Results 1 to 10 of about 2,012 (172)
Identifying the human aggrecanase [PDF]
Osteoarthritis and Cartilage, 2010 It is clear that A Disintegrin And Metalloproteinase with ThromboSpondin motif (ADAMTS)-5 is the major aggrecanase in mouse cartilage, however it is not at all clear which enzyme is the major aggrecanase in human cartilage. Identifying the human aggrecanase is difficult because multiple, independent, molecular processes determine the final level of ...
Amanda Fosang
exaly +3 more sources
Biological variation of human aggrecan ARGS neoepitope in synovial fluid and serum in early-stage knee osteoarthritis and after knee injury [PDF]
Osteoarthritis and Cartilage Open, 2022 Objective: To determine biological variation of the aggrecanase-generated aggrecan ARGS neoepitope in serum (sARGS) and synovial fluid (sfARGS) within and between patients with osteoarthritis (OA) or anterior cruciate ligament (ACL) injury.
Staffan Larsson +2 more
doaj +2 more sources
Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor [PDF]
Osteoarthritis and Cartilage, 2011 To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury.
Staffan Larsson +2 more
exaly +3 more sources
Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review
Journal of International Medical Research, 2008 Aggrecanase-mediated aggrecan degradation is a significant event in early-stage osteoarthritis (OA). Aggrecanases belonging to the ‘A Disintegrin And Metalloproteinase with ThromboSpondin motifs’ (ADAMTS) family of proteinases play a significant role in aggrecan depletion in osteoarthritic cartilage. There has been considerable interest in the possible
K, Huang, L D, Wu
exaly +3 more sources
The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis
Biomolecules, 2022 Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized by the inflammation of the bone leading to degeneration and loss of cartilage function.
Ting Li +5 more
doaj +1 more source
CELLULAR AND MOLECULAR ACTIVITY OF A STANDARDIZED SMALL SEA FISH EXTRACT IN AN EXPERIMENTAL MODEL OF PRIMARY HUMAN CARTILAGE CELLS [PDF]
Romanian Journal of Rheumatology, 2018 The inflammatory, degenerative and rheumatic diseases are triggered and evolving at osteoarticular level due to the disruption of functionality of constitutive cells and extracellular microenvironment correlated with systemic responses as synthesis of ...
Emilia Buse +5 more
doaj +1 more source
The cleavage of biglycan by aggrecanases [PDF]
Osteoarthritis and Cartilage, 2006 Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4] and aggrecanase-2 (ADAMTS-5) have been named for their ability to degrade the proteoglycan aggrecan. While this may be the preferred substrate for these enzymes, they are also able to degrade other proteins.
Melching, L.I. +4 more
openaire +2 more sources
Pulmonary Circulation, 2023 Expansion of extracellular matrix occurs in all stages of pulmonary angiopathy associated with pulmonary arterial hypertension (PAH). In systemic arteries, dysregulation and accumulation of the large chondroitin‐sulfate proteoglycan aggrecan is ...
Oscar van derHave +13 more
doaj +1 more source
Matrix Biology Plus, 2021 The RUNX2 transcription factor is a key regulator for the development of cartilage and bone. Global or resting chondrocyte-specific deletion of the Runx2 gene results in failure of chondrocyte hypertrophy, endochondral ossification, and perinatal ...
Harunur Rashid, Haiyan Chen, Amjad Javed
doaj +1 more source
Orthopedic Reviews, 2009 The meniscus plays important roles in proper knee function. It was recently reported that meniscus degeneration was associated with progression of osteoarthritis (OA).
Naoki Ishiguro +3 more
doaj +1 more source