Results 11 to 20 of about 7,117 (194)
IL-33 induces ADAMTS5 expression and cell migration in glioblastoma multiforme
Medical Oncology, 2022 Glioblastoma multiforme (GBM), characterized by a high rate of proliferation and migration capacity, is an incurable brain tumor in adults. Interleukin-33 (IL-33), a member of the IL-1 cytokine superfamily, and a disintegrin and metalloproteinase with ...
Asuman Sunguroğlu +2 more
exaly +4 more sources
Wwp2 maintains cartilage homeostasis through regulation of Adamts5
Nature Communications, 2019 Wwp2 is an HECT-type E3 ubiquitin ligase abundantly expressed in articular cartilage. Here, the authors show that in mice, loss of Wwp2 leads to upregulated Runx2-Adamts5 signaling in articular cartilage and development of osteoarthritis, and that ...
Sho Mokuda +10 more
doaj +4 more sources
Functional role of ADAMTS5 in adiposity and metabolic health. [PDF]
PLoS ONE, 2018 Previous studies with gene-deficient mice (ADAMTS5-P) revealed that ADAMTS5 (A Disintegrin And Metalloproteinase with Thrombospondin type 1 motifs, member 5) plays a functional role in adiposity and metabolic health.
Dries Bauters +3 more
doaj +4 more sources
In Silico Identification of Contradictory Role of ADAMTS5 in Hepatocellular Carcinoma [PDF]
Technology in Cancer Research & Treatment, 2021 Background: ADAMTS5 has different roles in multiple types of cancers and participates in various molecular mechanisms. However, the prognostic value of ADAMTS5 in patients with hepatocellular carcinoma (HCC) still remains unclear. We carried the study to
Zhipeng Zhu +6 more
doaj +3 more sources
LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway
Bioengineered, 2021 Dysregulation of long non-coding RNAs (lncRNAs) plays a fundamental role in the development and progression of osteoarthritis (OA), but the potential functions of lncRNAs in OA were not fully clarified.
Bo Yang, Hui Long
exaly +2 more sources
International Journal of Molecular Sciences, 2023 Skeletal muscle, as a regenerative organization, plays a vital role in physiological characteristics and homeostasis. However, the regulation mechanism of skeletal muscle regeneration is not entirely clear. miRNAs, as one of the regulatory factors, exert
Zhonglin Tang, Xinyun Li, Yilong Yao
exaly +2 more sources
ADAMTS5 Is a Critical Regulator of Virus-Specific T Cell Immunity. [PDF]
PLoS Biology, 2016 The extracellular matrix (ECM) provides physical scaffolding for cellular constituents and initiates biochemical and biomechanical cues that are required for physiological activity of living tissues.
Meagan McMahon +7 more
doaj +4 more sources
Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling [PDF]
Circulation, 2021 Supplemental Digital Content is available in the text. Background: Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and ...
J. Barallobre-Barreiro +24 more
semanticscholar +6 more sources
Cancer MedicineAt present, colorectal cancer (CRC) ranks as the third most prevalent cancer globally and is the second most common cause of mortality associated with cancer. The expression of A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 (ADAMTS5) is
Xuan Sun +7 more
doaj +2 more sources
Design, synthesis and biological activity of glycoconjugated ADAMTS5 exosite inhibitors: applications in osteoarthritis and ovarian cancer models [PDF]
Scientific ReportsPharmacological inhibition of the extracellular zinc metalloprotease A Disintegrin-like And Metalloprotease domain with Thrombospondin type I motifs 5 (ADAMTS5) has been proposed as a treatment for osteoarthritis (OA), a degenerative disease ...
Doretta Cuffaro +14 more
doaj +2 more sources