Results 31 to 40 of about 7,117 (194)
Molecular Pathogenesis of Joint Hypermobility: The Role of Intergenic Interactions [PDF]
Medical SciencesBackground: Joint hypermobility (JH) is an increase in the range of joint movements beyond physiological limits. To date, there is no common understanding of the pathogenesis of this condition.
Karina Akhiiarova +2 more
doaj +2 more sources
The ADAMTS5 Metzincin Regulates Zebrafish Somite Differentiation [PDF]
International Journal of Molecular Sciences, 2018 The ADAMTS5 metzincin, a secreted zinc-dependent metalloproteinase, modulates the extracellular matrix (ECM) during limb morphogenesis and other developmental processes. Here, the role of ADAMTS5 was investigated by knockdown of zebrafish adamts5 during embryogenesis.
Carolyn Dancevic +7 more
openaire +3 more sources
The Zonal Architecture of the Mandibular Condyle Requires ADAMTS5 [PDF]
Journal of Dental Research, 2018 Temporomandibular joint (TMJ) osteoarthritis (TMJOA) disrupts extracellular matrix (ECM) homeostasis, leading to cartilage degradation. Upregulated a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)–5 leads to cleavage of its substrate aggrecan (Acan) and is considered a hallmark of TMJOA.
A W, Rogers, S E, Cisewski, C B, Kern
openaire +2 more sources
Connexin43 Mediated Delivery of ADAMTS5 Targeting siRNAs from Mesenchymal Stem Cells to Synovial Fibroblasts. [PDF]
PLoS ONE, 2015 Osteoarthritis is a joint-destructive disease that has no effective cure. Human mesenchymal stem cells (hMSCs) could offer therapeutic benefit in the treatment of arthritic diseases by suppressing inflammation and permitting tissue regeneration, but ...
Shuo Liu +3 more
doaj +1 more source
Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5 [PDF]
Journal of Biological Chemistry, 2014 Proteolysis of the Glu(441)-Ala(442) bond in the glycosaminoglycan (GAG) β domain of the versican-V1 variant by a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif (ADAMTS) proteases is required for proper embryo morphogenesis.
Foulcer, Simon J +7 more
openaire +3 more sources
MicroRNA-148a targets ADAMTS5 to inhibit proliferation of endometriosis cells
Pakistan Journal of Pharmaceutical Sciences, 2022 To examine miR-148a expression in the serum of patients with endometriosis (EMS), and to further explore the target of miR-148a in HS832.Tc cells and the effect of miR-148a on the proliferation of Hs832.Tc cells.
Shunzhi He +4 more
doaj +1 more source
Біологічні студії, 2012 The angiogenesis is an important component of tumor growth and tightly associated with hypoxia. The expression level of genes related to regulation of angiogenesis (BAI2, SPARC, TIMP1, TIMP2, TIMP3, TIMP4, THBS1, THBS2, ADAMTS5 and FGF2) in glioma ...
K. I. Kubaichuk +5 more
doaj +1 more source
Molecular Metabolism, 2017 Objective: A potential strategy to treat obesity – and the associated metabolic consequences – is to increase energy expenditure. This could be achieved by stimulating thermogenesis through activation of brown adipose tissue (BAT) and/or the induction of
Dries Bauters +5 more
doaj +1 more source
Journal of Orthopaedic Surgery and Research, 2021 Background Osteoarthritis (OA) is responsible for the impotent disability in old people. Circular RNA (circRNA) has been reported to be related to the development of diseases. The lack of research on the role of circRNA spastic paraplegia 11 (circ-SPG11)
Yongqiang Liu +4 more
doaj +1 more source
Cellular Signalling, 2023 Expression of key transcriptional regulators is altered in chondrocytes in osteoarthritis (OA). This contributes to an increase in production of cartilage-catabolizing enzymes such as MMP13 and ADAMTS5.
Julia G B Primrose +7 more
semanticscholar +1 more source