Results 21 to 30 of about 11,934 (162)

Hemoglobin Stimulates the Expression of Adamts-5 and -9 by Synovial Cells; A Possible Cause of Cartilage Damage after Intra-articular Bleeding [PDF]

Orthopaedic Journal of Sports Medicine, 2017
Objectives: A disintegrin and metalloprotease with thrombospondin motifs (ADAMTS)-5 and -9 play an important pathologic role in matrix degeneration.
Takuya Tajima MD, PhD, Etsuo Chosa M.D., Ph.D., Noboru Taniguchi MD, PhD, Nami YAMAGUCHI MD, PhD   +3 more
doaj   +2 more sources

Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity. [PDF]

J Med Chem, 2023
The dysregulation of proteinase activity is a hallmark of osteoarthritis (OA), a disease characterized by progressive degradation of articular cartilage by catabolic proteinases such as a disintegrin and metalloproteinase with thrombospondin type I motifs-5 (ADAMTS-5).
Fowkes MM, Troeberg L, Brennan PE, Vincent TL, Meldal M, Lim NH.   +5 more
europepmc   +7 more sources

Proteolytic Activities of Human ADAMTS-5 [PDF]

Journal of Biological Chemistry, 2007
Aggrecanases have been characterized as proteinases that cleave the Glu373-Ala374 bond of the aggrecan core protein, and they are multidomain metalloproteinases belonging to the ADAMTS (adamalysin with thrombospondin type 1 motifs) family. The first aggrecanases discovered were ADAMTS-4 (aggrecanase 1) and ADAMTS-5 (aggrecanase 2).
Christi Gendron, Masahide Kashiwagi, Ngee Han Lim, Jan J. Enghild, Ida B. Thøgersen, Clare Hughes, Bruce Caterson, Hideaki Nagase   +7 more
openaire   +4 more sources

Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling. [PDF]

Arterioscler Thromb Vasc Biol, 2018
Objective— Thoracic aortic aneurysm (TAA), a degenerative disease of the aortic wall, is accompanied by changes in the structure and composition of the aortic ECM (extracellular matrix). The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteases has recently been implicated in TAA formation.
Fava M, Barallobre-Barreiro J, Mayr U, Lu R, Didangelos A, Baig F, Lynch M, Catibog N, Joshi A, Barwari T, Yin X, Jahangiri M, Mayr M.   +12 more
europepmc   +5 more sources

Expression and activity of ADAMTS‐5 in synovium [PDF]

European Journal of Biochemistry, 2001
ADAMTS proteinases, belonging to the adamalysin subfamily of metalloproteinases, have been implicated in a variety of cellular events such as morphogenesis, cell migration, angiogenesis, ovulation and extracellular matrix breakdown. Aggrecanase‐1 (ADAMTS‐4) and aggrecanase‐2 (ADAMTS‐5) have been identified in cartilage and are largely responsible for ...
Vankemmelbeke, Mireille N., Maki, Richard A., Buttle, D. J., Liu, Changlu., Burnett, David., Holen, I., Wilson, Anthony G., Ilic, Mirna Zlokovic., Handley, Christopher John., Kelner, Gregory S., Clark, Melody.   +10 more
openaire   +2 more sources

Unlocking ADAMTS-5: <i>In Silico</i> insights into TMJ proteomics and docking dynamics. [PDF]

J Orthod Sci
BACKGROUND: Temporomandibular joint (TMJ) disorder refers to a condition involving dysfunction or pain in the jaw joint and the muscles that control jaw movement. It can affect one or both sides of the jaw and can cause various symptoms, including Jaw pain or tenderness; Difficulty or discomfort when chewing; Clicking, popping,
Divakar A, Kandasamy N, Varghese RM, Jeyachandran S, Thomas LR.   +4 more
europepmc   +4 more sources

Cangxitongbi capsule protects articular cartilage of the knee in rats by regulating ADAMTS-5. [PDF]

Ann Transl Med, 2020
Knee osteoarthritis (KOA) is a disease with a high incidence in elderly patients and traditional Chinese medicine has a significant effect on the treatment of KOA. Cangxitongbi capsule (CXTB) is a traditional Chinese medicine for KOA treatment and has a remarkable curative effect.
Song XY, Xie WP, Zhang P, Zhao M, Bi RX.
europepmc   +4 more sources

In Silico Insights into the Inhibition of ADAMTS-5 by Punicalagin and Ellagic Acid for the Treatment of Osteoarthritis. [PDF]

Int J Mol Sci
ADAMTS-5 (aggrecanase-2) is a major metalloprotease involved in regulating the cartilage extracellular matrix. Due to its role in removing aggrecan in the progression of osteoarthritis (OA), ADAMTS-5 is often regarded as a potential therapeutic target for OA.
Breland AN, Ross MK, Fitzkee NC, Elder SH.   +3 more
europepmc   +3 more sources

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2). [PDF]

Biochem J, 2015
Adamalysin-like metalloproteinases with thrombospondin (TS) motifs (ADAMTS)-5 is the multi-domain metalloproteinase that most potently degrades aggrecan proteoglycan in the cartilage and its activity is implicated in the development of osteoarthritis (OA).
Santamaria S, Yamamoto K, Botkjaer K, Tape C, Dyson MR, McCafferty J, Murphy G, Nagase H.   +7 more
europepmc   +5 more sources

Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family.

PLoS Computational Biology, 2023
Numerous computational methods based on sequences or structures have been developed for the characterization of protein function, but they are still unsatisfactory to deal with the multiple functions of multi-domain protein families.
Olivier Dennler, François Coste, Samuel Blanquart, Catherine Belleannée, Nathalie Théret   +4 more
doaj   +1 more source