Results 41 to 50 of about 182,335 (266)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia

eLife
Amyloid β (Aβ) forms aggregates in the Alzheimer’s disease brain and is well known for its pathological roles. Recent studies show that it also regulates neuronal physiology in the healthy brain.
Hyo Jun Kwon, Devi Santhosh, Zhen Huang
doaj   +1 more source

FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE

Вестник анестезиологии и реаниматологии, 2019
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method to treat malignancy and some solid tumors which may be accompanied by life-threatening immune and infectious complications refractory to standard immunosuppressive and ...
O. V. GOLOSHCHAPOV, D. V. CHURAKINA, M. А. KUCHER, R. V. KLEMENTEVA, S. V. SIDORENKO, V. V. GOSTEV, V. Е. KAREV, М. А. SUVOROVA, I. V. SHLYK, А. B. CHUKHLOVIN, L. S. ZUBAROVSKAYA, B. V. AFANASYEV   +11 more
doaj   +1 more source

MMP2 as an independent prognostic stratifier in oral cavity cancers

OncoImmunology, 2020
Background Around 25% of oral cavity squamous cell carcinoma (OCSCC) are not controlled by the standard of care, but there is currently no validated biomarker to identify those patients. Our objective was to determine a robust biomarker for severe OCSCC,
Caroline Hoffmann, Sophie Vacher, Philémon Sirven, Charlotte Lecerf, Lucile Massenet, Aurélie Moreira, Aurore Surun, Anne Schnitzler, Jerzy Klijanienko, Odette Mariani, Emmanuelle Jeannot, Nathalie Badois, Maria Lesnik, Olivier Choussy, Christophe Le Tourneau, Maude Guillot-Delost, Maud Kamal, Ivan Bieche, Vassili Soumelis   +18 more
doaj   +1 more source

Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention

Frontiers in Physiology, 2021
Systemic sclerosis (SSc) is a chronic debilitating idiopathic disorder, characterized by deposition of excessive extracellular matrix (ECM) proteins such as collagen which leads to fibrosis of the skin and other internal organs.
Edwin Leong, Michael Bezuhly, Michael Bezuhly, Jean S. Marshall, Jean S. Marshall   +4 more
doaj   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Isolation, characterization, and expression of the Montivipera raddei (Caucasus viper) venom metalloprotease-like protein

Research in Pharmaceutical Sciences
Background and purpose: Snake venom contains numerous proteolytic enzymes, including metalloproteases. This study aimed to isolate, characterize the metalloproteinase from Montivipera raddei venom and insert its cDNA into a host cell genome for ...
Zohreh Jafari, Behnam Sedaghati, Mohammad Kaboli, Bahram Kazemi, Mojgan Bandehpour   +4 more
doaj   +1 more source

Metalloproteinases and Wound Healing [PDF]

Advances in Wound Care, 2015
Significance: Matrix metalloproteinases (MMPs) are present in both acute and chronic wounds. They play a pivotal role, with their inhibitors, in regulating extracellular matrix degradation and deposition that is essential for wound reepithelialization.
Matthew P, Caley, Vera L C, Martins, Edel A, O'Toole   +2 more
openaire   +2 more sources