Results 31 to 40 of about 4,702 (188)
Knockdown of ADAMTS4 by scAAV6 mediated shRNA. [PDF]
, 2017 1 x 105 NP cells were transduced with 5000 vg/c of recombinant scAAV6 vectors AAV6-Ctrl or AAV6-ADAMTS4. On day 3 of post-transduction monolayer transduced and non-transduced NP cells were transferred to scaffold and harvested on day 8, 16, 24, 32 and 48.
Claudius Thomé (488641) +3 more
core +1 more source
Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes. [PDF]
PLoS ONE, 2017 Lumbar disc degeneration (LDD) is genetically determined and severity of LDD is associated with Modic changes. Aggrecan is a major proteoglycan in the intervertebral disc and end plate. Progressive reduction of aggrecan is a main feature of LDD and Modic
Romain Shanil Perera +5 more
doaj +1 more source
Specific impact AAV6-ADAMTS4 on the levels of ADAMTS4 and aggrecan. [PDF]
, 2017 To examine whether AAV6-ADAMTS4 induces unspecific changes in the expression levels of catabolic, inflammatory and matrix proteins in degenerative NP cells, the expression levels of ADAMTS5, IL-1β, TNF-α and collagen II were examined by using ELISA.
Claudius Thomé (488641) +3 more
core +1 more source
Psychiatry and Clinical Psychopharmacology, 2021 Objective: Recent studies performed in the central nervous system highlight the pathophysiological relevance of A disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) genes and their protein products.
Sultan Pehlivan +9 more
doaj +1 more source
A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes [PDF]
, 2015 OBJECTIVE: Coronary artery disease is characterized by atherosclerosis in the vessel wall. Recently, it has been thought that increasing LDL-binding capacity of subendothelial proteoglycan fragments that are formed by protease activity can be responsible
Bayturan Ö. +6 more
core +5 more sources
Antioxidative behavior of a2-macroglobulin in intervertebral disc degeneration [PDF]
Journal of Medical Biochemistry, 2023 Background: To clarify if a2-macroglobulin (a2M) has an antioxidative effect during the progression of the intervertebral disc degeneration (IVDD). Methods: The content of a2M and reactive oxygen species (ROS) were measured to compare mildly and severely
Chen Yuhong, Wei Huaixiang, Xu Feng
doaj
Relationship between ADAMTS4 and carotid atherosclerotic plaque vulnerability in humans [PDF]
Journal of Vascular Surgery, 2018 Rupture of atherosclerotic plaques and the resulting thrombosis are vital causes of clinical ischemic events. Recent studies have shown that ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4) is a pathogenic factor of plaque vulnerability in mice.
Honglin, Dong +7 more
openaire +2 more sources
Enhancement of aggrecan induced by scAAV6 mediated knockdown of ADAMTS4. [PDF]
, 2017 Viral dose of 5000 vg/c from recombinant scAAV6 vectors AAV6-Ctrl or AAV6-ADAMTS4 were used for transduction of 1 x 105 NP cells. On day 3 of post-transduction, treated and untreated NP cells were transferred to scaffold and harvested on day 8, 16, 24 ...
Claudius Thomé (488641) +3 more
core +1 more source
Regulation of ADAMTS Proteases
Frontiers in Molecular Biosciences, 2021 A disintegrin and metalloprotease with thrombospondin type I motifs (ADAMTS) proteases are secreted metalloproteinases that play key roles in the formation, homeostasis and remodeling of the extracellular matrix (ECM).
Keron W. J. Rose +3 more
doaj +1 more source
Cell Death–associated ADAMTS4 and Versican Degradation in Vascular Tissue [PDF]
Journal of Histochemistry & Cytochemistry, 2009 High blood flow through baboon polytetrafluorethylene aorto-iliac grafts increases neointimal vascular smooth muscle cell (SMC) death, neointimal atrophy, and cleavage of versican to generate the DPEAAE neoepitope, a marker of ADAMTS-mediated proteolysis.
Richard D, Kenagy +3 more
openaire +2 more sources