling pattern, the most severe form of diastolic dysfunction, was presented in ...
O. Kuryata, A. Zabida, O. Sirenko
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Metalloproteinases and tissue inhibitors of metalloproteinases in exudative pleural effusions [PDF]

European Respiratory Journal, 2005
The aim of this study was to assess the expression of several metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in exudative pleural effusions, and their relationship with inflammatory and fibrinolytic mediators in parapneumonic effusions.The study included 51 parapneumonic effusions (30 empyema or complicated parapneumonic,
D, Iglesias, J, Alegre, C, Alemán, E, Ruíz, T, Soriano, L I, Armadans, R M, Segura, A, Anglés, J, Monasterio, T Fernández, de Sevilla   +9 more
openaire   +2 more sources

Zymography of Metalloproteinases

Current Protocols in Protein Science, 2003
AbstractZymography is an electrophoretic technique enabling visualization of the number and approximate size of peptidases in a sample on the basis of their hydrolysis of a protein substrate within the gel. The technique is particularly useful for analyzing the peptidase composition of complex biological samples because visualization depends directly ...
Troeberg, L, Nagase, H
openaire   +2 more sources

Evaluation of the Inhibition of other Metalloproteinases by Matrix Metalloproteinase Inhibitors [PDF]

Journal of Enzyme Inhibition, 1999
Two series of compounds synthesized as specific matrix metalloproteinase (MMP) inhibitors have been evaluated for their inhibition of non-MMPs. In a series of substituted succinyl hydroxamic acids, some were found to be significant (IC50 < 1 microM) inhibitors of leucine (microsomal) aminopeptidase, neprilysin (3.4.24.11), and thermolysin.
P A, Marcotte, I N, Elmore, Z, Guan, T J, Magoc, D H, Albert, D W, Morgand, M L, Curtin, R B, Garland, Y, Guo, H R, Heyman, J H, Holms, G S, Sheppard, D H, Steinman, C K, Wada, S K, Davidsen   +14 more
openaire   +2 more sources

A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia

eLife
Amyloid β (Aβ) forms aggregates in the Alzheimer’s disease brain and is well known for its pathological roles. Recent studies show that it also regulates neuronal physiology in the healthy brain.
Hyo Jun Kwon, Devi Santhosh, Zhen Huang
doaj   +1 more source

FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE

Вестник анестезиологии и реаниматологии, 2019
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method to treat malignancy and some solid tumors which may be accompanied by life-threatening immune and infectious complications refractory to standard immunosuppressive and ...
O. V. GOLOSHCHAPOV, D. V. CHURAKINA, M. А. KUCHER, R. V. KLEMENTEVA, S. V. SIDORENKO, V. V. GOSTEV, V. Е. KAREV, М. А. SUVOROVA, I. V. SHLYK, А. B. CHUKHLOVIN, L. S. ZUBAROVSKAYA, B. V. AFANASYEV   +11 more
doaj   +1 more source

MMP2 as an independent prognostic stratifier in oral cavity cancers

OncoImmunology, 2020
Background Around 25% of oral cavity squamous cell carcinoma (OCSCC) are not controlled by the standard of care, but there is currently no validated biomarker to identify those patients. Our objective was to determine a robust biomarker for severe OCSCC,
Caroline Hoffmann, Sophie Vacher, Philémon Sirven, Charlotte Lecerf, Lucile Massenet, Aurélie Moreira, Aurore Surun, Anne Schnitzler, Jerzy Klijanienko, Odette Mariani, Emmanuelle Jeannot, Nathalie Badois, Maria Lesnik, Olivier Choussy, Christophe Le Tourneau, Maude Guillot-Delost, Maud Kamal, Ivan Bieche, Vassili Soumelis   +18 more
doaj   +1 more source

Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention

Frontiers in Physiology, 2021
Systemic sclerosis (SSc) is a chronic debilitating idiopathic disorder, characterized by deposition of excessive extracellular matrix (ECM) proteins such as collagen which leads to fibrosis of the skin and other internal organs.
Edwin Leong, Michael Bezuhly, Michael Bezuhly, Jean S. Marshall, Jean S. Marshall   +4 more
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Isolation, characterization, and expression of the Montivipera raddei (Caucasus viper) venom metalloprotease-like protein

Research in Pharmaceutical Sciences
Background and purpose: Snake venom contains numerous proteolytic enzymes, including metalloproteases. This study aimed to isolate, characterize the metalloproteinase from Montivipera raddei venom and insert its cDNA into a host cell genome for ...
Zohreh Jafari, Behnam Sedaghati, Mohammad Kaboli, Bahram Kazemi, Mojgan Bandehpour   +4 more
doaj   +1 more source