Results 61 to 70 of about 354,418 (364)

The ADAM metalloproteinases

Molecular Aspects of Medicine, 2008
The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane and secreted proteins with important roles in regulating cell phenotype via their effects on cell adhesion, migration, proteolysis and signalling. Though all ADAMs contain metalloproteinase domains, in humans only 13 of the 21 genes in the family encode functional
Edwards, Dylan R., Handsley, Madeleine M., Pennington, Caroline J.   +2 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identification and Structural Characterization of a Novel COL3A1 Gene Duplication in a Family With Vascular Ehlers–Danlos Syndrome

Molecular Genetics & Genomic Medicine
Background Vascular Ehlers–Danlos syndrome (vEDS) is caused by alterations in the COL3A1 gene, typically involving missense variants that replace glycine residues.
Gianmaria Miolo, Piernicola Machin, Marco De Conto, Sara Fortuna, Simona Viglio, Lara Della Puppa, Silvano Geremia, Giuseppe Corona   +7 more
doaj   +1 more source

Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions [PDF]

, 2016
An exact classification of precancerous stages of colorectal polyps might improve therapy and patients´ outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from ...
Churin, Yuri, Gattenlöhner, Stefan, Roderfeld, Martin, Roeb, Elke, Sheridan, Diana, Tschuschner, Annette, Wernicke, Anna-Katharina, Windhorst, Anita   +7 more
core   +1 more source

Metalloproteinases in atherosclerosis [PDF]

European Journal of Pharmacology, 2017
Atherosclerosis underlies most cardiovascular diseases, and is accepted as a primary cause of mortality worldwide. Proteases have been implicated in the development and progression of atherosclerosis, due to their ability to provoke focal destruction of the vascular extracellular matrix.
openaire   +4 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

ASSOCIATION OF MATRIX METALLOPROTEINASES GENE POLYMORPHISM WITH CLINICAL MANIFESTATIONS OF BRONCHIAL ASTHMA IN CHILDREN

Медицинская иммунология, 2018
In the present study, we have examined association between different polymorphic variants of metalloproteinases genes and clinical manifestations of bronchial asthma in children.
A. A. Lebedenko, T. P. Shkurat, E. V. Mashkina, O. E. Semernik, T. K. Dreyzina, E. B. Tyurina   +5 more
doaj   +1 more source

A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease [PDF]

, 2007
Dupuytren’s disease (DD) is a common fibrotic condition of the palmar fascia, leading to deposition of collagen-rich cords and finger contractions. The metzincin superfamily contains key enzymes in the turnover of collagen and other extracellular matrix ...
Adrian J. Chojnowski, Baker, Baragi, Bird, Bisson, Bretz, Brinckerhoff, Brown, Bunker, Clark, Daniels, Drummond, d’Ortho, Graham P. Riley, Hutchinson, Ian M. Clark, Iredale, Jones, Jung, Kashiwagi, Kevorkian, Knauper, Le Goff, Luck, Mikkelsen, Mirastschijski, Moyer, Murphy, Nuttall, Ohuchi, Phillip Johnston, Porter, Porter, Price, Qian, Rayan, Rose K. Davidson, Schaer, Scott, Simon T. Donell, Smith, Tarlton, Tarpila, Thurston, Ulrich, Unemori, Unemori, Unemori, Williams   +48 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Serum matrix metalloproteinase-2,9 activity, galectin-3 and systemic inflammation in patients with postinfarction heart failure with preserved ejection fraction.

Medičnì Perspektivi, 2018
The available data suggest that heart failure (HF) after myocardial infarction (MI) is a very frequent event. Recent meta-analysis showed that restrictive mitral filling pattern, the most severe form of diastolic dysfunction, was presented in ...
O. Kuryata, A. Zabida, O. Sirenko
doaj   +1 more source