ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition [PDF]
Communications BiologyHyalectan cleavage may play an important role in extracellular matrix remodeling. However, the proteolytic enzyme responsible for hyalectan degradation for fetal membrane rupture at parturition remains unknown. Here, we reveal that versican (VCAN) is the
Meng-Die Li +9 more
doaj +4 more sources
Promoter methylation status of the TIMP2 and ADAMTS4 genes and patellar tendinopathy [PDF]
Journal of Science and Medicine in Sport, 2018 Patellar tendinopathy (PT) is a debilitating and prevalent condition that tends to affect those who are physically active or engaged in jumping sports. Although tendinopathies are known to have a genetic basis, the role of DNA methylation as an epigenetic factor and risk determinant for human PT has never been described.
El Khoury, Louis Y +3 more
openaire +4 more sources
ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries [PDF]
Nature Communications, 2022 New biomarkers are required to improve the assessment of aortic wall integrity and risk of rupture. Here the authors report the development of an imaging probe for ADAMTS4, which they test in an abdominal aortic aneurysm mouse model and show in vivo ...
Jan O. Kaufmann +17 more
doaj +6 more sources
Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease [PDF]
Matrix BiologyOsteoarthritis (OA) is a highly prevalent joint disease, affecting millions of people worldwide and characterized by degradation of articular cartilage, subchondral bone remodeling and low-grade inflammation, leading to pain, stiffness and disability ...
Christopher Koch +2 more
exaly +8 more sources
Human osteoarthritis synovium contains an alternatively spliced transcript of ADAMTS4 [PDF]
Osteoarthritis and Cartilage, 2012 Purpose: The characterization of an alternatively spliced transcript of the ADAMTS4 aggrecanase. Methods: In human OA synovial cell cultures, RT-PCR was performed using oligonucleotide primers designed to amplify across the exon 8/9 region of human ADAMTS4.
Wainwright, S. +3 more
core +4 more sources
Exuberant fibroblast activity compromises lung function via ADAMTS4 [PDF]
Nature, 2020 Severe respiratory infections can result in acute respiratory distress syndrome (ARDS)1. There are no effective pharmacological therapies that have been shown to improve outcomes for patients with ARDS. Although the host inflammatory response limits spread of and eventually clears the pathogen, immunopathology is a major contributor to tissue damage ...
David F. Boyd +65 more
core +7 more sources
Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth. [PDF]
Acta medica Okayama, 2018 Several research groups demonstrated that 'a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS)'-family proteases play roles in cancer progression. However, the origins and contributions of these proteases are not known. Here, we demonstrate an association between host-produced ADAMTS4 and early-stage tumor growth. Murine
Asano, Keiichi +7 more
openaire +5 more sources
Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding. [PDF]
PLoS ONE, 2014 BackgroundWe hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in ...
Maria Vistnes +5 more
doaj +3 more sources
Parallel Networks to Predict TIMP and Protease Cell Activity of Nucleus Pulposus Cells Exposed and Not Exposed to Pro‐Inflammatory Cytokines [PDF]
JOR SpineBackground Intervertebral disc (IVD) degeneration is characterized by a disruption of the balance between anabolic and catabolic cellular processes.
L. Baumgartner, S. Witta, J. Noailly
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Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population [PDF]
Genetics and Molecular Research, 2016 Considering the functions of aggrecanase-1 (ADAMTS4) and -2 (ADAMTS5), which are thought to be the two major enzymes responsible for the destruction of aggrecans in arthritic diseases, we investigated whether important polymorphisms in the ADAMTS4 and ADAMTS5 genes affect osteoarthritis (OA) susceptibility. Our study took place in Mugla, Turkey. Ninety-
Canbek, Umut +5 more
openaire +4 more sources