Results 1 to 10 of about 405 (130)
Matrix Biology Plus, 2023 Cardiac fibrosis is a central pathological feature in several cardiac diseases, but the underlying molecular players are insufficiently understood. The extracellular matrix proteoglycan versican is elevated in heart failure and suggested to be a target ...
Athiramol Sasi, Almira Hasic
exaly +3 more sources
Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation
Frontiers in Immunology, 2020 The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 (TSG-6), and inter alpha trypsin inhibitor (IαI) during inflammation in a number ...
Charles Frevert +2 more
exaly +3 more sources
Respiratory Research, 2023 Abstract Background and aims This study aimed to investigate the expression of plasma versican and plasma exosomal versican in non-small cell lung cancer (NSCLC) and its correlation with clinicopathological features, and to evaluate its diagnostic performance in NSCLC and its predictive function for NSCLC incidence and ...
Wenjing Chang +6 more
openaire +3 more sources
A Role for Versican in the Development of Leiomyosarcoma [PDF]
Journal of Biological Chemistry, 2014 Leiomyosarcoma (LMS) is a mesenchymal cancer that occurs throughout the body. Although LMS is easily recognized histopathologically, the cause of the disease remains unknown. Versican, an extracellular matrix proteoglycan, increases in LMS. Microarray analyses of 80 LMSs and 24 leiomyomas showed a significant elevated expression of versican in human ...
Brian Rubin, Thomas N Wight
exaly +3 more sources
Versican V1 Overexpression Induces a Myofibroblast-Like Phenotype in Cultured Fibroblasts. [PDF]
PLoS ONE, 2015 Versican, a chondroitin sulphate proteoglycan, is one of the key components of the provisional extracellular matrix expressed after injury. The current study evaluated the hypothesis that a versican-rich matrix alters the phenotype of cultured ...
Jon M Carthy +6 more
doaj +1 more source
BMP-2 induces versican and hyaluronan that contribute to post-EMT AV cushion cell migration. [PDF]
PLoS ONE, 2013 Distal outgrowth and maturation of mesenchymalized endocardial cushions are critical morphogenetic events during post-EMT atrioventricular (AV) valvuloseptal morphogenesis.
Kei Inai +4 more
doaj +1 more source
Journal of Family Medicine and Primary Care, 2023 Objective: Versican is a chondroitin sulphate proteoglycan with raised expression at site of inflammation, and uterine fibroids are associated with local inflammation. Hence, this study aimed to estimate serum Versican levels in pre-menopausal women with
Pratima Jasti +3 more
doaj +1 more source
Increased renal versican expression is associated with progression of chronic kidney disease. [PDF]
PLoS ONE, 2012 Novel prognostic markers for progression of kidney disease are needed to distinguish patients who might benefit from a more aggressive nephroprotective therapy.
Michael Rudnicki +12 more
doaj +1 more source
Isolation and Purification of Versican and Analysis of Versican Proteolysis [PDF]
, 2014 Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes with the glycosaminoglycan hyaluronan (HA). As a consequence of HA binding to its receptor CD44 and interactions of the versican C-terminal globular (G3) domain with a variety of extracellular matrix proteins, versican is a key component of well-defined ...
Day, A.J.; id_orcid 0000-0002-1415-3134 +2 more
openaire +4 more sources
Versican and Versican-matrikines in Cancer Progression, Inflammation, and Immunity
Journal of Histochemistry & Cytochemistry, 2020 Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer development, ranging from proliferative signaling, evasion of growth-suppressor pathways, regulation of cell death, promotion of neoangiogenesis, and tissue invasion and metastasis.
Athanasios, Papadas +4 more
openaire +3 more sources