Results 21 to 30 of about 2,012 (172)

ADAMTS5 in Osteoarthritis: Biological Functions, Regulatory Network, and Potential Targeting Therapies

Frontiers in Molecular Biosciences, 2021
ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment.
Lejian Jiang, Lejian Jiang, Jiachen Lin, Jiachen Lin, Jiachen Lin, Sen Zhao, Sen Zhao, Sen Zhao, Jiaqian Wu, Yongming Jin, Li Yu, Nan Wu, Nan Wu, Nan Wu, Zhihong Wu, Zhihong Wu, Zhihong Wu, Yue Wang, Yue Wang, Mao Lin, Mao Lin, Mao Lin, Mao Lin   +22 more
doaj   +1 more source

Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments

BMC Research Notes, 2009
Background Progressive loss of articular cartilage is a central hallmark in many joint disease, however, the relative importance of individual proteolytic pathways leading to cartilage erosion is at present unknown.
Sondergaard Bodil-Cecilie, Madsen Suzi H, Karsdal Morten A, Jensen Anne-Christine, Chen Pingping, Wang Bijue, Zheng Qinlong, Qvist Per   +7 more
doaj   +1 more source

Advances in understanding cartilage remodeling [v1; ref status: indexed, http://f1000r.es/5e6]

F1000Research, 2015
Cartilage remodeling is currently among the most popular topics in osteoarthritis research. Remodeling includes removal of the existing cartilage and replacement by neo-cartilage.
Yefu Li, Lin Xu
doaj   +1 more source

Natural Compounds: Potential Therapeutics for the Inhibition of Cartilage Matrix Degradation in Osteoarthritis

Life, 2022
Osteoarthritis (OA) is the most common degenerative joint disease characterized by enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and disability.
Omer S. Ashruf, Mohammad Yunus Ansari
doaj   +1 more source

Patients with rheumatoid arthritis have an altered circulatory aggrecan profile

BMC Musculoskeletal Disorders, 2008
Background Rheumatoid arthritis (RA) is a chronic auto-immune disease with extensive articular cartilage destruction. Aggrecan depletion, mediated by aggrecanases is one of the first signs of early cartilage erosion.
Mueller Andreas, Neumann Thomas, Pedersen Christian, Madsen Suzi H, Sondergaard Bodil C, Hein Gert, Sumer Eren U, Rousseau Jean C, Qvist Per, Delmas Pierre, Karsdal Morten A   +10 more
doaj   +1 more source

Development of a highly sensitive chemiluminescence immunoassay for quantification of aggrecanase-generated ARGS aggrecan fragments in serum

Osteoarthritis and Cartilage Open, 2021
Objective: Cartilage degradation is a hallmark of osteoarthritis (OA). Aggrecan, a major proteoglycan of articular cartilage extracellular matrix (ECM), is degraded by ADAMTS-5 resulting in the release of ARGS-G2 fragments to synovial fluid and ...
Yi He, Kamilla E. Jensen, Anne Sofie Siebuhr, Morten A. Karsdal, Jonathan Larkin, Anne C. Bay-Jensen   +5 more
doaj   +1 more source

Matrilin-2 Is Proteolytically Cleaved by ADAMTS-4 and ADAMTS-5

Molecules, 2014
Matrilin-2 is a widely distributed, oligomeric extracellular matrix protein that forms a filamentous network by binding to a variety of different extracellular matrix proteins.
Zhengke Wang, Junming Luo, Satori Iwamoto, Qian Chen   +3 more
doaj   +1 more source

Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes [PDF]

European Cells & Materials, 2012
This study investigated whether treatment of articular cartilage chondrocytes with a combination of oncostatin M (OSM) and interleukin-1 (IL-1) could induce a degradative phenotype that was mediated through the protein kinase R (PKR) signalling pathway ...
SJ Gilbert, EJ Blain, A Al-Sabah, Y Zhang, VC Duance, DJ Mason   +5 more
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In Vitro Study of Licorice on IL-1β-Induced Chondrocytes and In Silico Approach for Osteoarthritis

Pharmaceuticals, 2021
Osteoarthritis (OA) is a common degenerative joint disorder that affects joint function, mobility, and pain. The release of proinflammatory cytokines stimulates matrix metalloproteinases (MMPs) and aggrecanase production which further induces articular ...
Akhtar Ali, YoungJoon Park, Jeonghoon Lee, Hyo-Jin An, Jong-Sik Jin, Jong-Hyun Lee, Jaeki Chang, Dong-Keun Kim, Bonhyuk Goo, Yeon Cheol Park, Kang-Hyun Leem, Shin Seong, Wonnam Kim   +12 more
doaj   +1 more source

Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells [PDF]

European Cells & Materials, 2012
Aggrecanases from the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family are important therapeutic targets due to their essential role in aggrecan depletion in arthritic diseases.
W Richter, B Moradi, CB Little, J Fischer, S Boeuf, F Graf   +5 more
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