Results 21 to 30 of about 4,702 (188)

Endothelial BMAL1 decline during aging leads to bone loss by destabilizing extracellular fibrillin-1 [PDF]

The Journal of Clinical Investigation
The occurrence of aging is intricately associated with alterations in circadian rhythms that coincide with stem cell exhaustion. Nonetheless, the extent to which the circadian system governs skeletal aging remains inadequately understood.
Ying Yin, Qingming Tang, Jingxi Yang, Shiqi Gui, Yifan Zhang, Yufeng Shen, Xin Zhou, Shaoling Yu, Guangjin Chen, Jiwei Sun, Zhenshuo Han, Luoying Zhang, Lili Chen   +12 more
doaj   +2 more sources

Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries

Scientific Reports, 2022
Pathological cardiac remodeling as an aftermath of a severe cardiac injury can lead to ventricular dysfunction and subsequent heart failure. Adamts4, a metalloproteinase, and disintegrin with thrombospondin-like motif, involved in the turnover of certain
Riffat Khanam, Arunima Sengupta, Dipankar Mukhopadhyay, Santanu Chakraborty   +3 more
doaj   +1 more source

Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth [PDF]

Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth
Several research groups demonstrated that ‘a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS)’-family proteases play roles in cancer progression. However, the origins and contributions of these proteases are not known. Here, we demonstrate an association between host-produced ADAMTS4 and early-stage tumor growth. Murine
Inagaki, Junko, Asano, Keiichi, Ohtsuki, Takashi, Edamatsu, Midori, Hirohata, Satoshi, Ono, Mitsuaki, Oohashi, Toshitaka, F. Hatipoglu, Omer   +7 more
openaire   +1 more source

Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells

Cells, 2023
Terminal complement complex (TCC) deposition was identified in human degenerated discs. To clarify the role of terminal complement activation in disc degeneration (DD), we investigated respective activating mechanisms and cellular effects in annulus ...
Amelie Kuhn, Jana Riegger, Graciosa Q. Teixeira, Markus Huber-Lang, John D. Lambris, Cornelia Neidlinger-Wilke, Rolf E. Brenner   +6 more
doaj   +1 more source

ADAMTS4-Specific MR Peptide Probe for the Assessment of Atherosclerotic Plaque Burden in a Mouse Model. [PDF]

Invest Radiol
Introduction Atherosclerosis is the underlying cause of multiple cardiovascular pathologies. The present-day clinical imaging modalities do not offer sufficient information on plaque composition or rupture risk.
Mangarova DB, Kaufmann JO, Brangsch J, Kader A, Möckel J, Heyl JL, Verlemann C, Adams LC, Ludwig A, Reimann C, Poller WC, Niehaus P, Karst U, Taupitz M, Hamm B, Weller MG, Makowski MR.   +16 more
europepmc   +2 more sources

Compressive mechanical stress enhances susceptibility to interleukin-1 by increasing interleukin-1 receptor expression in 3D-cultured ATDC5 cells

BMC Musculoskeletal Disorders, 2021
Background Mechanical overload applied on the articular cartilage may play an important role in the pathogenesis of osteoarthritis. However, the mechanism of chondrocyte mechanotransduction is not fully understood. The purpose of this study was to assess
Yuki Takeda, Yasuo Niki, Yusuke Fukuhara, Yoshitsugu Fukuda, Kazuhiko Udagawa, Masayuki Shimoda, Toshiyuki Kikuchi, Shu Kobayashi, Kengo Harato, Takeshi Miyamoto, Morio Matsumoto, Masaya Nakamura   +11 more
doaj   +1 more source

CAP-LAMP2b-Modified Stem Cells' Extracellular Vesicles Hybrid with CRISPR-Cas9 Targeting ADAMTS4 to Reverse IL-1β-Induced Aggrecan Loss in Chondrocytes. [PDF]

Int J Mol Sci
Extracellular vesicles (EVs) from mesenchymal stem cells hold therapeutic promise for inflammatory and degenerative diseases; however, limited delivery and targeting capabilities hinder their clinical use.
Wu KC, Chang YH, Chiang RY, Ding DC.
europepmc   +2 more sources

Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus cells: A new therapeutic approach for intervertebral disc disorders. [PDF]

PLoS ONE, 2017
Inhibition of intervertebral disc (IVD) degeneration, which is often accompanied by painful inflammatory and immunopathological processes, is challenging.
Demissew Shenegelegn Mern, Anja Tschugg, Sebastian Hartmann, Claudius Thomé   +3 more
doaj   +1 more source

Expression of ADAMTS4 in Ewing's sarcoma

International Journal of Oncology, 2010
Ewing's sarcoma (EWS) is a malignant bone tumor that frequently occurs in teenagers. Genetic mutations which cause EWS have been investigated, and the most frequent one proved to be a fusion gene between EWS gene of chromosome 22 and the FLI1 gene of chromosome 11.
K, Minobe, R, Ono, A, Matsumine, F, Shibata-Minoshima, K, Izawa, T, Oki, J, Kitaura, T, Iino, J, Takita, S, Iwamoto, H, Hori, Y, Komada, A, Uchida, Y, Hayashi, T, Kitamura, T, Nosaka   +15 more
openaire   +3 more sources

Interrelationship of Osteopontin, MMP-9 and ADAMTS4 in Patients With Osteoarthritis Undergoing Total Joint Arthroplasty

Clinical and Applied Thrombosis/Hemostasis, 2020
Osteoarthritis (OA) is a degenerative joint disease characterized by loss of articular cartilage, inflammation and pain, which sometimes necessitates total joint arthroplasty (TJA).
Hannah Slovacek BS, Rajan Khanna BS, Pavel Poredos MD, Mateja Jezovnik MD, Debra Hoppensteadt PhD, Jawed Fareed PhD, William Hopkinson MD   +6 more
doaj   +1 more source