Results 41 to 50 of about 4,702 (188)

Elevation of MMP1 and ADAMTS5 mRNA expression in glenohumeral synovia of patients with hypercholesterolemia

Journal of Orthopaedic Surgery and Research, 2022
Background Epidemiological studies have reported a positive association between hypercholesterolemia and shoulder disease. Previous studies have focused on the effect of hypercholesterolemia on tendinopathy.
Kyoko Muneshige, Kentaro Uchida, Tomonori Kenmoku, Ryo Tazawa, Mitsufumi Nakawaki, Daisuke Ishii, Gen Inoue, Masashi Takaso   +7 more
doaj   +1 more source

Use of a bovine genome array to identify new biological pathways for beef marbling in Hanwoo (Korean Cattle)

BMC Genomics, 2010
Background Marbling (intramuscular fat) is a valuable trait that impacts on meat quality and an important factor determining price of beef in the Korean beef market.
Lim Da-jeong, Kim Nam-Kuk, van der Werf Julius, Gondro Cedric, Lee Seung-Hwan, Park Eung-Woo, Oh Sung-Jong, Gibson John P, Thompson John M   +8 more
doaj   +1 more source

Adamts4 And Adamts5 Knockout Mice Are Protected From Versican But Not Aggrecan Or Brevican Proteolysis During Spinal Cord Injury [PDF]

, 2014
The chondroitin sulfate proteoglycans (CSPGs) aggrecan, versican, and brevican are large aggregating extracellular matrix molecules that inhibit axonal growth of the mature central nervous system (CNS).
Demircan, Kadir, Ozturk, Gulfer, Yigitoglu, M. Ramazan, Topcu, Vehap, Akyol, Sumeyya, Akyol, Omer, Hasgul, Rukiye, Hirohata, Satoshi, Yonezawa, Tomoko, McCulloch, Daniel R., Ugurcu, Veli, Takigawa, Tomoyuki   +11 more
core   +3 more sources

Processing of the Matricellular Protein Hevin in Mouse Brain Is Dependent on ADAMTS4 [PDF]

Journal of Biological Chemistry, 2010
The matricellular SPARC family member hevin (SPARC-like 1/SPARCL-1/SC1/Mast9) contributes to neural development and alters tumor progression in a range of mammalian models. The distribution of hevin in mouse tissues was reexamined with a novel monoclonal antibody that discriminates between hevin and its ortholog SPARC.
Matt S, Weaver, Gail, Workman, Marina, Cardo-Vila, Wadih, Arap, Renata, Pasqualini, E Helene, Sage   +5 more
openaire   +2 more sources

Velvet antler polypeptide partially rescue facet joint osteoarthritis-like phenotype in adult β-catenin conditional activation mice

BMC Complementary and Alternative Medicine, 2019
Background Wnt/β-catenin signaling pathway is closely related to osteoarthritis. In our preliminary study, β-catenin conditional activation (cAct) mice that specifically over-express β-catenin gene in cartilage chondrocyte exhibits osteoarthritis-like ...
Wan-qing Xie, Yong-jian Zhao, Feng Li, Bing Shu, Shu-ru Lin, Li Sun, Yong-jun Wang, Hong-xin Zheng   +7 more
doaj   +1 more source

Subchondral Bone Microarchitectural and Mineral Properties and Expression of Key Degradative Proteinases by Chondrocytes in Human Hip Osteoarthritis

Biomedicines, 2021
Background: The purpose of this study was to investigate the relationship between the expression of key degradative enzymes by chondrocytes and the microarchitectural and mineral properties of subchondral bone across different stages of cartilage ...
Yunfei Li, Yulia Liem, Zaitunnatakhin Zamli, Niall Sullivan, Enrico Dall’Ara, Haroon Ahmed, Grace Matilda Sellers, Ashley Blom, Mohammed Sharif   +8 more
doaj   +1 more source

Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal Truncation [PDF]

Journal of Biological Chemistry, 2002
Proteolysis of the hyalectans (aggrecan, versican, brevican) in vivo appears to result from the activity of ADAMTS4 (aggrecanase-1, herein referred to as an hyalectanase). To examine the mode of activation of ADAMTS4, a human chondrosarcoma cell line, JJ012, has been stably transfected with the full-length c-DNA for human ADAMTS4. The cells synthesized
Gui, Gao, Jennifer, Westling, Vivian P, Thompson, Troy D, Howell, Paul E, Gottschall, John D, Sandy   +5 more
openaire   +2 more sources

Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway

Pharmaceutical Biology, 2022
Context Osteoarthritis (OA) is a degenerative disease. Senkyunolide A (SenA) is an important phthalide from Ligusticum chuanxiong Hort (Umbelliferae) with anti-spasmodic and neuroprotective effects.Objective We explored the effect of SenA on IL-1β ...
Minglei Shao, Dongwei Lv, Kai Zhou, Haijun Sun, Zhitao Wang   +4 more
doaj   +1 more source

MicroRNA-486 promotes a more catabolic phenotype in chondrocyte-like cells by targeting SIRT6: possible involvement in cartilage degradation in osteoarthritis

Bone & Joint Research, 2021
Aims: Osteoarthritis (OA) is characterized by persistent destruction of articular cartilage. It has been found that microRNAs (miRNAs) are closely related to the occurrence and development of OA.
Jie Yang, Yunping Zhou, Xiaojun Liang, Bingfei Jing, Zandong Zhao   +4 more
doaj   +1 more source

Single‐nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case‐control study

Cancer Medicine, 2019
Previous studies have shown that single‐nucleotide polymorphisms (SNPs) of a disintegrin and metalloproteinase with thrombospondin type 1 motif 4 (ADAMTS4) may involve in the pathogenesis of some diseases.
Xing‐Zhizi Wang, Wei‐Zhong Tang, Qun‐Ying Su, Jin‐Guang Yao, Xiao‐Ying Huang, Qin‐Qin Long, Xue‐Min Wu, Qiang Xia, Xi‐Dai Long   +8 more
doaj   +1 more source