Results 21 to 30 of about 7,117 (194)

Silencing of circ_0000205 mitigates interleukin-1β-induced apoptosis and extracellular matrix degradation in chondrocytes via targeting miR-766-3p/ADAMTS5 axis

Innate Immunity, 2022
The aim of this study was to explore the role of hsa_circRNA_0000205 (circ_0000205) in chondrocyte injury in osteoarthritis (OA) and the underlying mechanism.
Guowen Li, Heyuan Luo, Zhiyong Ding, Haofeng Liang, Zhoupeng Lai, Shuzhen Chen, Yuliang Huang   +6 more
doaj   +2 more sources

Knockdown of Circ_0037658 Alleviates IL-1β-Induced Osteoarthritis Progression by Serving as a Sponge of miR-665 to Regulate ADAMTS5

Frontiers in Genetics, 2022
Background: Osteoarthritis (OA) is a chronic musculoskeletal degeneration disease which brings great pain to patients and a tremendous burden on the world’s medical resources.
Ningbo Li, Ningbo Li, Yongsheng Wang, Xuejian Wu   +3 more
doaj   +2 more sources

Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis [PDF]

Brazilian Journal of Medical and Biological Research, 2019
Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed to investigate the effects of ADAMTS5 gene polymorphisms on OA risk in a Chinese population ...
Xindie Zhou, Lifeng Jiang, Yi Zhang, Junjie Zhang, Dong Zhou, Lidong Wu, Yong Huang, Nanwei Xu   +7 more
doaj   +4 more sources

Correction: miR-145-Mediated Tumor Suppression in Bladder Urothelial Carcinoma via Targeting the ADAMTS5/Wnt Signaling Axis [PDF]

Cureus
[This corrects the article DOI: 10.7759/cureus.89796.].
Jiang Wei, Zhang L Feng, Cheny Y Mao, Huang Xi, Fu Ming, Chen Jun   +5 more
semanticscholar   +2 more sources

TMF inhibits extracellular matrix degradation by regulating the C/EBPβ/ADAMTS5 signaling pathway in osteoarthritis

Biomedicine and Pharmacotherapy
Osteoarthritis (OA) is a chronic joint disease, characterized by degenerative destruction of articular cartilage. Chondrocytes, the unique cell type in cartilage, mediate the metabolism of extracellular matrix (ECM), which is mainly constituted by ...
Jianguo Zhou
exaly   +2 more sources

Therapeutic effects of Tetramethylpyrazine on Cartilage in Rat Model of Post-traumatic Osteoarthritis [PDF]

Regenerative Therapy
Background: Post-traumatic Osteoarthritis (PTOA) is a common secondary joint disease characterized by cartilage degradation, subchondral bone remodeling, and synovial inflammation following joint trauma.
Zhengjiao Duan, Hongpan Gao, Panpan Li, Si Tang, BenXiang He   +4 more
doaj   +2 more sources

Evaluating the causal effects of circulating plasma proteins on the risk of malignant neoplasms of bone and articular cartilage [PDF]

Journal of International Medical Research
Background Malignant neoplasms of bone and articular cartilage represent a rare group of highly invasive tumours with a poor prognosis, whose molecular mechanisms remain incompletely understood.
Yun Wang, Ruhao Zhou, Zhuangzhuang Wu, Zhi Lv   +3 more
doaj   +2 more sources

ADAMTS5-specific gapmer release from an albumin biomolecular assembly and cartilage internalization triggered by ultrasound

Drug Delivery
Objective Antisense oligonucleotides (ASOs) have reached the clinic; however, they lack tissue specificity. Albumin is a plasma-abundant macromolecule that has been shown to accumulate in inflamed tissues.
Marwa Elkhashab, Goncalo Barreto, Maxime Fauconnier, Yohann Le Bourlout, Laura B. Creemers, Heikki J. Nieminen, Kenneth A. Howard   +6 more
doaj   +2 more sources

ADAMTS5 as a therapeutic target for osteoarthritis: Mendelian randomisation study [PDF]

Annals of the Rheumatic Diseases, 2022
Osteoarthritis (OA) is a progressive disease for which there is no effective diseasemodifying therapy. It is characterised by articular cartilage degradation with uncontrolled proteolytic extracellular matrix destruction.
S. Zhao, V. Karhunen, A. Morris, D. Gill
semanticscholar   +2 more sources

Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican

Journal of Experimental Medicine, 2020
CCMs arise due to increased MEKK3-KLF2/4 signaling in brain endothelial cells, but the downstream mechanisms of CCM formation remain unclear. Hong et al.
Courtney C Hong, A. Tang, Matthew R. Detter, J. Choi, Rui Wang, Xi Yang, Andrea A. Guerrero, Carl Wittig, N. Hobson, R. Girard, R. Lightle, Thomas Moore, R. Shenkar, S. Polster, Lauren M Goddard, Aileen A. Ren, N. Leu, S. Sterling, Jisheng Yang, Li Li, Mei Chen, Patricia Mericko-Ishizuka, L. Dow, H. Watanabe, M. Schwaninger, W. Min, D. Marchuk, Xiangjian Zheng, I. Awad, M. Kahn   +29 more
semanticscholar   +3 more sources