Results 11 to 20 of about 16,792 (188)

Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis [PDF]

Brain, 2018
Manoj Kumar Mishra, Erin Stephenson, V Wee Yong   +2 more
exaly   +2 more sources

The Effects of Normal Aging on Regional Accumulation of Hyaluronan and Chondroitin Sulfate Proteoglycans in the Mouse Brain [PDF]

Journal of Histochemistry and Cytochemistry, 2018
William Banks, Michelle Erickson, May Reed   +2 more
exaly   +2 more sources

Increased Cerebral Serum Amyloid A2 and Parameters of Oxidation in Arylsulfatase B (N-Acetylgalactosamine-4-Sulfatase)-Null Mice

Journal of Alzheimer's Disease Reports, 2023
Background: Chondroitin sulfate and chondroitin sulfate proteoglycans have been associated with Alzheimer’s disease (AD), and the impact of modified chondroitin sulfates is being investigated in several animal and cell-based models of AD.
Sumit Bhattacharyya, Joanne K. Tobacman
doaj   +1 more source

Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles

Frontiers in Cell and Developmental Biology, 2021
Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, heparan sulfate, and keratan sulfate, except for hyaluronan that is a free polysaccharide, are covalently attached to core proteins to form proteoglycans.
Yi-Fan Huang, Shuji Mizumoto, Morihisa Fujita   +2 more
doaj   +1 more source

Identification of function-regulating antibodies targeting the receptor protein tyrosine phosphatase sigma ectodomain. [PDF]

PLoS ONE, 2017
Receptor tyrosine phosphatase sigma (RPTPσ) plays an important role in the regulation of axonal outgrowth and neural regeneration. Recent studies have identified two RPTPσ ligands, chondroitin sulfate proteoglycans (CSPGs) and heparan sulfate ...
Chia-Lun Wu, Serge Hardy, Isabelle Aubry, Melissa Landry, Allison Haggarty, Horacio Uri Saragovi, Michel L Tremblay   +6 more
doaj   +1 more source

Contributions of Chondroitin Sulfate, Keratan Sulfate and N-linked Oligosaccharides to Inhibition of Neurite Outgrowth by Aggrecan

Biology, 2020
The role of proteoglycans in the central nervous system (CNS) is a rapidly evolving field and has major implications in the field of CNS injury. Chondroitin sulfate proteoglycans (CSPGs) increase in abundance following damage to the spinal cord and ...
Thomas M. Hering, Justin A. Beller, Christopher M. Calulot, Diane M. Snow   +3 more
doaj   +1 more source

Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis

Frontiers in Genetics, 2021
Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan sulfate are covalently attached to specific core proteins to form proteoglycans, which are distributed at the cell surface as well as in the extracellular matrix ...
Shuji Mizumoto, Shuhei Yamada
doaj   +1 more source

Glycosaminoglycan linkage region of urinary bikunin as a potentially useful biomarker for β3GalT6‐deficient spondylodysplastic Ehlers–Danlos syndrome

JIMD Reports, 2022
The spondylodysplastic type of Ehlers–Danlos syndrome (spEDS) is caused by genetic defects in the B4GALT7 or B3GALT6 genes both deranging the biosynthesis of the glycosaminoglycan linkage region of chondroitin/dermatan sulfate and heparan sulfate ...
Mahnaz Nikpour, Fredrik Noborn, Jonas Nilsson, Tim Van Damme, Olivier Kaye, Delfien Syx, Fransiska Malfait, Göran Larson   +7 more
doaj   +1 more source

Biphasic role of chondroitin sulfate in cardiac differentiation of embryonic stem cells through inhibition of Wnt/β-catenin signaling. [PDF]

PLoS ONE, 2014
The glycosaminoglycan chondroitin sulfate is a critical component of proteoglycans on the cell surface and in the extracellular matrix. As such, chondroitin sulfate side chains and the sulfation balance of chondroitin play important roles in the control ...
Robert D Prinz, Catherine M Willis, Toin H van Kuppevelt, Michael Klüppel   +3 more
doaj   +1 more source

An Overview of in vivo Functions of Chondroitin Sulfate and Dermatan Sulfate Revealed by Their Deficient Mice

Frontiers in Cell and Developmental Biology, 2021
Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) are covalently attached to specific core proteins to form proteoglycans in their biosynthetic pathways.
Shuji Mizumoto, Shuhei Yamada
doaj   +1 more source