Results 21 to 30 of about 182,335 (266)

Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation

Toxins, 2016
Snake venom metalloproteinases (SVMPs) are abundant in the venoms of vipers and rattlesnakes, playing important roles for the snake adaptation to different environments, and are related to most of the pathological effects of these venoms in human victims.
Ana M. Moura-da-Silva, Michelle T. Almeida, José A. Portes-Junior, Carolina A. Nicolau, Francisco Gomes-Neto, Richard H. Valente   +5 more
doaj   +1 more source

Biological and Pathological Studies of Rosmarinic Acid as an Inhibitor of Hemorrhagic Trimeresurus flavoviridis (habu) Venom

Toxins, 2010
In our previous report, rosmarinic acid (RA) was revealed to be an antidote active compound in Argusia argentea (family: Boraginaceae). The plant is locally used in Okinawa in Japan as an antidote for poisoning from snake venom, Trimeresurus flavoviridis
Masatake Niwa, Yoshiaki Takaya, Tsunemasa Nonogaki, Toshiaki Nikai, Yumiko Komori, Hnin Thanda Aung   +5 more
doaj   +1 more source

Vibrio vulnificus MO6-24/O Lipopolysaccharide Stimulates Superoxide Anion, Thromboxane B2, Matrix Metalloproteinase-9, Cytokine and Chemokine Release by Rat Brain Microglia in Vitro

Marine Drugs, 2014
Although human exposure to Gram-negative Vibrio vulnificus (V. vulnificus) lipopolysaccharide (LPS) has been reported to result in septic shock, its impact on the central nervous system’s innate immunity remains undetermined.
Alejandro M. S. Mayer, Mary L. Hall, Michael Holland, Cristina De Castro, Antonio Molinaro, Monica Aldulescu, Jeffrey Frenkel, Lauren Ottenhoff, David Rowley, Jan Powell   +9 more
doaj   +1 more source

Zymography of Metalloproteinases

Current Protocols in Protein Science, 2003
AbstractZymography is an electrophoretic technique enabling visualization of the number and approximate size of peptidases in a sample on the basis of their hydrolysis of a protein substrate within the gel. The technique is particularly useful for analyzing the peptidase composition of complex biological samples because visualization depends directly ...
Troeberg, L, Nagase, H
openaire   +2 more sources

Evaluation of the Inhibition of other Metalloproteinases by Matrix Metalloproteinase Inhibitors [PDF]

Journal of Enzyme Inhibition, 1999
Two series of compounds synthesized as specific matrix metalloproteinase (MMP) inhibitors have been evaluated for their inhibition of non-MMPs. In a series of substituted succinyl hydroxamic acids, some were found to be significant (IC50 < 1 microM) inhibitors of leucine (microsomal) aminopeptidase, neprilysin (3.4.24.11), and thermolysin.
P A, Marcotte, I N, Elmore, Z, Guan, T J, Magoc, D H, Albert, D W, Morgand, M L, Curtin, R B, Garland, Y, Guo, H R, Heyman, J H, Holms, G S, Sheppard, D H, Steinman, C K, Wada, S K, Davidsen   +14 more
openaire   +2 more sources

Sub-Cellular Localization of Metalloproteinases in Megakaryocytes

Cells, 2018
Metalloproteinases (MMPs) are zinc-dependent endopeptidases that play essential roles as the mediator of matrix degradation and remodeling during organogenesis, wound healing and angiogenesis.
Alessandro Malara, Daniela Ligi, Christian A. Di Buduo, Ferdinando Mannello, Alessandra Balduini   +4 more
doaj   +1 more source

The ADAM metalloproteinases

Molecular Aspects of Medicine, 2008
The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane and secreted proteins with important roles in regulating cell phenotype via their effects on cell adhesion, migration, proteolysis and signalling. Though all ADAMs contain metalloproteinase domains, in humans only 13 of the 21 genes in the family encode functional
Edwards, Dylan R., Handsley, Madeleine M., Pennington, Caroline J.   +2 more
openaire   +3 more sources

Metalloproteinases and tissue inhibitors of metalloproteinases in exudative pleural effusions [PDF]

European Respiratory Journal, 2005
The aim of this study was to assess the expression of several metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in exudative pleural effusions, and their relationship with inflammatory and fibrinolytic mediators in parapneumonic effusions.The study included 51 parapneumonic effusions (30 empyema or complicated parapneumonic,
D, Iglesias, J, Alegre, C, Alemán, E, Ruíz, T, Soriano, L I, Armadans, R M, Segura, A, Anglés, J, Monasterio, T Fernández, de Sevilla   +9 more
openaire   +2 more sources

Elimination of macrophages reduces glutaraldehyde‐fixed porcine heart valve degeneration in mice subdermal model

Pharmacology Research & Perspectives, 2021
Glutaraldehyde‐fixed porcine heart valve (GPHV) calcify and deteriorate over time. The aim of this study was to explore the roles macrophages play in mediating calcification and degeneration of the valve's connective tissue matrix.
Zongtao Liu, Yixuan Wang, Fei Xie, Xing Liu, Fei Li, Nianguo Dong   +5 more
doaj   +1 more source

Topical Exposure to Nemopilema nomurai Venom Triggers Oedematogenic Effects: Enzymatic Contribution and Identification of Venom Metalloproteinase

Toxins, 2021
Scyphozoan envenomation is featured as severe cutaneous damages due to the toxic effects of venom components released by the stinging nematocysts of a scyphozoan.
Yang Yue, Huahua Yu, Rongfeng Li, Pengcheng Li   +3 more
doaj   +1 more source