Results 41 to 50 of about 12,658,346 (176)
ADAMTS expression in colorectal cancer. [PDF]
PLoS ONE, 2015 ADAMTSs are a family of secreted proteinases that share the metalloproteinase domain with matrix metalloproteinases (MMPs). By acting on a large panel of extracellular substrates, they control several cell functions such as fusion, adhesion ...
Serafula Filou +8 more
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Journal of Medicinal Chemistry, 2021 There are currently no approved disease-modifying osteoarthritis (OA) drugs (DMOADs). The aggrecanase ADAMTS-5 is key in the degradation of human aggrecan (AGC), a component of cartilage.
F. Brebion +20 more
semanticscholar +1 more source
The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. [PDF]
PLoS ONE, 2015 The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5 (aggrecanase-1 and -2) in the cartilage matrix is a critical step in pathology of osteoarthritis (OA).
Yi He +7 more
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ADAMTS proteases in cardiovascular physiology and disease [PDF]
Open Biology, 2020 The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family comprises 19 proteases that regulate the structure and function of extracellular proteins in the extracellular matrix and blood.
Salvatore Santamaria, Rens de Groot
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Leptin downregulates aggrecan through the p38-ADAMST pathway in human nucleus pulposus cells. [PDF]
PLoS ONE, 2014 The mechanistic basis of obesity-associated intervertebral disc degeneration (IDD) is unclear. Aberrant expression of aggrecan and its degrading enzymes ADAMTS-4 and ADAMTS-5 is implicated in the development of IDD.
Zheng Li +5 more
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The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis
Biomolecules, 2022 Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized by the inflammation of the bone leading to degeneration and loss of cartilage function.
Ting Li +5 more
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PLoS Computational Biology, 2023 Numerous computational methods based on sequences or structures have been developed for the characterization of protein function, but they are still unsatisfactory to deal with the multiple functions of multi-domain protein families.
Olivier Dennler +4 more
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Structure analysis reveals the flexibility of the ADAMTS‐5 active site [PDF]
Protein Science, 2011 AbstractA ((1S,2R)‐2‐hydroxy‐2,3‐dihydro‐1H‐inden‐1‐yl) succinamide derivative (here referred to as Compound 12) shows significant activity toward many matrix metalloproteinases (MMPs), including MMP‐2, MMP‐8, MMP‐9, and MMP‐13. Modeling studies had predicted that this compound would not bind to ADAMTS‐5 (a disintegrin and metalloproteinase with ...
Huey-Sheng, Shieh +11 more
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Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway
Bone & Joint Research, 2021 Aims: Interleukin (IL)-1β is one of the major pathogenic regulators during the pathological development of intervertebral disc degeneration (IDD). However, effective treatment options for IDD are limited.
Zi-Miao Liu +6 more
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Computational and Structural Biotechnology Journal, 2021 Articular cartilage is connective tissue that forms a slippery load-bearing joint surface between bones. With outstanding mechanical properties, it plays an essential role in cushioning impact and protecting the ends of bones.
Yen-Yu Lai, Deng Li, Shu-Wei Chang
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