Results 21 to 30 of about 230,336 (310)

A Metalloproteinase Induces an Inflammatory Response in Preadipocytes with the Activation of COX Signalling Pathways and Participation of Endogenous Phospholipases A₂

Biomolecules, 2021
Matrix metalloproteinases (MMPs) are proteolytic enzymes that have been associated with the pathogenesis of inflammatory diseases and obesity. Adipose tissue in turn is an active endocrine organ capable of secreting a range of proinflammatory mediators ...
Priscila Motta Janovits, Elbio Leiguez, Viviane Portas, Catarina Teixeira   +3 more
doaj   +1 more source

In Vitro Preventive Effect and Mechanism of Action of Weissella cibaria CMU against Streptococcus mutans Biofilm Formation and Periodontal Pathogens

Microorganisms, 2023
In this study, we evaluated the in vitro anti-biofilm, antibacterial, and anti-inflammatory activity of Weissella cibaria CMU (CMU), an oral probiotic, against periodontopathogens.
Mi-Sun Kang, Geun-Yeong Park, A-Reum Lee
doaj   +1 more source

Contribution of Matrix Metalloproteinase-9 to Cerebral Edema and Functional Outcome following Experimental Subarachnoid Hemorrhage [PDF]

, 2011
Background: Cerebral edema is an important risk factor for death and poor outcome following subarachnoid hemorrhage (SAH). However, underlying mechanisms are still poorly understood.
Karsten Schöller, Thal, Serge C., Zausinger, Stefan, Schöller, Karsten, Nikolaus Plesnila, Serge C. Thal, Stefan Zausinger, Feiler, Sergej, Plesnila, Nikolaus, Sergej Feiler   +9 more
core   +1 more source

Metalloproteinases in melanoma

European Journal of Cell Biology, 2014
Tumour cell adhesion, motility, proteolytic activities and cell receptors have important roles in cancer invasion. These processes are involved from early development of melanoma within the epidermis, to tumour cell invasion of the underlying tissue until intravasation of lymphatic or blood vessels, and thereafter, dissemination into distant organs ...
Nives, Moro, Cornelia, Mauch, Paola, Zigrino   +2 more
openaire   +2 more sources

N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells] [PDF]

, 2004
Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability to inhibit apoptosis of HSC via matrix ...
Iredale, John P., Julian Waung, Derek Mann, R Christopher Benyon, Collins, Jane, Arthur, Michael J.P., Murphy, Frank, Nagase, Hideaki, Hideaki Nagase, John P Iredale, Mann, Derek, Frank Murphy, Waung, Julian, Jane Collins, Benyon, R. Christopher, Michael JP Arthur   +15 more
core   +1 more source

Restoration of renal TIMP3 levels via genetics and pharmacological approach prevents experimental diabetic nephropathy

Clinical and Translational Medicine, 2021
Background Diabetic nephropathy (DN), one of the major complications of diabetes, is characterized by albuminuria, glomerulosclerosis, and progressive loss of renal function.
Viviana Casagrande, Giulia Iuliani, Stefano Menini, Giuseppe Pugliese, Massimo Federici, Rossella Menghini   +5 more
doaj   +1 more source

Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]

, 2006
Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Helmut Kolb, Krell, Hans-Willi, Kolb, Helmut, Heidinger, Michael, Michael Heidinger, Hans-Willi Krell, Marianne Jochum, Jochum, Marianne, Christian Ries, Ries, Christian   +9 more
core   +1 more source

Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women [PDF]

, 2009
OBJECTIVES: The endopeptidase matrix metalloproteinase-9 (MMP-9) is implicated in atherosclerotic plaque rupture. We investigate prospective associations between MMP-9 and MI or stroke in an older general population cohort, accounting for established and
Lowe, Gordon, Welsh, P, Thomson, A., Jefferis, B. J., Lennon, L., Lowe, G., Ebrahim, S, Carson, Claire, Jefferis, B.J., Welsh, Paul, Rumley, A., Ebrahim, S., Ebrahim, Shah, Jefferis, Barbara J, Lawlor, Debbie, Jefferis, BJ, Welsh, P., Whincup, Peter, Wannamethee, G, Lawlor, D., Lawlor, D, Wannamethee, G., Rumley, Ann, Whincup, P., Whincup, P, Thomson, Andy, Jefferis, Barbara J., Thomson, A, Lennon, Lucy, Wannamethee, Goya, Carson, C., Rumley, A, Lennon, L, Carson, C, Lowe, G   +34 more
core   +1 more source

Matrix Metalloproteinases

Journal of UOEH, 1997
Matrix-degrading enzymes, matrix metalloproteinases, are members of a unique family of Zinc-binding endopeptidases that are responsible for the metabolism of extracellular components in the tissue stroma. Their controlled expression is essential for normal processes such as wound healing and tissue remodeling, including embryogenesis.
Parsons, S. L., Watson, S. A., Brown, P. D., Collins, H. M., Steele, R. J. C.   +4 more
openaire   +6 more sources

Peptide-Based Inhibitors of ADAM and ADAMTS Metalloproteinases

Frontiers in Molecular Biosciences, 2021
ADAM and ADAMTS are two large metalloproteinase families involved in numerous physiological processes, such as shedding of cell-surface protein ectodomains and extra-cellular matrix remodelling.
Stefano Pluda, Stefano Pluda, Ylenia Mazzocato, Alessandro Angelini, Alessandro Angelini   +4 more
doaj   +1 more source