Results 1 to 10 of about 279 (133)

Matrilin-2 Is Proteolytically Cleaved by ADAMTS-4 and ADAMTS-5 [PDF]

Molecules, 2014
Matrilin-2 is a widely distributed, oligomeric extracellular matrix protein that forms a filamentous network by binding to a variety of different extracellular matrix proteins.
Zhengke Wang, Junming Luo, Satori Iwamoto, Qian Chen   +3 more
doaj   +3 more sources

ADAMTS-4 as cardiovascular biological marker in atherosclerosis (literature review)

Consilium Medicum
Cardiovascular diseases are a serious problem for medicine, society and economy all over the world. Currently, there is an active search for new biological markers and therapeutic targets in order to develop effective approaches to risk stratification ...
Amina M. Alieva, Elena V. Reznik, Irina E. Bajkova, Natalia V. Teplova, Albina B. Sultangalieva, Elina Z. Etezova, Zhanna L. Rabaeva, Rugaya N. Imanova, Polina Yu. Boeva, Igor G. Nikitin   +9 more
doaj   +2 more sources

The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities [PDF]

Journal of Vascular Research, 2022
Extracellular matrix proteins are regulated by metzincin proteases, like the disintegrin metalloproteinases with thrombospondin motifs (ADAMTS) family members. This review focuses on the emerging role which ADAMTS-4 might play in vascular pathology, which has implications for atherosclerosis and vessel wall abnormalities, as well as for the resulting ...
Rudjer Novak, Stela Hrkac, Grgur Salai, Josko Bilandzic, Luka Mitar, Lovorka Grgurevic   +5 more
  +7 more sources

ADAMTS proteoglycanases downregulation with impaired oocyte quality in PCOS

Archives of Endocrinology and Metabolism, 2021
Objective: A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) and ADAMTS-5 normal expression levels are essential for ovulation and subsequent fertilization.
Sepide Gohari taban, Iraj Amiri, Massoud Saidijam, Sara Soleimani asl, Mahnaz Yavangi, Elham Khanlarzadeh, Nooshin Mohammadpour, Tayebe Artimani   +7 more
doaj   +1 more source

First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator

Diagnostics, 2022
Background: We have previously shown that metzincin protease ADAMTS-4 accompanies renal fibrogenesis, as it appears in the blood of hemodialysis patients.
Ivana Kovacevic Vojtusek, Mario Laganovic, Marija Burek Kamenaric, Stela Bulimbasic, Stela Hrkac, Grgur Salai, Vanja Ivkovic, Marijana Coric, Rudjer Novak, Lovorka Grgurevic   +9 more
doaj   +1 more source

Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy

Molecules, 2022
We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular microenvironment of proliferative diabetic ...
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Eef Allegaert, Mohammad Mairaj Siddiquei, Ajmal Ahmad, Priscilla Gikandi, Gert De Hertogh, Ghislain Opdenakker   +7 more
doaj   +1 more source

Association of ADAMTS proteoglycanases downregulation with IVF-ET outcomes in patients with polycystic ovary syndrome: a systematic review and meta-analysis

Reproductive Biology and Endocrinology, 2022
Background A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) is involved in inflammation and fertility in women with polycystic ovary syndrome (PCOS).
Yanbin Shi, Yang Shi, Guiyuan He, Guang Wang, Hongbo Liu, Xiaoguang Shao   +5 more
doaj   +1 more source

ADAMTS expression in colorectal cancer. [PDF]

PLoS ONE, 2015
ADAMTSs are a family of secreted proteinases that share the metalloproteinase domain with matrix metalloproteinases (MMPs). By acting on a large panel of extracellular substrates, they control several cell functions such as fusion, adhesion ...
Serafula Filou, Aggeliki Korpetinou, Dora Kyriakopoulou, Dimitrios Bounias, Michael Stavropoulos, Panagiota Ravazoula, Dionysios J Papachristou, Achilleas D Theocharis, Demitrios H Vynios   +8 more
doaj   +1 more source

Molecular analyses of ADAMTS-1, -4, -5, and IL-17 a cytokine relationship in patients with ulcerative colitis

BMC Gastroenterology, 2023
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease that develops due to the impaired immune response in genetically susceptible individuals, and its etiopathogenesis is not fully elucidated.
Tahir Buran, Muhammet Burak Batır, Fethi Sırrı Çam, Elmas Kasap, Fatih Çöllü, Hamide Betül Gerik Çelebi, Mustafa Şahin   +6 more
doaj   +1 more source

The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. [PDF]

PLoS ONE, 2015
The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5 (aggrecanase-1 and -2) in the cartilage matrix is a critical step in pathology of osteoarthritis (OA).
Yi He, Qinlong Zheng, MengMeng Jiang, Shu Sun, Thorbjørn G Christiansen, Moustapha Kassem, Morten A Karsdal, Anne C Bay-Jensen   +7 more
doaj   +1 more source