Results 51 to 60 of about 4,702 (188)

Danshensu inhibits the IL-1β-induced inflammatory response in chondrocytes and osteoarthritis possibly via suppressing NF-κB signaling pathway

Molecular Medicine, 2021
Purpose Osteoarthritis (OA) is the most common inflammatory disease associated with pain and cartilage destruction. Interleukin (IL)-1β is widely used to induce inflammatory response in OA models.
Zhixian Xu, Tie Ke, Yongfa Zhang, Licheng Guo, Feng Chen, Wubing He   +5 more
doaj   +1 more source

Understanding the expression of oligodendrocyte specific ADAMTS4 following a spinal cord injury and a potential modulator of its expression [PDF]

, 2022
The average annual incidence of spinal cord injury (SCI) in New Zealand is 22 cases per million people. These patients have impairments to the anatomy and functioning of their cords that result in abolished transmission of sensory, motor, and autonomic ...
Sheehan, Jerram
core  

ADAMTS4 is a serum biomarker for pulmonary arterial hypertension associated with congenital heart disease

Frontiers in Medicine
ObjectivesPulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) is a cardiopulmonary disorder characterized by pathological pulmonary vascular remodeling and perivascular inflammatory cell infiltration. ADAMTS4 is a secreted,
Genfa Xiao, Genfa Xiao, Yuanrong Chen, Yuanrong Chen, Ying Meng, Ying Meng, Ziliang Wang, Ziliang Wang, Jiumei Cai, Jiumei Cai, Zuofeng Cao, Zuofeng Cao, Shixiu Zeng, Shixiu Zeng, Weihua Liang, Yueling Yu, Haobo Wang, Lijun Nie, Xiaoli Liu, Xiaoli Liu, Yongling Liao, Yongling Liao   +21 more
doaj   +1 more source

Increased mRNA expression of ADAMTS1 and ADAMTS4 in peripheral blood mononuclear cells of psoriasis patients developed psoriatic arthritis [PDF]

, 2023
Background and purpose: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis (PsO) affecting both skin and joint. ADAMTS (A disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats) is a large family of
An, Isa, Irtegun-kandemir, Sevgi, Pektanc-sengul, Gulsum, Nas, Kemal, Tekin, Mehmet ali, Cevik, Remzi   +5 more
core   +1 more source

Concerted actions by MMPs, ADAMTS and serine proteases during remodeling of the cartilage callus into bone during osseointegration of hip implants

Bone Reports, 2020
Introduction: Although the number of patients undergoing total hip arthroplasty is constantly on the rise, we only have limited knowledge of the molecular mechanisms necessary for successful osseointegration of implants or the reasons why some fail ...
Jean Cassuto, Agnetha Folestad, Jan Göthlin, Henrik Malchau, Johan Kärrholm   +4 more
doaj   +1 more source

Injectable hyperbranched PEG crosslinked hyaluronan hydrogel microparticles containing mir-99a-3p modified subcutaneous ADSCs-derived exosomes was beneficial for long-term treatment of osteoarthritis

Materials Today Bio, 2023
Exosomes (Exos) secreted by adipose-derived stem cells (ADSCs) have shown potential in alleviating osteoarthritis (OA). Previous studies indicated that infrapatellar fat pad (IPFP) derived stem cells (IPFSCs) may be more suitable for the treatment of OA ...
Zhaowei Yin, Chaoren Qin, Shaowei Pan, Chen Shi, Guanfu Wu, Yan Feng, Jing Zhang, Ziyi Yu, Bin Liang, Jianchao Gui   +9 more
doaj   +1 more source

Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes [PDF]

Annals of the Rheumatic Diseases, 2009
Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis, but little is known about the possible mechanisms.To investigate the effects of HA species of different molecular mass, including 800 kDa (HA800) and 2700 kDa (HA2700), on the expression of aggrecanases (ie, ADAMTS species), which play ...
Yatabe, T, Mochizuki, S, Takizawa, M, Chijiiwa, M, Okada, A, Kimura, T, Fujita, Y, Matsumoto, H, Toyama, Y, Okada, Y   +9 more
openaire   +2 more sources

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, EarlyView.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source

ADAMTS4 and 5 immunostaining in vein rings. [PDF]

, 2018
(A) ADAMTS4 immunostaining in pre- and 14 day cultured floating vein rings was quantified (B) for the intima/media and adventitia ...
Richard D. Kenagy (141441), Sébastien Deglise (5801789), Thomas N. Wight (262229), Gianfranco B. Fiore (5801792), Marco Piola (692972), Alban Longchamp (798973), Steve P. Evanko (5801786), Shinsuke Kikuchi (2042554), Jacques-Antoine Haefliger (134116), Monica Soncini (391597), Matthijs S. Ruiter (797985), Michael Sobel (2527447), Maurizio Pesce (213660), Tannin A. Schmidt (733703), Mark W. Majesky (404278)   +14 more
core   +1 more source

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source