Results 81 to 90 of about 354,418 (364)

A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia

eLife
Amyloid β (Aβ) forms aggregates in the Alzheimer’s disease brain and is well known for its pathological roles. Recent studies show that it also regulates neuronal physiology in the healthy brain.
Hyo Jun Kwon, Devi Santhosh, Zhen Huang
doaj   +1 more source

FECAL MICROBIOTA TRANSPLANTATION IN CRITICAL CONDITION PATIENTS IN HEMATOLOGICAL PRACTICE

Вестник анестезиологии и реаниматологии, 2019
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method to treat malignancy and some solid tumors which may be accompanied by life-threatening immune and infectious complications refractory to standard immunosuppressive and ...
O. V. GOLOSHCHAPOV, D. V. CHURAKINA, M. А. KUCHER, R. V. KLEMENTEVA, S. V. SIDORENKO, V. V. GOSTEV, V. Е. KAREV, М. А. SUVOROVA, I. V. SHLYK, А. B. CHUKHLOVIN, L. S. ZUBAROVSKAYA, B. V. AFANASYEV   +11 more
doaj   +1 more source

MMP2 as an independent prognostic stratifier in oral cavity cancers

OncoImmunology, 2020
Background Around 25% of oral cavity squamous cell carcinoma (OCSCC) are not controlled by the standard of care, but there is currently no validated biomarker to identify those patients. Our objective was to determine a robust biomarker for severe OCSCC,
Caroline Hoffmann, Sophie Vacher, Philémon Sirven, Charlotte Lecerf, Lucile Massenet, Aurélie Moreira, Aurore Surun, Anne Schnitzler, Jerzy Klijanienko, Odette Mariani, Emmanuelle Jeannot, Nathalie Badois, Maria Lesnik, Olivier Choussy, Christophe Le Tourneau, Maude Guillot-Delost, Maud Kamal, Ivan Bieche, Vassili Soumelis   +18 more
doaj   +1 more source

Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers [PDF]

, 2003
Objectives: Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-α (TNF-α) and for activating TNF-α-converting enzyme (TACE).
Becker, Bernhard F., Gilles, Stefanie, Sommerhoff, Christian P., Welsch, Ulrich, Zahler, Stefan   +4 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Isolation, characterization, and expression of the Montivipera raddei (Caucasus viper) venom metalloprotease-like protein

Research in Pharmaceutical Sciences
Background and purpose: Snake venom contains numerous proteolytic enzymes, including metalloproteases. This study aimed to isolate, characterize the metalloproteinase from Montivipera raddei venom and insert its cDNA into a host cell genome for ...
Zohreh Jafari, Behnam Sedaghati, Mohammad Kaboli, Bahram Kazemi, Mojgan Bandehpour   +4 more
doaj   +1 more source

TL1A/DR3 axis involvement in the inflammatory cytokine network during pulmonary sarcoidosis [PDF]

, 2015
BACKGROUND: TNF-like ligand 1A (TL1A), a recently recognized member of the TNF superfamily, and its death domain receptor 3 (DR3), firstly identified for their relevant role in T lymphocyte homeostasis, are now well-known mediators of several immune ...
A. Cabrelle, A. Teramo, C Agostini, C Agostini, C Agostini, C Agostini, C Agostini, C Agostini, C. Agostini, F Meylan, F. Calabrese, F. Calzetti, F. Cinetto, G Bamias, G Bamias, G Bamias, G Mautino, G. Semenzato, GW Jones, J Müller-Quernheim, KA Oswald-Richter, KL Wallace, KS Lee, L Li, L Nissinen, M Facco, M Facco, M. A. Cassatella, M. Facco, MA Cassatella, MA Judson, MT Henry, N Kamada, N Kamada, N. Tamassia, R Polverosi, RE Vandenbroucke, S. Carraro, SK Bedoya, TH Schreiber, TS Migone, V. Martini, VY Taraban, X Sun, Y Aiba, YJ Kang   +45 more
core   +1 more source

Metalloproteinases and Wound Healing [PDF]

Advances in Wound Care, 2015
Significance: Matrix metalloproteinases (MMPs) are present in both acute and chronic wounds. They play a pivotal role, with their inhibitors, in regulating extracellular matrix degradation and deposition that is essential for wound reepithelialization.
Matthew P, Caley, Vera L C, Martins, Edel A, O'Toole   +2 more
openaire   +2 more sources

Matrix Metalloproteinases and Glaucoma

Biomolecules, 2022
Matrix metalloproteinases (MMPs) are enzymes that decompose extracellular matrix (ECM) proteins. MMPs are thought to play important roles in cellular processes, such as cell proliferation, differentiation, angiogenesis, migration, apoptosis, and host defense.
Moo Hyun Kim, Su-Ho Lim
openaire   +3 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source