Results 21 to 30 of about 11,949 (172)

Leptin downregulates aggrecan through the p38-ADAMST pathway in human nucleus pulposus cells. [PDF]

PLoS ONE, 2014
The mechanistic basis of obesity-associated intervertebral disc degeneration (IDD) is unclear. Aberrant expression of aggrecan and its degrading enzymes ADAMTS-4 and ADAMTS-5 is implicated in the development of IDD.
Zheng Li, Xin Yu, Jinqian Liang, William Ka Kei Wu, Jun Yu, Jianxiong Shen   +5 more
doaj   +1 more source

TIMP-3 Inhibition of ADAMTS-4 (Aggrecanase-1) Is Modulated by Interactions between Aggrecan and the C-terminal Domain of ADAMTS-4 [PDF]

Journal of Biological Chemistry, 2007
ADAMTS-4 (aggrecanase-1) is a glutamyl endopeptidase capable of generating catabolic fragments of aggrecan analogous to those released from articular cartilage during degenerative joint diseases such as osteoarthritis. Efficient aggrecanase activity requires the presence of sulfated glycosaminoglycans attached to the aggrecan core protein, implying the
Gareth J, Wayne, Su-Jun, Deng, Augustin, Amour, Satty, Borman, Rosalie, Matico, H Luke, Carter, Gillian, Murphy   +6 more
openaire   +2 more sources

The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis

Biomolecules, 2022
Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized by the inflammation of the bone leading to degeneration and loss of cartilage function.
Ting Li, Jie Peng, Qingqing Li, Yuan Shu, Peijun Zhu, Liang Hao   +5 more
doaj   +1 more source

Development of a fluorogenic ADAMTS-7 substrate

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The extracellular protease ADAMTS-7 has been identified as a potential therapeutic target in atherosclerosis and associated diseases such as coronary artery disease (CAD). However, ADAMTS-7 inhibitors have not been reported so far.
Salvatore Santamaria, Frederic Buemi, Elisa Nuti, Doretta Cuffaro, Elena De Vita, Tiziano Tuccinardi, Armando Rossello, Steven Howell, Shahid Mehmood, Ambrosius P. Snijders, Rens de Groot   +10 more
doaj   +1 more source

Philogenetic Analysis of ADAMTS-4 and ADAMTS-5 Structures

Natural Systems and Resources, 2020
ADAMTS-4 and -5 are aggrecanases that are involved in the development of osteoarthrosis by breaking aggrecan at various binding sites, of which cleavage in the Glu373-Ala374 bond plays the most important role in pathogenesis. Therefore, studying them is an urgent task to this day. Now, the structural features of these enzymes have already been studied,
Anastasia Korchagina, Pavel Krylov
openaire   +1 more source

Altered Proteolytic Activities of ADAMTS-4 Expressed by C-terminal Processing [PDF]

Journal of Biological Chemistry, 2004
ADAMTS-4 (a disintegrin and metalloprotease with thrombospondin motifs) is a multidomain metalloproteinase belonging to the reprolysin family. The enzyme cleaves aggrecan core protein at several sites. Here we report that the non-catalytic ancillary domains of the enzyme play a major role in regulating aggrecanase activity, with the C-terminal spacer ...
Kashiwagi, M., Enghild, J.J.; id_orcid 0000-0001-9292-9172, Gendron, C., Hughes, C., Caterson, B., Itoh, Y., Nagase, H.   +6 more
openaire   +5 more sources

A possible issue of articular cartilage degeneration in acute phase after anterior cruciate ligament reconstruction

Orthopaedic Journal of Sports Medicine, 2021
Objectives: Intra-articular hematoma are caused by articular injury such as ligament rupture or intra-articular fracture and following knee surgery. It has been reported that intra-articular hematoma leads to cartilage degeneration. Exposure of articular
Takuya Tajima MD, PhD, Nami Yamaguchi, Takuji Yokoe, Etsuo Chosa, Yudai Morita MD   +4 more
doaj   +1 more source

Effect of Dexamethasone on Cartilage Degeneration in Rats with Collagen-induced Arthritis

Shiyan dongwu yu bijiao yixue, 2022
ObjectiveTo establish a rat model of collagen-induced arthritis (CIA), a rat model of rheumatoid arthritis, and to study the protective effect of dexamethasone (DEX) on cartilage in CIA rats.MethodsThirty Wistar rats were randomly divided into three ...
XU Bingxin, FAN Kaijian, WANG Tingyu, CHEN Huijin   +3 more
doaj   +1 more source

ADAMTS-5: The story so far [PDF]

European Cells & Materials, 2008
The recent discovery of ADAMTS-5 as the major aggrecanase in mouse cartilage came as a surprise. A great deal of research had focused on ADAMTS-4 and much less was known about the regulation, expression and activity of ADAMTS-5. Two years on, it is still
A J Fosang, F M Rogerson, C J East, H Stanton   +3 more
doaj  

Anti‐angiogenic properties of ADAMTS‐4 in vitro

International Journal of Experimental Pathology, 2012
SummaryAngiogenesis is an indispensable mechanism in development and in many pathologies, including cancer, synovitis and aberrant wound healing. Many angiogenic stimulators and inhibitors have been investigated, and some have progressed to the clinic. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a group of multifunctional
Yi-Ping, Hsu, Carolyn A, Staton, Neil, Cross, David J, Buttle   +3 more
openaire   +3 more sources