Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury [PDF]
Nature Communications, 2022 Inflammation resolution failure is a pathological hallmark of spinal cord injury. Here, the authors show in rodents that chondroitin sulfate proteoglycans contribute to failed resolution by preventing immune cells at the injury core from converting to a ...
Isaac Francos-Quijorna +9 more
doaj +2 more sources
Roles of Chondroitin Sulfate Proteoglycans as Regulators of Skeletal Development [PDF]
Frontiers in Cell and Developmental Biology, 2022 The extracellular matrix (ECM) is critically important for most cellular processes including differentiation, morphogenesis, growth, survival and regeneration.
Nancy B. Schwartz +2 more
doaj +2 more sources
Olfactory ensheathing cell transplantation alters the expression of chondroitin sulfate proteoglycans and promotes axonal regeneration after spinal cord injury [PDF]
Neural Regeneration Research, 2021 Cell transplantation is a potential treatment for spinal cord injury. Olfactory ensheathing cells (OECs) play an active role in the repair of spinal cord injury as a result of the dual characteristics of astrocytes and Schwann cells.
Guo-Yu Wang +4 more
doaj +2 more sources
Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology. [PDF]
J Neurosci ResABSTRACT Chondroitin sulfate proteoglycans (CSPGs) are major components of the matrix in many tissues including the central nervous system (CNS). Interactions between extracellular CSPGs and different cell types are crucial for the development of the CNS as CSPGs are heavily involved in maintaining the pool of progenitors ...
Hosseini SM, Karimi-Abdolrezaee S.
europepmc +3 more sources
NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. [PDF]
Nat Neurosci, 2012 In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin-associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting following injury. The Nogo receptor family members NgR1 and NgR2 bind to MAIs and have been implicated in neuronal inhibition.
Dickendesher TL +13 more
europepmc +6 more sources
Chondroitin sulfate proteoglycans from salmon nasal cartilage inhibit angiogenesis [PDF]
Biochemistry and Biophysics Reports, 2017 Because cartilage lacks nerves, blood vessels, and lymphatic vessels, it is thought to contain factors that inhibit the growth and development of those tissues.
Takashi Kobayashi +3 more
doaj +2 more sources
Chondroitin sulfate proteoglycans in the nervous system: inhibitors to repair. [PDF]
Biomed Res Int, 2014 Chondroitin sulfate proteoglycans (CSPGs) are widely expressed in the normal central nervous system, serving as guidance cues during development and modulating synaptic connections in the adult. With injury or disease, an increase in CSPG expression is commonly observed close to lesioned areas. However, these CSPG deposits form a substantial barrier to
Siebert JR +2 more
europepmc +4 more sources
Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans
Neural Regeneration Research, 2017 The current dogma in neural regeneration research implies that chondroitin sulfate proteoglycans (CSPGs) inhibit plasticity and regeneration in the adult central nervous system (CNS). We argue that the role of the CSPGs can be reversed from inhibition to
Heikki Rauvala +3 more
doaj +2 more sources
Contributions of chondroitin sulfate proteoglycans to neurodevelopment, injury, and cancer. [PDF]
Curr Opin Neurobiol, 2014 Chondroitin sulfate proteoglycans (CSPGs) are a diverse family of extracellular matrix (ECM) molecules that make significant contributions to the patterning and routing of migrating neural cells and extending axons. Three distinct modes of migration mediation result from the relative abundance and positioning of expressed CSPGs, the profile of CSPG ...
Silver DJ, Silver J.
europepmc +4 more sources
Global analysis of neuronal phosphoproteome regulation by chondroitin sulfate proteoglycans. [PDF]
PLoS ONE, 2013 Chondroitin sulfate proteoglycans (CSPGs) are major components of the extracellular matrix which mediate inhibition of axonal regeneration after injury to the central nervous system (CNS).
Panpan Yu +7 more
doaj +2 more sources