Results 11 to 20 of about 4,064 (126)

Integrative genomic and functional characterization of ADAMTS3 reveals its inflammatory regulation via NF-κB and STAT3 pathways in osteosarcoma. [PDF]

J Cell Commun Signal
Abstract Osteosarcoma (OS) is an aggressive bone malignancy characterized by genomic instability and extensive extracellular matrix (ECM) remodeling. Members of the ADAMTS family are matrix‐associated proteases implicated in tumorigenesis; however, their roles in OS remain poorly defined. This study provides a comprehensive genomic, transcriptomic, and
Aymaz EM, Alper M, Sav FN, Aydemir T, Köçkar F.   +4 more
europepmc   +2 more sources

ADAMTS‐4_v1 Is a Splice Variant of ADAMTS‐4 That Is Expressed as a Protein in Human Synovium and Cleaves Aggrecan at the Interglobular Domain [PDF]

Arthritis & Rheumatism, 2013
Objective We previously described a messenger RNA variant of ADAMTS4 ( ADAMTS4_v1 ) in human synovial cell cocultures obtained from patients with osteoarthritis (OA).
Wainwright, Shane Daniel, Bondeson, Jan, Caterson, Bruce, Hughes, Clare Elizabeth   +3 more
openaire   +2 more sources

Danshensu inhibits the IL-1β-induced inflammatory response in chondrocytes and osteoarthritis possibly via suppressing NF-κB signaling pathway

Molecular Medicine, 2021
Purpose Osteoarthritis (OA) is the most common inflammatory disease associated with pain and cartilage destruction. Interleukin (IL)-1β is widely used to induce inflammatory response in OA models.
Zhixian Xu, Tie Ke, Yongfa Zhang, Licheng Guo, Feng Chen, Wubing He   +5 more
doaj   +1 more source

ADAMTS4, 5, 9, and 15 Expressions in the Autopsied Brain of Patients with Alzheimer’s Disease: A Preliminary Immunohistochemistry Study

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Recent studies performed in the central nervous system highlight the pathophysiological relevance of A disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) genes and their protein products.
Sultan Pehlivan, Suleyman Murat Tagil, Mustafa Numan Ural, Murat Serdar Gurses, Nursel Turkmen Inanir, Filiz Eren, Sumeyya Akyol, Bulent Eren, Recep Fedakar, Kadir Demircan   +9 more
doaj   +1 more source

MicroRNA-486 promotes a more catabolic phenotype in chondrocyte-like cells by targeting SIRT6: possible involvement in cartilage degradation in osteoarthritis

Bone & Joint Research, 2021
Aims: Osteoarthritis (OA) is characterized by persistent destruction of articular cartilage. It has been found that microRNAs (miRNAs) are closely related to the occurrence and development of OA.
Jie Yang, Yunping Zhou, Xiaojun Liang, Bingfei Jing, Zandong Zhao   +4 more
doaj   +1 more source

Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.

PLoS ONE, 2014
BackgroundWe hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in ...
Maria Vistnes, Jan Magnus Aronsen, Ida G Lunde, Ivar Sjaastad, Cathrine R Carlson, Geir Christensen   +5 more
doaj   +1 more source

Velvet antler polypeptide partially rescue facet joint osteoarthritis-like phenotype in adult β-catenin conditional activation mice

BMC Complementary and Alternative Medicine, 2019
Background Wnt/β-catenin signaling pathway is closely related to osteoarthritis. In our preliminary study, β-catenin conditional activation (cAct) mice that specifically over-express β-catenin gene in cartilage chondrocyte exhibits osteoarthritis-like ...
Wan-qing Xie, Yong-jian Zhao, Feng Li, Bing Shu, Shu-ru Lin, Li Sun, Yong-jun Wang, Hong-xin Zheng   +7 more
doaj   +1 more source

Use of a bovine genome array to identify new biological pathways for beef marbling in Hanwoo (Korean Cattle)

BMC Genomics, 2010
Background Marbling (intramuscular fat) is a valuable trait that impacts on meat quality and an important factor determining price of beef in the Korean beef market.
Lim Da-jeong, Kim Nam-Kuk, van der Werf Julius, Gondro Cedric, Lee Seung-Hwan, Park Eung-Woo, Oh Sung-Jong, Gibson John P, Thompson John M   +8 more
doaj   +1 more source

Investigation of the biomarkers involved in ectopic ossification: The shared mechanism in ossification of the spinal ligament

Frontiers in Genetics, 2022
Background: Ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF) are multifactor diseases characterized by progressively ectopic ossification in the spinal ligament.
Jiachen Liu, Yunxia Chen, Xiuqi Shan, Huan Wang   +3 more
doaj   +1 more source

Cochlin Deficiency Protects Against Noise-Induced Hearing Loss

Frontiers in Molecular Neuroscience, 2021
Cochlin is the most abundant protein in the inner ear. To study its function in response to noise trauma, we exposed adolescent wild-type (Coch+/+) and cochlin knock-out (Coch–/–) mice to noise (8–16 kHz, 103 dB SPL, 2 h) that causes a permanent ...
Richard Seist, Richard Seist, Richard Seist, Lukas D. Landegger, Lukas D. Landegger, Lukas D. Landegger, Nahid G. Robertson, Sasa Vasilijic, Sasa Vasilijic, Cynthia C. Morton, Cynthia C. Morton, Cynthia C. Morton, Cynthia C. Morton, Konstantina M. Stankovic, Konstantina M. Stankovic, Konstantina M. Stankovic, Konstantina M. Stankovic   +16 more
doaj   +1 more source