Frontiers in Molecular Biosciences, 2021 ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment.
Mao Lin, Li Yu, Sen Zhao
exaly +4 more sources
Knockin expression of human ADAMTS5 impairs cardiovascular development and aggravates cerebral cavernous malformations in mice [PDF]
Disease Models & MechanismsADAMTS5 is an enzyme that cleaves chondroitin sulfate proteoglycans such as versican (VCAN) and aggrecan (ACAN). The Adamts5−/− mouse model exhibits aortic anomalies, and increased expression of Adamts4 and Adamts5 leads to excessive versican degradation
Xi Yang +7 more
doaj +3 more sources
Helicobacter pylori contributes to GC progression, possibly via the MSTRG.10627.1/miR-142-5p/ADAMTS5 pathway [PDF]
Frontiers in MicrobiologyBackgroundHelicobacter pylori (H. pylori) is a class I carcinogen that induces gastric cancer (GC). The mechanisms underlying its induction of GC are not fully understood. The role of the MSTRG.10627.1/miR-142-5p/ADAMTS5 pathway induced by H.
Zhipeng Yin +16 more
doaj +3 more sources
ADAMTS5 Orchestrates Cell Lineage Specific Patterning and Extracellular Matrix Organization During Semilunar Valve Development [PDF]
Journal of Cardiovascular Development and DiseaseAortic valve (AV) disease affects about 5% of the aging population, with AV replacement as the only treatment option. Histopathology indicates that accumulation of extracellular matrix (ECM) proteoglycans correlates with dysfunctional AVs.
Loren E. Dupuis +4 more
doaj +3 more sources
Polymorphic Variants of the ADAMTS5 Gene as New Markers of Joint Hypermobility
Современная ревматология, 2023 Joint hypermobility (JH) is a common phenotype that can be both an independent clinical syndrome and a manifestation of connective tissue diseases. The pathogenesis of JH is not well understood.
K. E. Akhiiarova +3 more
doaj +2 more sources
Transcription factor FOXC2 regulates miR-145/ADAMTS5 axis to inhibit angiogenesis in hepatocellular carcinoma via circular RNA 0002898 [PDF]
BMC CancerCircular RNAs (circRNAs), a novel class of single-stranded, covalently closed non-coding RNA molecules, have been increasingly recognized for their roles in the cellular landscape over the past decade.
Jiangbei Yuan +10 more
semanticscholar +2 more sources
IET Systems BiologyADAMTS5, a member of the ADAMTS family, exhibits crucial biological roles, including protein shedding, proteolysis, and cell migration. Its relevance in breast cancer (BC) was explored through an integrative approach combining high‐throughput analyses ...
Najmeh Tavousi +5 more
doaj +2 more sources
The Role of DHEA, NGF, and ADAMTS5 Pathways in Osteoarthritis and Current Developments
Bagcilar Medical Bulletin, 2023 Degenerative joint disease is a condition that affects joints and is commonly referred to as osteoarthritis (OA). This form of arthritis is most prevalent among women and tends to become more frequent as people age.
Duygu Sarı Ak +5 more
doaj +2 more sources
Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis
Cell Death and Disease, 2022 A Disintegrin and Metalloproteinase with ThromboSpondin motif (ADAMTS) 5 functions as an anti-angiogenic and anti-cancer protein independent of its metalloproteinase activity. Both full-length ADAMTS5 and TS5-p45, the autocatalytically cleaved C-terminal
Dogan Can Kirman +5 more
doaj +2 more sources
Autoimmunity, 2022 Background Osteoarthritis (OA) is a common joint disease characterized by progressive cartilage degradation. Circular RNAs (circRNAs) are involved in the initiation and development of OA.
Zhongxing Liu +6 more
doaj +2 more sources