Results 11 to 20 of about 2,012 (172)

Establishment of an ex vivo cartilage damage model by combined collagenase treatment and mechanical loading [PDF]

Arthritis Research & Therapy
Background There is a substantial need for ex vivo cartilage damage models to assess new emerging cartilage repair strategies. Ex vivo cartilage explant models have the advantages of achieving standardized and reproducible experimental conditions while ...
Liru Wen, Sibylle Grad, Laura B. Creemers, Martin J. Stoddart   +3 more
doaj   +2 more sources

Temporomandibular joint degeneration arises spontaneously in STR/ort mice and is prevented by targeted aggrecanase inhibition [PDF]

Osteoarthritis and Cartilage Open
Objective: Temporomandibular joint osteoarthritis (TMJ-OA) is painful and causes masticatory dysfunction, but current treatment is limited to symptom relief due to an incomplete appreciation of aetiology. Herein, we develop morphological and histological
Kazuhiro Ooi, Kazuhiro Yamamoto, Yutaka Kobayashi, Behzad Javaheri, Anders Jensen, Ioannis Kanakis, Takao Sakai, Fadi Jarad, Hiroyuki Nakamura, Andrew A. Pitsillides, Shuichi Kawashiri, George Bou-Gharios   +11 more
doaj   +2 more sources

Comparative Effects of Dexamethasone and ASC Secretome in an Ex Vivo Osteoarthritis Co-Culture Model [PDF]

Biology
Osteoarthritis (OA) is a multifactorial disease characterized by inflammation, extracellular matrix remodeling, and joint degeneration, and it still lacks disease-modifying treatments.
Elena Della Morte, Francesca Cadelano, Andrea Pasquini, Luigi Zagra, Alessandro Baj, Chiara Giannasi, Stefania Niada   +6 more
doaj   +2 more sources

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health [PDF]

The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +2 more sources

Computational Insights into Flavonoids for ADAMTS-5 Exosite Inhibition in Knee Osteoarthritis: Docking, MD Simulations, and Machine Learning-Guided Structure Prediction [PDF]

Molecules
The limited selectivity of most catalytic-site ADAMTS-5 inhibitors and the necessity to preserve aggrecan integrity in early-grade knee osteoarthritis require the development of selective aggrecanase inhibitors.
Mayurakkhi Bhatia, Nithyadevi Duraisamy, Mohammed Cherkaoui   +2 more
doaj   +2 more sources

Targeted K‐Edge Nanoprobes From Praseodymium and Hafnium for Ratiometric Tracking of Dual Biomarkers using Spectral Photon Counting CT [PDF]

Advanced Science
Utilizing metal nanoprobes with unique K‐edge identities to visualize complementary biological activities simultaneously can provide valuable information about complex biological processes. This study describes the design and preparation of an innovative
Nivetha Gunaseelan, Parikshit Moitra, Pranay Saha, Teresa Aditya, Mahdieh Moghiseh, Kevin Jonker, Steven Gieseg, Anthony Butler, Fadia Kamal, Dipanjan Pan   +9 more
doaj   +2 more sources

Time-dependent computational model of post-traumatic osteoarthritis to estimate how mechanoinflammatory mechanisms impact cartilage aggrecan content. [PDF]

PLoS Computational Biology
Degenerative musculoskeletal diseases like osteoarthritis can be initiated by joint injury. Injurious overloading-induced mechanical straining of articular cartilage and subsequent biological responses may trigger cartilage degradation. One early sign of
Atte S A Eskelinen, Joonas P Kosonen, Moustafa Hamada, Amir Esrafilian, Cristina Florea, Alan J Grodzinsky, Petri Tanska, Rami K Korhonen   +7 more
doaj   +2 more sources

Human amniotic membrane modulates Wnt/β-catenin and NF-κβ signaling pathways in articular chondrocytes in vitro

Osteoarthritis and Cartilage Open, 2021
Objective: Inflammation, catabolism, and hypertrophy in chondrocytes play a central role in osteoarthritis (OA). The Wnt/β-catenin and NF-κβ pathways contribute to these degradative processes.
Connie Chung, Michelle Massee, Thomas J. Koob   +2 more
doaj   +1 more source

Borrelia burgdorferi Aggrecanase Activity: More Evidence for Persistent Infection in Lyme Disease.

Frontiers in Cellular and Infection Microbiology, 2013
Lyme disease is the most common tickborne illness in the world today. A recent study describes for the first time an enzyme produced by the spirochetal agent of Lyme disease, Borrelia burgdorferi, that cleaves aggrecan, a proteoglycan found in joints and
Raphael B. Stricker, Lorraine eJohnson
doaj   +1 more source

Micromolding-based encapsulation of mesenchymal stromal cells in alginate for intraarticular injection in osteoarthritis

Materials Today Bio, 2023
Osteoarthritis (OA) is an inflammatory joint disease that affects cartilage, subchondral bone, and joint tissues. Undifferentiated Mesenchymal Stromal Cells are a promising therapeutic option for OA due to their ability to release anti-inflammatory ...
Fabien Nativel, Audrey Smith, Jeremy Boulestreau, Charles Lépine, Julie Baron, Melanie Marquis, Caroline Vignes, Yoan Le Guennec, Joelle Veziers, Julie Lesoeur, François Loll, Boris Halgand, Denis Renard, Jerome Abadie, Benoit Legoff, Frederic Blanchard, Olivier Gauthier, Claire Vinatier, Anne des Rieux, Jerome Guicheux, Catherine Le Visage   +20 more
doaj   +1 more source