Results 1 to 10 of about 4,702 (188)

Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: ADAMTSs (A disintegrin and metalloprotease domains with thrombospondins motifs) are a family of extracellular proteases that have been related to both oncogenic and tumor-suppressive functions.
Jianjun Chen, Yang Luo, Yong Zhou, Shaolan Qin, Yier Qiu, Ran Cui, Minhao Yu, Jun Qin, Ming Zhong   +8 more
doaj   +7 more sources

Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis [PDF]

Erciyes Medical Journal, 2020
Objective: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a large family of proteoglycanase enzymes that show proteolytic activity.
Irmak Icen Taskin, Sevgi Irtegun Kandemir, Kemal Nas, Abdullah Zübeyir Dağlı   +3 more
doaj   +6 more sources

ADAMTS4 exacerbates lung cancer progression via regulating c-Myc protein stability and activating MAPK signaling pathway [PDF]

Biology Direct
Background Lung cancer is one of the most frequent cancers and the leading cause of cancer-related deaths worldwide with poor prognosis. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) is crucial in the regulation of the ...
Wei Zhai, Wensheng Yang, Jing Ge, Xuelian Xiao, Kang Wu, Kelin She, Yu Zhou, Yi Kong, Lin Wu, Shiya Luo, Xingxiang Pu   +10 more
doaj   +3 more sources

Characterization of ADAMTS9 proteoglycanase activity: Comparison with ADAMTS1, ADAMTS4, and ADAMTS5. [PDF]

J Biol Chem
A Disintegrin-like And Metalloprotease domain with Thrombospondin type I motifs (ADAMTS) 9 has essential, non-redundant roles during embryogenesis. Adamts9 null murine embryos die prior to completing gastrulation. Unusually, for a protease, Adamts9 haploinsufficiency results in cardiovascular and ocular anomalies.
Martin DR, Sardelli G, Burkhard T, Fowkes MM, Minns AF, Moschini R, Del Corso A, de Groot R, Apte SS, Santamaria S.   +9 more
europepmc   +7 more sources

ADAMTS4 Reduction Contributes to Extracellular Matrix Deposition and Impaired Myogenesis in the Skeletal Muscle of Cigarette Smoke-Exposed Mice [PDF]

Biomedicines
Background: The extracellular matrix (ECM) plays a critical role in the proper regeneration of skeletal muscle. ECM remodeling has been reported in the skeletal muscle of chronic obstructive pulmonary disease (COPD), while the mechanisms remain poorly ...
Danyang Li, Yuqiang Pei, Long Liang, Zihan Wang, Xiaoyan Gai, Yongchang Sun   +5 more
doaj   +4 more sources

ADAMTS4 elicits myeloid-derived immune cell recruitment and liver fibrogenesis in metabolic dysfunction-associated steatotic liver disease [PDF]

Signal Transduction and Targeted Therapy
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) has been implicated in arthritis and lung fibroblast activation; however, its role in liver homeostasis and fibrogenesis remains largely unexplored.
Jeongwoo Park, Taeeung Kim, Wan Seob Shim, Sung Eun Hong, Miso Park, Seungseok Oh, Bo Kyung Koo, Dong Hyeon Lee, Sae Kyung Joo, Taekyeong Yoo, Young Joo Lee, Sung-Chul Lim, Seung-Yong Seo, Kyu Min Kim, Natalia Nieto, Murim Choi, Won Kim, Keon Wook Kang   +17 more
doaj   +2 more sources

A disintegrin and metalloproteinase with thrombospondin motifs 4-targeted molecular magnetic resonance imaging for early detection of extracellular matrix remodeling in a porcine model of abdominal aortic aneurysm [PDF]

Journal of Cardiovascular Magnetic Resonance
: Background: Abdominal aortic aneurysm (AAA) progression is driven by extracellular matrix (ECM) proteolysis and vascular smooth muscle cell loss, processes insufficiently captured by diameter-based surveillance.
Marie-Luise H.H. Ranner-Hafferl, Dilyana B. Mangarova, Jennifer L. Heyl, Jennifer Mein, Jana Möckel, Dirk Schnapauff, Timo A. Auer, Federico Collettini, Lisa C. Adams, David Hingst, Jan O. Kaufmann, Marcus R. Makowski, Uwe Karst, Bernd Hamm, Julia Brangsch, Avan Kader   +15 more
doaj   +2 more sources

Adamts4 coordinates the transcriptomic profile of primary rat costal chondrocytes. [PDF]

Stem Cells Transl Med
Abstract Chondrocytes play a pivotal role in cartilage tissue engineering. ADAMTS4 gene encodes aggrecanase-1, which is known to affect chondrocyte biology by regulating aggrecan degradation. However, the molecular mechanism by which ADAMTS4 regulates chondrocyte phenotype remains unclear.
Wei Z, Chen Y, Kou W, Zhang Y, Sha W, Guo R, Lei Y, Zhang N, Shi Y, Wang Z.   +9 more
europepmc   +3 more sources

Integrative genomic and functional characterization of ADAMTS3 reveals its inflammatory regulation via NF-κB and STAT3 pathways in osteosarcoma. [PDF]

J Cell Commun Signal
Abstract Osteosarcoma (OS) is an aggressive bone malignancy characterized by genomic instability and extensive extracellular matrix (ECM) remodeling. Members of the ADAMTS family are matrix‐associated proteases implicated in tumorigenesis; however, their roles in OS remain poorly defined. This study provides a comprehensive genomic, transcriptomic, and
Aymaz EM, Alper M, Sav FN, Aydemir T, Köçkar F.   +4 more
europepmc   +2 more sources

Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity. [PDF]

JOR Spine
Human intervertebral disc nutrient microenvironment. Changes observed in microenvironmental profile as a result of degeneration outlined on upper vertebral body with ranges of each species as reported in previous studies. Oxygen, glucose, and lactate gradients are profiled across the lower disc in both healthy and degenerated states.
Wilson N, Néill TN, McDonnell J, McDonnell E, Darwish S, Butler JS, Buckley CT.   +6 more
europepmc   +2 more sources