Results 1 to 10 of about 4,064 (126)

ADAMTS4 exacerbates lung cancer progression via regulating c-Myc protein stability and activating MAPK signaling pathway [PDF]

Biology Direct
Background Lung cancer is one of the most frequent cancers and the leading cause of cancer-related deaths worldwide with poor prognosis. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) is crucial in the regulation of the ...
Wei Zhai, Wensheng Yang, Jing Ge, Xuelian Xiao, Kang Wu, Kelin She, Yu Zhou, Yi Kong, Lin Wu, Shiya Luo, Xingxiang Pu   +10 more
doaj   +5 more sources

Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease. [PDF]

Matrix Biol
Osteoarthritis (OA) is a highly prevalent joint disease, affecting millions of people worldwide and characterized by degradation of articular cartilage, subchondral bone remodeling and low-grade inflammation, leading to pain, stiffness and disability.
de Groot R, Folgado PB, Yamamoto K, Martin DR, Koch CD, Debruin D, Blagg S, Minns AF, Bhutada S, Ahnström J, Larkin J, Aspberg A, Önnerfjord P, Apte SS, Santamaria S.   +14 more
europepmc   +5 more sources

ADAMTS4 elicits myeloid-derived immune cell recruitment and liver fibrogenesis in metabolic dysfunction-associated steatotic liver disease [PDF]

Signal Transduction and Targeted Therapy
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) has been implicated in arthritis and lung fibroblast activation; however, its role in liver homeostasis and fibrogenesis remains largely unexplored.
Jeongwoo Park, Taeeung Kim, Wan Seob Shim, Sung Eun Hong, Miso Park, Seungseok Oh, Bo Kyung Koo, Dong Hyeon Lee, Sae Kyung Joo, Taekyeong Yoo, Young Joo Lee, Sung-Chul Lim, Seung-Yong Seo, Kyu Min Kim, Natalia Nieto, Murim Choi, Won Kim, Keon Wook Kang   +17 more
doaj   +2 more sources

A disintegrin and metalloproteinase with thrombospondin motifs 4-targeted molecular magnetic resonance imaging for early detection of extracellular matrix remodeling in a porcine model of abdominal aortic aneurysm [PDF]

Journal of Cardiovascular Magnetic Resonance
: Background: Abdominal aortic aneurysm (AAA) progression is driven by extracellular matrix (ECM) proteolysis and vascular smooth muscle cell loss, processes insufficiently captured by diameter-based surveillance.
Marie-Luise H.H. Ranner-Hafferl, Dilyana B. Mangarova, Jennifer L. Heyl, Jennifer Mein, Jana Möckel, Dirk Schnapauff, Timo A. Auer, Federico Collettini, Lisa C. Adams, David Hingst, Jan O. Kaufmann, Marcus R. Makowski, Uwe Karst, Bernd Hamm, Julia Brangsch, Avan Kader   +15 more
doaj   +2 more sources

ADAMTS4 Reduction Contributes to Extracellular Matrix Deposition and Impaired Myogenesis in the Skeletal Muscle of Cigarette Smoke-Exposed Mice [PDF]

Biomedicines
Background: The extracellular matrix (ECM) plays a critical role in the proper regeneration of skeletal muscle. ECM remodeling has been reported in the skeletal muscle of chronic obstructive pulmonary disease (COPD), while the mechanisms remain poorly ...
Danyang Li, Yuqiang Pei, Long Liang, Zihan Wang, Xiaoyan Gai, Yongchang Sun   +5 more
doaj   +2 more sources

Processing of the Matricellular Protein Hevin in Mouse Brain Is Dependent on ADAMTS4 [PDF]

Journal of Biological Chemistry, 2010
The matricellular SPARC family member hevin (SPARC-like 1/SPARCL-1/SC1/Mast9) contributes to neural development and alters tumor progression in a range of mammalian models. The distribution of hevin in mouse tissues was reexamined with a novel monoclonal antibody that discriminates between hevin and its ortholog SPARC.
Renata Pasqualini, Wadih Arap, Gail Workman   +2 more
exaly   +3 more sources

Effect of intraarticular human umbilical cord mesenchymal stem cells transplantation on cartilage degradation and matrix metalloproteinases in OA rat model [PDF]

BMC Musculoskeletal Disorders
Background Osteoarthritis (OA) is a common cause of disability around the world, but the pathophysiology is still poorly understood. The study sought to investigate the effects of umbilical cord mesenchymal stem cells (UC-MSCs) injection in OA, with a ...
Yanqun Li, Qipeng Han, Shayan Chen, Wenlong Huang, Yanqing Chen, Zhihuang Wu, Fengming Tan, Muyun Liu, Jiangying Zou   +8 more
doaj   +2 more sources

Parallel Networks to Predict TIMP and Protease Cell Activity of Nucleus Pulposus Cells Exposed and Not Exposed to Pro‐Inflammatory Cytokines [PDF]

JOR Spine
Background Intervertebral disc (IVD) degeneration is characterized by a disruption of the balance between anabolic and catabolic cellular processes.
L. Baumgartner, S. Witta, J. Noailly
doaj   +2 more sources

Endothelial BMAL1 decline during aging leads to bone loss by destabilizing extracellular fibrillin-1 [PDF]

The Journal of Clinical Investigation
The occurrence of aging is intricately associated with alterations in circadian rhythms that coincide with stem cell exhaustion. Nonetheless, the extent to which the circadian system governs skeletal aging remains inadequately understood.
Ying Yin, Qingming Tang, Jingxi Yang, Shiqi Gui, Yifan Zhang, Yufeng Shen, Xin Zhou, Shaoling Yu, Guangjin Chen, Jiwei Sun, Zhenshuo Han, Luoying Zhang, Lili Chen   +12 more
doaj   +2 more sources

ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein [PDF]

Biochemical Journal, 2004
Human brain tissue from cerebellum and hippocampus was obtained between 2 h and 24 h post mortem and, after extraction in the presence of proteinase inhibitors, proteoglycans were purified by anion-exchange chromatography. The versican component was characterized by Western analysis with antibodies to the N-terminal peptide (LF99), the N-terminal ...
Westling, Jennifer, Gottschall, Paul E, Thompson, Vivian P, Cockburn, Amber, Perides, George, Zimmermann, Dieter R, Sandy, John D   +6 more
openaire   +4 more sources