Results 21 to 30 of about 4,064 (126)

Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity. [PDF]

JOR Spine
Human intervertebral disc nutrient microenvironment. Changes observed in microenvironmental profile as a result of degeneration outlined on upper vertebral body with ranges of each species as reported in previous studies. Oxygen, glucose, and lactate gradients are profiled across the lower disc in both healthy and degenerated states.
Wilson N, Néill TN, McDonnell J, McDonnell E, Darwish S, Butler JS, Buckley CT.   +6 more
europepmc   +2 more sources

Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression

Journal of Orthopaedic Surgery and Research, 2019
Background Proinflammatory cytokines, which can upregulate the expression of matrix-degrading enzymes in chondrocytes, play important roles in the development of osteoarthritis.
Jin Dai, Sheng Zhou, Qiting Ge, Jinzhong Qin, Jianxin Li, Huangxian Ju, Yi Cao, Minghao Zheng, Chaojun Li, Xiang Gao, Huajian Teng, Qing Jiang   +11 more
doaj   +1 more source

The CNS-specific proteoglycan, brevican, and its ADAMTS4-cleaved fragment show differential serological levels in Alzheimer's disease, other types of dementia and non-demented controls: A cross-sectional study.

PLoS ONE, 2020
Evidence indicate that the brain-specific protein, brevican, is proteolytically cleaved during neurodegeneration, hence positioning fragments of brevican as potential blood biomarkers of neurodegenerative diseases, such as dementia.
Ditte S Jonesco, Morten A Karsdal, Kim Henriksen   +2 more
doaj   +1 more source

Evidence-Based Network Modelling to Simulate Nucleus Pulposus Multicellular Activity in Different Nutritional and Pro-Inflammatory Environments

Frontiers in Bioengineering and Biotechnology, 2021
Initiation of intervertebral disc degeneration is thought to be biologically driven. This reflects a process, where biochemical and mechanical stimuli affect cell activity (CA) that compromise the tissue strength over time. Experimental research enhanced
L. Baumgartner, A. Sadowska, L. Tío, M. A. González Ballester, M. A. González Ballester, K. Wuertz-Kozak, K. Wuertz-Kozak, K. Wuertz-Kozak, J. Noailly   +8 more
doaj   +1 more source

Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin

Open Medicine, 2022
This study examined the potential mechanism of zoledronate on interleukin (IL)-1β-induced temporomandibular joint osteoarthritis (TMJOA) chondrocytes, using IL-1β-induced rabbit immortalized mandibular condylar chondrocytes cultured with zoledronate ...
Xiao Jialing, Li Yali, Cheng Gang, Xu Guochao   +3 more
doaj   +1 more source

Human amniotic membrane modulates Wnt/β-catenin and NF-κβ signaling pathways in articular chondrocytes in vitro

Osteoarthritis and Cartilage Open, 2021
Objective: Inflammation, catabolism, and hypertrophy in chondrocytes play a central role in osteoarthritis (OA). The Wnt/β-catenin and NF-κβ pathways contribute to these degradative processes.
Connie Chung, Michelle Massee, Thomas J. Koob   +2 more
doaj   +1 more source

Periostin interaction with discoidin domain receptor-1 (DDR1) promotes cartilage degeneration.

PLoS ONE, 2020
Osteoarthritis (OA) is characterized by progressive loss of articular cartilage accompanied by the new bone formation and, often, a synovial proliferation that culminates in pain, loss of joint function, and disability.
Tianzhen Han, Paolo Mignatti, Steven B Abramson, Mukundan Attur   +3 more
doaj   +1 more source

Intra-articular injection of placental mesenchymal stromal cells ameliorates pain and cartilage anabolism/catabolism in knee osteoarthritis

Frontiers in Pharmacology, 2022
Background: Knee Osteoarthritis (kOA), the most common joint degenerative disorder, lacks effective therapeutics. Placenta-derived mesenchymal stromal cells (PMSCs) are effective in tissue repairing and generation, which have potential in treating kOA ...
Mengqiang Fan, Jingwen Zhang, Li Zhou, Zuxiang Chen, Ronghua Bao, Longpo Zheng, Peijian Tong, Yuhai Ma, Letian Shan, Letian Shan   +9 more
doaj   +1 more source

Glucocorticoid-induced cell-derived matrix modulates transforming growth factor β2 signaling in human trabecular meshwork cells

Scientific Reports, 2020
Aberrant remodeling of trabecular meshwork (TM) extracellular matrix (ECM) may induce ocular hypertensive phenotypes in human TM (hTM) cells to cause ocular hypertension, via a yet unknown mechanism.
Felix Yemanyi, Janice Vranka, Vijay Krishna Raghunathan   +2 more
doaj   +1 more source

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, EarlyView.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source