Results 1 to 10 of about 11,934 (162)
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification [PDF]
Osteoarthritis and Cartilage, 2015 Aggrecanase activity, most notably ADAMTS-5, is implicated in pathogenic cartilage degradation. Selective monoclonal antibodies (mAbs) to both ADAMTS-5 and ADAMTS-4 were generated and in vitro, ex vivo and in vivo systems were utilized to assess target engagement, aggrecanase inhibition and modulation of disease-related endpoints with the intent of ...
Rachel E. Miller
exaly +5 more sources
ADAMTS proteoglycanases downregulation with impaired oocyte quality in PCOS
Archives of Endocrinology and Metabolism, 2021 Objective: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) and ADAMTS-5 normal expression levels are essential for ovulation and subsequent fertilization.
Sepide Gohari taban +7 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2022 Background A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) is involved in inflammation and fertility in women with polycystic ovary syndrome (PCOS).
Yanbin Shi +5 more
doaj +1 more source
Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy
Molecules, 2022 We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular microenvironment of proliferative diabetic ...
Ahmed M. Abu El-Asrar +7 more
doaj +1 more source
BMC Gastroenterology, 2023 Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease that develops due to the impaired immune response in genetically susceptible individuals, and its etiopathogenesis is not fully elucidated.
Tahir Buran +6 more
doaj +1 more source
ADAMTS expression in colorectal cancer. [PDF]
PLoS ONE, 2015 ADAMTSs are a family of secreted proteinases that share the metalloproteinase domain with matrix metalloproteinases (MMPs). By acting on a large panel of extracellular substrates, they control several cell functions such as fusion, adhesion ...
Serafula Filou +8 more
doaj +1 more source
The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. [PDF]
PLoS ONE, 2015 The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5 (aggrecanase-1 and -2) in the cartilage matrix is a critical step in pathology of osteoarthritis (OA).
Yi He +7 more
doaj +1 more source
ADAMTS proteases in cardiovascular physiology and disease [PDF]
Open Biology, 2020 The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family comprises 19 proteases that regulate the structure and function of extracellular proteins in the extracellular matrix and blood.
Salvatore Santamaria, Rens de Groot
doaj +1 more source
Leptin downregulates aggrecan through the p38-ADAMST pathway in human nucleus pulposus cells. [PDF]
PLoS ONE, 2014 The mechanistic basis of obesity-associated intervertebral disc degeneration (IDD) is unclear. Aberrant expression of aggrecan and its degrading enzymes ADAMTS-4 and ADAMTS-5 is implicated in the development of IDD.
Zheng Li +5 more
doaj +1 more source
The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis
Biomolecules, 2022 Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized by the inflammation of the bone leading to degeneration and loss of cartilage function.
Ting Li +5 more
doaj +1 more source