Results 41 to 50 of about 15,848 (207)

Molecular analyses of ADAMTS-1, -4, -5, and IL-17 a cytokine relationship in patients with ulcerative colitis

BMC Gastroenterology, 2023
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease that develops due to the impaired immune response in genetically susceptible individuals, and its etiopathogenesis is not fully elucidated.
Tahir Buran, Muhammet Burak Batır, Fethi Sırrı Çam, Elmas Kasap, Fatih Çöllü, Hamide Betül Gerik Çelebi, Mustafa Şahin   +6 more
doaj   +1 more source

ADAMTS proteases and cancer

Matrix Biology, 2015
ADAMTSs (A disintegrin and metalloprotease domains with thrombospondins motifs) are complex extracellular proteases that have been related to both oncogenic and tumor-protective functions. These enzymes can be secreted by cancer and stromal cells and may contribute to modify the tumor microenvironment by multiple mechanisms. Thus, ADAMTSs can cleave or
Cal Miguel, Santiago Jesús, López Otín, Carlos   +1 more
openaire   +3 more sources

Multi-Omics Pan-Cancer Analysis of Procollagen N-Propeptidase Gene Family of ADAMTS as Novel Biomarkers to Associate with Prognosis, Tumor Immune Microenvironment, Signaling Pathways, and Drug Sensitivities

Frontiers in Bioscience-Landmark
Background: The extracellular matrix (ECM) modeling induced by the metalloproteinases is a vital characteristic for tumor progression. Previous studies mainly focus on the functions of two subgroups of metalloproteinases: matrix metalloproteinases (MMPs)
Yuxing Chen, Chaoyu Xiao, Qingxin Fan, Ye Zhang, Qiu Huang, Yunsheng Ou   +5 more
doaj   +1 more source

ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia

Hypertension in Pregnancy, 2018
The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies.
Müberra Namlı Kalem, Ziya Kalem, Tuncay Yüce, Feride Soylemez   +3 more
doaj   +1 more source

The Prognostic Value of ADAMTS-13 and von Willebrand Factor in COVID-19 Patients: Prospective Evaluation by Care Setting

Diagnostics, 2021
Background: Endothelial dysfunction, coupled with inflammation, induces thrombo-inflammation. In COVID-19, this process is believed to be associated with clinical severity.
Giovanni Tiscia, Giovanni Favuzzi, Antonio De Laurenzo, Filomena Cappucci, Lucia Fischetti, Donatella Colaizzo, Elena Chinni, Lucia Florio, Giuseppe Miscio, Angela Pamela Piscitelli, Mario Mastroianno, Elvira Grandone   +11 more
doaj   +1 more source

ADAMTS-4 and ADAMTS-5 are found in the cytoplasm.

, 2016
Western blot containing cytoplasmic and nuclear fractions from MCF-10A (A), MCF-7 (B) and MDA-MB-231 (C) cells, probed for ADAMTS-4, ADAMTS-5, β-actin, histone and GAPDH.
Ruy G. Jaeger (618268), Suély V. Silva (3233223), Maíra A. Lima (3233220), Vanessa M Freitas (3233226), Nathalie Cella (2889740)   +4 more
core   +1 more source

ADAMTS-1 is found predominantly in the nucleus.

, 2016
Immunofluorescence showing ADAMTS-1 localized in the nucleus, ADAMTS-4 and ADAMTS-5 are observed in cytoplasm in MCF-10A (A), MCF-7 (C) and MDA-MB-231 (D) cell lines.
Ruy G. Jaeger (618268), Suély V. Silva (3233223), Maíra A. Lima (3233220), Vanessa M Freitas (3233226), Nathalie Cella (2889740)   +4 more
core   +1 more source

ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis

Scientific Reports, 2017
Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease ...
Eva Bengtsson, Karin Hultman, Pontus Dunér, Giuseppe Asciutto, Peter Almgren, Marju Orho-Melander, Olle Melander, Jan Nilsson, Anna Hultgårdh-Nilsson, Isabel Gonçalves   +9 more
doaj   +1 more source

Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family.

PLoS Computational Biology, 2023
Numerous computational methods based on sequences or structures have been developed for the characterization of protein function, but they are still unsatisfactory to deal with the multiple functions of multi-domain protein families.
Olivier Dennler, François Coste, Samuel Blanquart, Catherine Belleannée, Nathalie Théret   +4 more
doaj   +1 more source

ADAMTS-1 is located in nucleolus.

, 2016
Immunofluorescence shows co-localization of ADAMTS-1 and nucleophosmin in MCF-10A, MCF-7 and MDA-MB-231 cell lines (A). MDA-MB-231 image used for colocalization analysis (B), with the white line used to generate the linescan plot (C).
Ruy G. Jaeger (618268), Suély V. Silva (3233223), Maíra A. Lima (3233220), Vanessa M Freitas (3233226), Nathalie Cella (2889740)   +4 more
core   +1 more source