Results 41 to 50 of about 7,117 (194)

Increased Proteoglycanases in Pulmonary Valves after Birth Correlate with Extracellular Matrix Maturation and Valve Sculpting

Journal of Cardiovascular Development and Disease, 2023
Increased mechanical forces on developing cardiac valves drive formation of the highly organized extracellular matrix (ECM) providing tissue integrity and promoting cell behavior and signaling.
Loren E. Dupuis, Sarah E. Evins, Morgan C. Abell, Morgan E. Blakley, Samuel L. Horkey, Jeremy L. Barth, Christine B. Kern   +6 more
doaj   +1 more source

Eif2s3y alleviated LPS-induced damage to mouse testis and maintained spermatogenesis by negatively regulating Adamts5.

Theriogenology, 2023
Eif2s3y (eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked, Eif2s3y) is an essential gene for spermatogenesis. Early studies have shown that Eif2s3y can promote the proliferation of spermatogonial stem cells (SSCs) and can ...
Yunxiang Li, Wenping Wu, Wenjing Xu, Yuqi Wang, Shicheng Wan, Wenbo Chen, Donghui Yang, Mengfei Zhang, Xiaojie Wu, Xinchun Yang, Xiaomin Du, Congliang Wang, Miao Han, Yuguang Chen, Na Li, J. Hua   +15 more
semanticscholar   +1 more source

Effect of miRNA-218-5p on Proliferation, Migration, Apoptosis and Inflammation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm and Extracellular Matrix Protein

Iranian Journal of Public Health, 2022
Background: To explore the effects of miRNA-218-5p on inflammation and extracellular matrix proteins of vascular smooth muscle cell line in abdominal aortic aneurysm (AAA). Methods: miR-218-5p expression was detected with RT-qPCR.
Min Hu, Hui Qiu, Tao He, Minyu Zhong
doaj   +1 more source

A Transcriptional Enhancer from the Coding Region of ADAMTS5

PLoS ONE, 2008
The revelation that the human genome encodes only approximately 25,000 genes and thus cannot account for phenotypic complexity has been one of the biggest surprises in the post-genomic era. However, accumulating evidence suggests that transcriptional regulation may be in large part responsible for this observed mammalian complexity. Consequently, there
Kristen K B Barthel, Xuedong Liu
openaire   +4 more sources

ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures [PDF]

Osteoarthritis and Cartilage, 2006
Aggrecan degradation by aggrecanases [a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) 1, 4, 5, 8, 9, 15] is considered to initiate much of the cartilage pathology seen in human arthritis, however, the proteinase responsible and its mode of control is unclear.
Stewart, M.C., Fosang, A.J., Bai, Y., Osborn, B., Plaas, A., Sandy, J.D.   +5 more
openaire   +2 more sources

Identification of novel ADAMTS1, ADAMTS4 and ADAMTS5 cleavage sites in versican using a label-free quantitative proteomics approach

Journal of Proteomics, 2021
The chondroitin sulfate proteoglycan versican is important for embryonic development and several human disorders. The versican V1 splice isoform is widely expressed and cleaved by ADAMTS proteases at a well-characterized site, Glu441-Ala442. Since ADAMTS
Daniel R. Martin, Salvatore Santamaria, Christopher Koch, Josefin Ahnström, S. Apte   +4 more
semanticscholar   +1 more source

Expression of anti-angiogenic genes in subcutaneous adipose tissue of the obese individuals with pre-diabetes and type 2 diabetes

Біологічні студії, 2012
Accumulating evidence raises the hypothesis that dysregulation of different intrinsic mechanisms which control most metabolic processes are involved in the development of obesity, metabolic syndrome and type 2 diabetes mellitus, the most profound public ...
O. O. Ratushna, D. O. Minchenko, S. V. Danilovskyi, I. Klimes, O. H. Minchenko   +4 more
doaj   +1 more source

ADAMTS5 deficiency in mice does not affect cardiac function

Cell Biology International, 2019
AbstractThe aggrecanase ADAMTS5 (A Disintegrin and Metalloproteinase with ThromboSpondin type 1 motifs, member 5) and the cleavage of its substrate versican have been implicated in the development of heart valves. Furthermore, ADAMTS5 deficiency was shown to protect against diet‐induced obesity, a known risk factor for cardiovascular disease. Therefore,
Hemmeryckx, Bianca, Carai, Paolo, Lijnen, H. Roger   +2 more
openaire   +6 more sources

Effects of insulin-like growth factor-induced Wharton jelly mesenchymal stem cells toward chondrogenesis in an osteoarthritis model [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): This study aimed to determine the collagen type II (COL2) and SOX9 expression in interleukin growth factor (IGF-1)-induced Wharton’s Jelly mesenchymal stem cells (WJMSCs) and the level of chondrogenic markers in co-culture IGF1-WJMSCs and ...
Wahyu Widowati, Ervi Afifah, Tjandrawati Mozef, Ferry Sandra, Rizal Rizal, Annisa Amalia, Yukko Arinta, Indra Bachtiar, Harry Murti   +8 more
doaj   +1 more source

Loss of MEN1 leads to renal fibrosis and decreases HGF‐Adamts5 pathway activity via an epigenetic mechanism

Clinical and Translational Medicine, 2022
Background Renal fibrosis is a serious condition that results in the development of chronic kidney diseases. The MEN1 gene is an epigenetic regulator that encodes the menin protein and its role in kidney tissue remains unclear.
Bangming Jin, Jiamei Zhu, Yuxia Zhou, Li‐zong Liang, Yunqiao Yang, Lifen Xu, Tuo Zhang, P. Li, T. Pan, B. Guo, Tengxiang Chen, Haiyang Li   +11 more
semanticscholar   +1 more source