Results 1 to 10 of about 12,059 (117)

ADAMTS-1, ADAMTS-5 and ADAMTS-13 are considered potential targets in the treatment of frozen shoulder [PDF]

Journal of Orthopaedic Surgery and Research
Background Frozen shoulder (FS) is a condition that causes shoulder pain and restricted movement, primarily due to inflammation, fibrosis, and adhesion of the shoulder joint capsule. It commonly affects individuals aged 30 to 60 years.
Zihao Zhou, Guanhong Chen
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Serum biomarkers reflecting progression of knee osteoarthritis: a stage-based evaluation of TGF-β3, ADAMTS-4, ADAMTS-5, and MMP-13 [PDF]

BMC Musculoskeletal Disorders
Background Knee osteoarthritis (KOA) is a progressive degenerative joint disease characterized by extracellular matrix (ECM) degradation and dysregulated inflammatory signaling.
Omer Esmez, Zubeyde Ercan, Secil Yılmaz, Meryem Sedef Doğru   +3 more
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ADAMTS proteases in cardiovascular physiology and disease [PDF]

Open Biology, 2020
The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family comprises 19 proteases that regulate the structure and function of extracellular proteins in the extracellular matrix and blood.
Salvatore Santamaria, Rens de Groot
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Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy

Molecules, 2022
We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular microenvironment of proliferative diabetic ...
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Eef Allegaert, Mohammad Mairaj Siddiquei, Ajmal Ahmad, Priscilla Gikandi, Gert De Hertogh, Ghislain Opdenakker   +7 more
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Association of ADAMTS proteoglycanases downregulation with IVF-ET outcomes in patients with polycystic ovary syndrome: a systematic review and meta-analysis

Reproductive Biology and Endocrinology, 2022
Background A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) is involved in inflammation and fertility in women with polycystic ovary syndrome (PCOS).
Yanbin Shi, Yang Shi, Guiyuan He, Guang Wang, Hongbo Liu, Xiaoguang Shao   +5 more
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Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

Scientific Reports, 2021
ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA).
Salvatore Santamaria, Doretta Cuffaro, Elisa Nuti, Lidia Ciccone, Tiziano Tuccinardi, Francesca Liva, Felicia D’Andrea, Rens de Groot, Armando Rossello, Josefin Ahnström   +9 more
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The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis

Biomolecules, 2022
Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized by the inflammation of the bone leading to degeneration and loss of cartilage function.
Ting Li, Jie Peng, Qingqing Li, Yuan Shu, Peijun Zhu, Liang Hao   +5 more
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Clinical significance of ADAMTS-13/vWF axis in pregnant women at different trimesters of gestation

Акушерство, гинекология и репродукция, 2023
Introduction. The pandemic of a novel coronavirus infection has demonstrated the importance of assessing the ADAMTS-13/vWF axis in patients with COVID-19, because a decline in this ratio mirrors disease severity.
K. N. Grigoreva, N. R. Gashimova, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, V. I. Tsibizova, N. D. Degtyareva, A. V. Mulenkova, J.-C. Gris, M. V. Kvaratskheliia, E. Grandone, F. E. Yakubova, D. V. Blinov, A. D. Makatsariya   +14 more
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Regulation of ADAMTS Proteases

Frontiers in Molecular Biosciences, 2021
A disintegrin and metalloprotease with thrombospondin type I motifs (ADAMTS) proteases are secreted metalloproteinases that play key roles in the formation, homeostasis and remodeling of the extracellular matrix (ECM).
Keron W. J. Rose, Nandaraj Taye, Stylianos Z. Karoulias, Dirk Hubmacher   +3 more
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ADAMTS-1 in abdominal aortic aneurysm. [PDF]

PLoS ONE, 2017
Extracellular matrix degradation is a hallmark of abdominal aortic aneurysm (AAA). Among proteases that are capable of degrading extracellular matrix are a disintegrin and metalloproteases with thrombospondin motifs (ADAMTS).
Emina Vorkapic, Maggie Folkesson, Kerstin Magnell, Mohammad Bohlooly-Y, Toste Länne, Dick Wågsäter   +5 more
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