Results 1 to 10 of about 5,663 (115)

Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma [PDF]

Drug Design, Development and Therapy, 2015
Chongyi Li,1,2 Yanli Xiong,1 Xueqin Yang,1 Lin’ang Wang,1 Shiheng Zhang,1 Nan Dai,1 Mengxia Li,1 Tao Ren,1 Yuxin Yang,1 Shu-Feng Zhou,3 Lixia Gan,2 Dong Wang11Cancer Center, Daping Hospital and Research Institute of Surgery, 2Department of ...
Li C, Xiong Y, Yang X, Wang L, Zhang S, Dai N, Li M, Ren T, Yang Y, Zhou SF, Gan L, Wang D   +11 more
doaj   +6 more sources

Helicobacter pylori contributes to GC progression, possibly via the MSTRG.10627.1/miR-142-5p/ADAMTS5 pathway [PDF]

Frontiers in Microbiology
BackgroundHelicobacter pylori (H. pylori) is a class I carcinogen that induces gastric cancer (GC). The mechanisms underlying its induction of GC are not fully understood. The role of the MSTRG.10627.1/miR-142-5p/ADAMTS5 pathway induced by H.
Zhipeng Yin, Zhipeng Yin, Jianwei Xiang, Pengbo Guo, Pengbo Guo, Nianli Zhang, Xiaoqian Lv, Xiaoqian Lv, Yu Wang, Yu Wang, Yi Wu, Nianhua Zhang, Nianhua Zhang, Gang Lv, Gang Lv, Yinghui Zhao, Yinghui Zhao   +16 more
doaj   +2 more sources

Transcriptional Induction of ADAMTS5 Protein by Nuclear Factor-κB (NF-κB) Family Member RelA/p65 in Chondrocytes during Osteoarthritis Development [PDF]

Journal of Biological Chemistry, 2013
Here we sought to identify transcription factors that induce ADAMTS5, a crucial proteinase for osteoarthritis development. Exhaustive comparison of the genomic sequences of human, macaque, and mouse ADAMTS5 genes revealed that the proximal 1.4 kb of the 5'-end-flanking regions containing several consensus motifs was highly conserved.
Ung-Il Chung, Makoto Hirata, Taku Saito   +2 more
exaly   +3 more sources

Therapeutic effects of Tetramethylpyrazine on Cartilage in Rat Model of Post-traumatic Osteoarthritis [PDF]

Regenerative Therapy
Background: Post-traumatic Osteoarthritis (PTOA) is a common secondary joint disease characterized by cartilage degradation, subchondral bone remodeling, and synovial inflammation following joint trauma.
Zhengjiao Duan, Hongpan Gao, Panpan Li, Si Tang, BenXiang He   +4 more
doaj   +2 more sources

Evaluating the causal effects of circulating plasma proteins on the risk of malignant neoplasms of bone and articular cartilage [PDF]

Journal of International Medical Research
Background Malignant neoplasms of bone and articular cartilage represent a rare group of highly invasive tumours with a poor prognosis, whose molecular mechanisms remain incompletely understood.
Yun Wang, Ruhao Zhou, Zhuangzhuang Wu, Zhi Lv   +3 more
doaj   +2 more sources

Molecular Pathogenesis of Joint Hypermobility: The Role of Intergenic Interactions [PDF]

Medical Sciences
Background: Joint hypermobility (JH) is an increase in the range of joint movements beyond physiological limits. To date, there is no common understanding of the pathogenesis of this condition.
Karina Akhiiarova, Anton Tyurin, Rita Khusainova   +2 more
doaj   +2 more sources

MEX3B aggravates osteoarthritis progression by post-transcriptionally activating TLR4-NF-κB signaling axis [PDF]

Journal of Orthopaedic Surgery and Research
Background Osteoarthritis (OA) is a chronic degenerative joint disease characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling.
Zeze Fu, Yanfeng Huang, Siqi Zhang, Jian Chen   +3 more
doaj   +2 more sources

Wogonin pretreatment of infrapatellar fat pad mesenchymal stem cell-derived exosomes advances articular cartilage repair in osteoarthritis [PDF]

Bone & Joint Research
Aims: Osteoarthritis (OA) is a chronic joint disorder characterized by progressive cartilage degeneration, inflammation, and subchondral bone remodelling.
Wenzhao Li, Minzhi Mao, Cheng Tao, Kewei Zhu   +3 more
doaj   +2 more sources

MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein [PDF]

Matrix Biology, 2011
Aggrecan degradation in articular cartilage occurs predominantly through proteolysis and has been attributed to the action of members of the matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) families. Both families of enzymes cleave aggrecan at specific sites within the aggrecan core protein. One
Durigova, M, Nagase, H, Mort, J, Roughley, P   +3 more
openaire   +2 more sources

Knockdown of Circ_0037658 Alleviates IL-1β-Induced Osteoarthritis Progression by Serving as a Sponge of miR-665 to Regulate ADAMTS5

Frontiers in Genetics, 2022
Background: Osteoarthritis (OA) is a chronic musculoskeletal degeneration disease which brings great pain to patients and a tremendous burden on the world’s medical resources.
Ningbo Li, Ningbo Li, Yongsheng Wang, Xuejian Wu   +3 more
doaj   +1 more source